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Gene Review

Hrh1  -  histamine receptor H 1

Rattus norvegicus

Synonyms: H1R, HH1R, Histamine H1 receptor
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Analytical, diagnostic and therapeutic context of Hrh1


  1. Involvement of central cholinergic muscarinic receptors and histamine H1 receptors in hyperglycemia induced by prostaglandin F2 alpha in rats. Nonogaki, K., Iguchi, A., Zhu, L.X., Kunoh, Y., Tamagawa, T., Sakamoto, N. Neuroendocrinology (1993) [Pubmed]
  2. Capsaicin-sensitive vagal afferent fibers do not contribute to histamine H2 receptor agonist-induced gastric acid secretion in anesthetized rats. Yoneda, M., Raybould, H.E. Eur. J. Pharmacol. (1990) [Pubmed]
  3. Interference of cetirizine with the late eosinophil accumulation induced by either PAF or compound 48/80. Martins, M.A., Pasquale, C.P., e Silva, P.M., Pires, A.L., Ruffié, C., Rihoux, J.P., Cordeiro, R.S., Vargaftig, B.B. Br. J. Pharmacol. (1992) [Pubmed]
  4. Suppressive effects of histamine H1 receptor antagonist diphenhydramine on the leukocyte infiltration during endotoxin-induced uveitis. Yamashiro, K., Kiryu, J., Tsujikawa, A., Nonaka, A., Honjo, M., Tanihara, H., Nishiwaki, H., Honda, Y., Ogura, Y. Exp. Eye Res. (2001) [Pubmed]
  5. In vivo biliary excretion and in vitro cellular accumulation of thyroxine by rats or cultured rat hepatocytes treated with a novel histamine H1-receptor antagonist. Poole, A., Pritchard, D., Jones, R.B., Catto, L., Leonard, T. Arch. Toxicol. (1990) [Pubmed]
  6. Neuronal histamine modulates feeding behavior through H1-receptor in rat hypothalamus. Fukagawa, K., Sakata, T., Shiraishi, T., Yoshimatsu, H., Fujimoto, K., Ookuma, K., Wada, H. Am. J. Physiol. (1989) [Pubmed]
  7. Carcinogenesis by nonmutagenic chemicals: early response of rat liver cells induced by methapyrilene. Iype, P.T., Bucana, C.D., Kelley, S.P. Cancer Res. (1985) [Pubmed]
  8. Histamine H1 receptor binding capacities in the amygdalas of the amygdaloid kindled rat. Toyota, H., Ito, C., Yanai, K., Sato, M., Watanabe, T. J. Neurochem. (1999) [Pubmed]
  9. Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Sawynok, J., Esser, M.J., Reid, A.R. Pain (1999) [Pubmed]
  10. Histamine H1 receptor antagonists produce increases in extracellular acetylcholine in rat frontal cortex and hippocampus. Dringenberg, H.C., De Souza-Silva, M.A., Rossmüller, J., Huston, J.P., Schwarting, R.K. J. Neurochem. (1998) [Pubmed]
  11. Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation. de Paula, L., Santos, W.F., Malheiro, A., Carlos, D., Faccioli, L.H. Int. Immunopharmacol. (2006) [Pubmed]
  12. Effect of mizolastine on visceral sensory afferent sensitivity and inflammation during experimental colitis. Goldhill, J., Pichat, P., Roome, N., Angel, I., Arbilla, S. Arzneimittel-Forschung. (1998) [Pubmed]
  13. Genomic cloning of the rat histamine H1 receptor. Fujimoto, K., Horio, Y., Sugama, K., Ito, S., Liu, Y.Q., Fukui, H. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  14. In vivo electrophysiological investigations into the role of histamine in the dentate gyrus of the rat. Manahan-Vaughan, D., Reymann, K.G., Brown, R.E. Neuroscience (1998) [Pubmed]
  15. Increase of plasma renin activity after subcutaneous application of compound 48/80 in the rat. Izumi, H., Ho, S., Michelakis, A.M., Aoki, T. Eur. J. Pharmacol. (1985) [Pubmed]
  16. Effect of morphine, naloxone and histamine system on water intake in adult male rats. Eidi, M., Oryan, S., Eidi, A., Sepehrara, L. Eur. J. Pharmacol. (2003) [Pubmed]
  17. Activation of histamine H1-receptor enhances neurotrophic factor secretion from cultured astrocytes. Lipnik-Stangelj, M., Carman-Krzan, M. Inflamm. Res. (2004) [Pubmed]
  18. Histamine modulates heat stress-induced changes in blood-brain barrier permeability, cerebral blood flow, brain oedema and serotonin levels: an experimental study in conscious young rats. Sharma, H.S., Nyberg, F., Cervos-Navarro, J., Dey, P.K. Neuroscience (1992) [Pubmed]
  19. Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist. Chairungsrilerd, N., Furukawa, K., Ohta, T., Nozoe, S., Ohizumi, Y. Eur. J. Pharmacol. (1996) [Pubmed]
  20. Influence of hormonal treatment on the response of the rat isolated uterus to histamine and histamine receptor agonists. Rubio, E., Estañ, L.A., Morales-Olivas, F.J., Martinez-Mir, I. Eur. J. Pharmacol. (1992) [Pubmed]
  21. Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats. Yu, Y., Kawarai, M., Koss, M.C. Eur. J. Pharmacol. (2001) [Pubmed]
  22. Histamine receptor subtypes mediating hyperpolarization in the isolated, perfused rat mesenteric pre-arteriolar bed. Adeagbo, A.S., Oriowo, M.A. Eur. J. Pharmacol. (1998) [Pubmed]
  23. A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine. Main, I.H., Whittle, B.J. J. Physiol. (Lond.) (1976) [Pubmed]
  24. Involvement of presynaptic histamine H3 receptors in the modulation of somatostatin binding and its effects on adenylyl cyclase activity in the rat frontoparietal cortex. Puebla, L., Arilla, E. J. Neurochem. (1996) [Pubmed]
  25. Capsaicin evokes secretion of nasal fluid and depletes substance P and calcitonin gene-related peptide from the nasal mucosa in the rat. Petersson, G., Malm, L., Ekman, R., Håkanson, R. Br. J. Pharmacol. (1989) [Pubmed]
  26. Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata. Tutton, P.J., Barkla, D.H. Cell Biol. Int. Rep. (1978) [Pubmed]
  27. Effect of interleukin-1beta on the ascending and descending reflex in rat small intestine. Hahn, A., Huber, A., Neumayer, N., Allescher, H.D. Eur. J. Pharmacol. (1998) [Pubmed]
  28. Modification of oestrogen-induced uterine hyperaemia by drugs in the ovariectomized rat. Phaily, S., Senior, J. J. Reprod. Fertil. (1978) [Pubmed]
  29. Endogenous histamine reduces plasma insulin-like growth factor I via H1 receptor-mediated pathway in the rat. Liao, W., Rudling, M., Möller, C., Angelin, B. Eur. J. Pharmacol. (1999) [Pubmed]
  30. The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. Andersen, P.H. Eur. J. Pharmacol. (1989) [Pubmed]
  31. GABAB receptor-mediated inhibition of histamine H1-receptor-induced inositol phosphate formation in slices of rat cerebral cortex. Crawford, M.L., Young, J.M. J. Neurochem. (1988) [Pubmed]
  32. Guinea pig histamine H1 receptor. I. Gene cloning, characterization, and tissue expression revealed by in situ hybridization. Traiffort, E., Leurs, R., Arrang, J.M., Tardivel-Lacombe, J., Diaz, J., Schwartz, J.C., Ruat, M. J. Neurochem. (1994) [Pubmed]
  33. MDMA ('ecstasy') enhances basal acetylcholine release in brain slices of the rat striatum. Fischer, H.S., Zernig, G., Schatz, D.S., Humpel, C., Saria, A. Eur. J. Neurosci. (2000) [Pubmed]
  34. Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats. Shen, J., Niijima, A., Tanida, M., Horii, Y., Maeda, K., Nagai, K. Neurosci. Lett. (2005) [Pubmed]
  35. Quantitative determination of epinastine in plasma by high-performance liquid chromatography. Ohtani, H., Kotaki, H., Sawada, Y., Iga, T. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
  36. Molecular cloning of the guinea-pig histamine H1 receptor gene. Horio, Y., Mori, Y., Higuchi, I., Fujimoto, K., Ito, S., Fukui, H. J. Biochem. (1993) [Pubmed]
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