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Chemical Compound Review

elastatinal     (2S)-2-[[(S)-[(1S)-3- aminocarbonyl-1...

Synonyms: CHEMBL1172108, KST-1A5386, AC1L3MHP, LS-71756, AR-1A3610, ...
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Disease relevance of elastatinal

  • This activity was inhibited by the elastase inhibitors elastatinal and N-(methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine chloromethylketone (drugs known also to be inhibitors of poliovirus protease 2A), a caspase inhibitor zVAD(OMe), fmk, and some other protease inhibitors [1].
  • Effects of elastatinal, a protease inhibitor, on DNA repair and its cytotoxicity were investigated in normal human, xeroderma pigmentosum and Chinese hamster V79 cells [2].
  • Elastatinal, a specific inhibitor of elastases, isolated from actinomycetes (Streptomyces griseoruber), forms stable complexes with elastase from human (Ki = 6.2 X 10(-6)M) and canine granulocytes (Ki = 1.1 X 10(-6)M) [3].

High impact information on elastatinal


Biological context of elastatinal


Anatomical context of elastatinal


Associations of elastatinal with other chemical compounds


Gene context of elastatinal


  1. Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores. Belov, G.A., Lidsky, P.V., Mikitas, O.V., Egger, D., Lukyanov, K.A., Bienz, K., Agol, V.I. J. Virol. (2004) [Pubmed]
  2. Cytotoxic effects of protease inhibitors on human cells. 2. Effect of elastatinal. Yagi, T., Ishizaki, K., Takebe, H. Cancer Lett. (1980) [Pubmed]
  3. Elastases from human and canine granulocytes, II. Interaction with protease inhibitors of animal, plant, and microbial origin. Schiessler, H., Ohlsson, K., Olsson, I., Arnhold, M., Birk, Y., Fritz, H. Hoppe-Seyler's Z. Physiol. Chem. (1977) [Pubmed]
  4. Elastase in intestinal mucus enhances the cytotoxicity of Shiga toxin type 2d. Kokai-Kun, J.F., Melton-Celsa, A.R., O'Brien, A.D. J. Biol. Chem. (2000) [Pubmed]
  5. Phorbol ester-induced activation of a membrane-bound candidate pro-transforming growth factor-alpha processing enzyme. Harano, T., Mizuno, K. J. Biol. Chem. (1994) [Pubmed]
  6. Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G. Maison, C.M., Villiers, C.L., Colomb, M.G. J. Immunol. (1991) [Pubmed]
  7. A unique trypsin-like protease associated with plasma membranes of rat liver. Tanaka, K., Nakamura, T., Ichihara, A. J. Biol. Chem. (1986) [Pubmed]
  8. Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors. Molla, A., Hellen, C.U., Wimmer, E. J. Virol. (1993) [Pubmed]
  9. Elastatinal and leupeptin: effects on u.v.-induced mutation and sister-chromatid exchanges in Chinese hamster cells. Paul, P., Fujiwara, Y. Carcinogenesis (1981) [Pubmed]
  10. Increased survival of rat hepatocytes in serum-free medium by inhibition of a trypsin-like protease associated with their plasma membranes. Nakamura, T., Asami, O., Tanaka, K., Ichihara, A. Exp. Cell Res. (1984) [Pubmed]
  11. N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant. Lim, J.K., Lu, W., Hartley, O., Devico, A.L. J. Leukoc. Biol. (2006) [Pubmed]
  12. Increased expression of promatrix metalloproteinase-9 and neutrophil elastase in canine dilated cardiomyopathy. Gilbert, S.J., Wotton, P.R., Tarlton, J.F., Duance, V.C., Bailey, A.J. Cardiovasc. Res. (1997) [Pubmed]
  13. Fibrin degradation in the synovial fluid of rheumatoid arthritis patients: a model for extravascular fibrinolysis. Carmassi, F., de Negri, F., Morale, M., Song, K.Y., Chung, S.I. Semin. Thromb. Hemost. (1996) [Pubmed]
  14. Various proteinase inhibitors decrease prolactin and growth hormone release by anterior pituitary cells. Rappay, G., Makara, G.B., Bajusz, S., Nagy, I. Life Sci. (1985) [Pubmed]
  15. Elastase-type activity in human radial artery in patients with chronic renal failure. Narita, M., Aoyagi, K., Ohba, S., Tojo, S. Nephron (1986) [Pubmed]
  16. Purification, characterization and activation of fish muscle prokallikrein. Richards, G.P., Liang, Y.M., Chao, J., Chao, L. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1997) [Pubmed]
  17. Characterization of two midgut proteinases of Helicoverpa armigera and their interaction with proteinase inhibitors. Telang, M.A., Giri, A.P., Sainani, M.N., Gupta, V.S. J. Insect Physiol. (2005) [Pubmed]
  18. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Feinstein, G., Malemud, C.J., Janoff, A. Biochim. Biophys. Acta (1976) [Pubmed]
  19. Prevention of normal mouse uterine maturation by antipain and elastatinal: suppression of peroxidase activity. Katz, J., Troll, W., Genunchi, A., Levitz, M. Endocrine research communications. (1978) [Pubmed]
  20. Purification, kinetical and molecular characterizations of a serine collagenolytic protease from greenshore crag (Carcinus maenas) digestive gland. Roy, P., Colas, B., Durand, P. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1996) [Pubmed]
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