Gene Review:
Chrm4 - cholinergic receptor, muscarinic 4
Mus musculus
Synonyms:
Chrm-4, M4, Mm4 mAChR, Muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor 4
- Interactions of agonists with M2 and M4 muscarinic receptor subtypes mediating cyclic AMP inhibition. McKinney, M., Miller, J.H., Gibson, V.A., Nickelson, L., Aksoy, S. Mol. Pharmacol. (1991)
- M2 muscarinic receptors in pontine reticular formation of C57BL/6J mouse contribute to rapid eye movement sleep generation. Coleman, C.G., Lydic, R., Baghdoyan, H.A. Neuroscience (2004)
- RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Ding, J., Guzman, J.N., Tkatch, T., Chen, S., Goldberg, J.A., Ebert, P.J., Levitt, P., Wilson, C.J., Hamm, H.E., Surmeier, D.J. Nat. Neurosci. (2006)
- A sequence in the main cytoplasmic loop of the alpha subunit is required for assembly of mouse muscle nicotinic acetylcholine receptor. Yu, X.M., Hall, Z.W. Neuron (1994)
- Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors. Bouzat, C., Bren, N., Sine, S.M. Neuron (1994)
- Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Tzavara, E.T., Bymaster, F.P., Felder, C.C., Wade, M., Gomeza, J., Wess, J., McKinzie, D.L., Nomikos, G.G. Mol. Psychiatry (2003)
- Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics. Bouzat, C., Barrantes, F., Sine, S. J. Gen. Physiol. (2000)
- Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice. Oki, T., Takagi, Y., Inagaki, S., Taketo, M.M., Manabe, T., Matsui, M., Yamada, S. Brain Res. Mol. Brain Res. (2005)
- M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. Tzavara, E.T., Bymaster, F.P., Davis, R.J., Wade, M.R., Perry, K.W., Wess, J., McKinzie, D.L., Felder, C., Nomikos, G.G. FASEB J. (2004)
- Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. Nashmi, R., Dickinson, M.E., McKinney, S., Jareb, M., Labarca, C., Fraser, S.E., Lester, H.A. J. Neurosci. (2003)
- Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum. Takeuchi, T., Fujinami, K., Goto, H., Fujita, A., Taketo, M.M., Manabe, T., Matsui, M., Hata, F. J. Neurophysiol. (2005)
- Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice. Zhang, H.M., Chen, S.R., Matsui, M., Gautam, D., Wess, J., Pan, H.L. Mol. Pharmacol. (2006)
- Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. Husain, S.S., Forman, S.A., Kloczewiak, M.A., Addona, G.H., Olsen, R.W., Pratt, M.B., Cohen, J.B., Miller, K.W. J. Med. Chem. (1999)
- Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors. Chernyavsky, A.I., Arredondo, J., Wess, J., Karlsson, E., Grando, S.A. J. Cell Biol. (2004)
- Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Bymaster, F.P., McKinzie, D.L., Felder, C.C., Wess, J. Neurochem. Res. (2003)
- Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry. Leite, J.F., Blanton, M.P., Shahgholi, M., Dougherty, D.A., Lester, H.A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice. Gomeza, J., Zhang, L., Kostenis, E., Felder, C.C., Bymaster, F.P., Brodkin, J., Shannon, H., Xia, B., Duttaroy, A., Deng, C.X., Wess, J. Life Sci. (2001)
- Molecular analysis of the regulation of muscarinic receptor expression and function. Nadler, L.S., Rosoff, M.L., Hamilton, S.E., Kalaydjian, A.E., McKinnon, L.A., Nathanson, N.M. Life Sci. (1999)
- Midkine gene and the m4 muscarinic acid receptor gene are linked on mouse chromosome 2. Kha, H., Li, Y.S., Deuel, T.F. Genomics (1996)
- Postsynaptic muscarinic M1 receptors activate prefrontal cortical EEG of C57BL/6J mouse. Douglas, C.L., Baghdoyan, H.A., Lydic, R. J. Neurophysiol. (2002)
- A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics. Salamone, F.N., Zhou, M., Auerbach, A. J. Physiol. (Lond.) (1999)