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Gene Review

Ads1  -  anti dsDNA antibody 1

Mus musculus

Synonyms: Ads-1
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Disease relevance of Ads1


Psychiatry related information on Ads1


High impact information on Ads1

  • Thus, B cells from NZB.H-2bm12 mice, because of previous activation in vivo, can proceed to IgG anti-dsDNA antibody production in vitro without direct T cell interaction [8].
  • We have identified a new murine V kappa family that contains five to seven members, one member of which encodes the L chain V region of an anti-dsDNA antibody produced by a BALB/c hybridoma, C8 [9].
  • The present genetic studies using (NZB X NZW)F1 X NZW backcross mice and their second through fourth generation progeny revealed that Agp-1 and Ads-1 exist in common or are closely linked on chromosome 17 of NZB mice and are related to the occurrence of renal disease [10].
  • A combined effect of 2 unlinked dominant NZB loci (Ads-1 and Ads-2) is required for the production of anti-double-stranded DNA (anti-dsDNA) antibodies in these mice [10].
  • Anti-dsDNA antibody levels, however, were reduced in the absence of Ccr2 [11].

Biological context of Ads1


Anatomical context of Ads1

  • When we examined direct T cell help for the IgG anti-dsDNA antibody response, we found that we could distinguish the actions of the two cloned T cell lines studied [8].
  • We demonstrate here that, in both lupus-prone and normal mouse strains, strong anti-dsDNA antibody responses can be induced by dendritic cells (DC) that have ingested syngeneic necrotic (DC/nec), but not apoptotic (DC/apo), cells [16].
  • These data suggest that control of anti-dsDNA antibody production may rely on elements from both the innate and adaptive arms of the immune system [17].
  • HBO(2) treatment resulted in increased survival, decreased proteinuria, alterations in lymphocyte-subset redistribution, reduced anti-dsDNA antibody titers, and amelioration of immune-complex deposition in groups A and B. Our data demonstrated that HBO(2) therapy attenuated disease severity in NZB/W F1 mice [4].
  • A murine monoclonal anti-dsDNA antibody, mAb 3E10, was selectively transported into skeletal muscle cells in vivo [18].

Associations of Ads1 with chemical compounds


Other interactions of Ads1


Analytical, diagnostic and therapeutic context of Ads1


  1. Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells. Ishida, D., Su, L., Tamura, A., Katayama, Y., Kawai, Y., Wang, S.F., Taniwaki, M., Hamazaki, Y., Hattori, M., Minato, N. Immunity (2006) [Pubmed]
  2. Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Yoh, K., Itoh, K., Enomoto, A., Hirayama, A., Yamaguchi, N., Kobayashi, M., Morito, N., Koyama, A., Yamamoto, M., Takahashi, S. Kidney Int. (2001) [Pubmed]
  3. A monoclonal anti-double stranded DNA antibody from an autoimmune MRL/Mp-lpr/lpr mouse: specificity and idiotype in serum immunoglobulins. Kubota, T., Akatsuka, T., Kanai, Y. Immunol. Lett. (1986) [Pubmed]
  4. Early hyperbaric oxygen therapy attenuates disease severity in lupus-prone autoimmune (NZB x NZW) F1 mice. Chen, S.Y., Chen, Y.C., Wang, J.K., Hsu, H.P., Ho, P.S., Chen, Y.C., Sytwu, H.K. Clin. Immunol. (2003) [Pubmed]
  5. Anti-T cell receptor antibody treatment of mice with lupus-like graft versus host disease: suppression of glomerulonephritis without reduction in anti-DNA antibody levels. Maeda, T., Nomoto, K. J. Rheumatol. (1995) [Pubmed]
  6. Modulation of SLE induction in naive mice by specific T cells with suppressor activity to pathogenic anti-DNA idiotype. Blank, M., Ben-Bassat, M., Shoenfeld, Y. Cell. Immunol. (1991) [Pubmed]
  7. Multiplex inheritance of component phenotypes in a murine model of lupus. Morel, L., Mohan, C., Yu, Y., Schiffenbauer, J., Rudofsky, U.H., Tian, N., Longmate, J.A., Wakeland, E.K. Mamm. Genome (1999) [Pubmed]
  8. Comparison of the requirements for cognate T cell help for IgG anti-double-stranded DNA antibody production in vitro: T helper-derived lymphokines replace T cell cloned lines for B cells from NZB.H-2bm12 but not B6.H-2bm12 mice. Cawley, D., Chiang, B.L., Naiki, M., Ansari, A.A., Gershwin, M.E. J. Immunol. (1993) [Pubmed]
  9. Identification of a new V kappa gene family that is highly expressed in hybridomas from an autoimmune mouse strain. Shefner, R., Mayer, R., Kaushik, A., D'Eustachio, P., Bona, C., Diamond, B. J. Immunol. (1990) [Pubmed]
  10. Naturally occurring antibody response to DNA is associated with the response to retroviral gp70 in autoimmune New Zealand mice. Shirai, T., Ohta, K., Kohno, A., Furukawa, F., Yoshida, H., Maruyama, N., Hirose, S. Arthritis Rheum. (1986) [Pubmed]
  11. Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice. de Lema, G.P., Maier, H., Franz, T.J., Escribese, M., Chilla, S., Segerer, S., Camarasa, N., Schmid, H., Banas, B., Kalaydjiev, S., Busch, D.H., Pfeffer, K., Mampaso, F., Schlöndorff, D., Luckow, B. J. Am. Soc. Nephrol. (2005) [Pubmed]
  12. The effects of anti-idiotypic antibody on antibody production and apoptosis of anti-dsDNA antibody producing cells. Lee, C.H., Suh, C.H., Lee, J., Kim, Y.T., Lee, S.K. Clinical and experimental rheumatology. (2003) [Pubmed]
  13. Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19. Taylor, D.K., Ito, E., Thorn, M., Sundar, K., Tedder, T., Spatz, L.A. Mol. Immunol. (2006) [Pubmed]
  14. Paclitaxel reduces anti-dsDNA antibody titer and BUN, prolonging survival in murine lupus. Song, Y.W., Kim, H.A., Baek, H.J., Lee, E.B., Chung, E.S., Hong, K.M. Int. J. Immunopharmacol. (1998) [Pubmed]
  15. Anti-dsDNA antibody up-regulates interleukin 6, but not cyclo-oxygenase, gene expression in glomerular mesangial cells: a marker of immune-mediated renal damage? Yu, C.L., Sun, K.H., Tsai, C.Y., Hsieh, S.C., Yu, H.S. Inflamm. Res. (2001) [Pubmed]
  16. Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains. Ma, L., Chan, K.W., Trendell-Smith, N.J., Wu, A., Tian, L., Lam, A.C., Chan, A.K., Lo, C.K., Chik, S., Ko, K.H., To, C.K., Kam, S.K., Li, X.S., Yang, C.H., Leung, S.Y., Ng, M.H., Stott, D.I., MacPherson, G.G., Huang, F.P. Eur. J. Immunol. (2005) [Pubmed]
  17. The regulation and activation potential of autoreactive B cells. Fields, M.L., Seo, S.J., Nish, S.A., Tsai, J.H., Caton, A.J., Erikson, J. Immunol. Res. (2003) [Pubmed]
  18. Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb. Weisbart, R.H., Yang, F., Chan, G., Wakelin, R., Ferreri, K., Zack, D.J., Harrison, B., Leinwand, L.A., Cole, G.M. Mol. Immunol. (2003) [Pubmed]
  19. Persistence of partially functional double-stranded (ds) DNA binding B cells in mice transgenic for the IgM heavy chain of an anti-dsDNA antibody. Chu, Y.P., Taylor, D., Yan, H.G., Diamond, B., Spatz, L. Int. Immunol. (2002) [Pubmed]
  20. Effects of prostaglandin E1 on the production of IgM and IgG class anti-dsDNA antibodies in NZB/W F1 mice. Yoshikawa, T., Suzuki, H., Sugiyama, E., Tunru, I.S., Ikemoto, M., Hori, T., Matsui, S., Yamashita, N., Kobayashi, M. J. Rheumatol. (1993) [Pubmed]
  21. Anti-double strand (ds) DNA antibody formation by NZB/W (F1) spleen cells in a microculture system detected by solid phase radioimmunoassay. Okudaira, H., Terada, E., Ogita, T., Aotsuka, S., Yokohari, R. J. Immunol. Methods (1981) [Pubmed]
  22. Interleukin-6 receptor blockage ameliorates murine lupus nephritis. Kiberd, B.A. J. Am. Soc. Nephrol. (1993) [Pubmed]
  23. Novel structural features of autoantibodies in murine lupus: a possible superantigen binding site? Zack, D.J., Wong, A.L., Weisbart, R.H. Immunol. Cell Biol. (1994) [Pubmed]
  24. Chemical induction of HO-1 suppresses lupus nephritis by reducing local iNOS expression and synthesis of anti-dsDNA antibody. Takeda, Y., Takeno, M., Iwasaki, M., Kobayashi, H., Kirino, Y., Ueda, A., Nagahama, K., Aoki, I., Ishigatsubo, Y. Clin. Exp. Immunol. (2004) [Pubmed]
  25. Chronic therapy with recombinant tumor necrosis factor-alpha in autoimmune NZB/NZW F1 mice. Gordon, C., Ranges, G.E., Greenspan, J.S., Wofsy, D. Clin. Immunol. Immunopathol. (1989) [Pubmed]
  26. Idiotypic vaccination with a murine anti-dsDNA antibody: phase I study in patients with nonactive systemic lupus erythematosus with nephritis. Spertini, F., Leimgruber, A., Morel, B., Khazaeli, M.B., Yamamoto, K., Dayer, J.M., Weisbart, R.H., Lee, M.L. J. Rheumatol. (1999) [Pubmed]
  27. Reversal of established nephropathy in New Zealand B/W F1 mice by 15-deoxyspergualin. Okubo, M., Umetani, N., Inoue, K., Kamata, K., Shimoda, Y., Uchiyama, T., Aoyagi, T. Nephron (1991) [Pubmed]
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