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Gene Review

Cma1  -  chymase 1, mast cell

Mus musculus

Synonyms: Alpha-chymase, Chymase, MMCP-5, Mast cell chymase 1, Mast cell protease 5, ...
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Disease relevance of Cma1


High impact information on Cma1


Chemical compound and disease context of Cma1


Biological context of Cma1


Anatomical context of Cma1


Associations of Cma1 with chemical compounds


Enzymatic interactions of Cma1


Regulatory relationships of Cma1


Other interactions of Cma1


Analytical, diagnostic and therapeutic context of Cma1


  1. Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils. Terakawa, M., Tomimori, Y., Goto, M., Fukuda, Y. Eur. J. Pharmacol. (2006) [Pubmed]
  2. Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases. Huang, R.Y., Blom, T., Hellman, L. Eur. J. Immunol. (1991) [Pubmed]
  3. Translation and granule localization of mouse mast cell protease-5. Immunodetection with specific antipeptide Ig. McNeil, H.P., Frenkel, D.P., Austen, K.F., Friend, D.S., Stevens, R.L. J. Immunol. (1992) [Pubmed]
  4. Isoform-selective upregulation of mast cell chymase in the development of skin fibrosis in scleroderma model mice. Kakizoe, E., Shiota, N., Tanabe, Y., Shimoura, K., Kobayashi, Y., Okunishi, H. J. Invest. Dermatol. (2001) [Pubmed]
  5. Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis. Kitaura-Inenaga, K., Hara, M., Higuchi, K., Yamamoto, K., Yamaki, A., Ono, K., Nakano, A., Kinoshita, M., Sasayama, S., Matsumori, A. Circ. J. (2003) [Pubmed]
  6. The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. Tchougounova, E., Pejler, G., Abrink, M. J. Exp. Med. (2003) [Pubmed]
  7. Evidence for a role of mast cells in the evolution to congestive heart failure. Hara, M., Ono, K., Hwang, M.W., Iwasaki, A., Okada, M., Nakatani, K., Sasayama, S., Matsumori, A. J. Exp. Med. (2002) [Pubmed]
  8. Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase. Fang, K.C., Raymond, W.W., Lazarus, S.C., Caughey, G.H. J. Clin. Invest. (1996) [Pubmed]
  9. Deficient transcription of mouse mast cell protease 4 gene in mutant mice of mi/mi genotype. Jippo, T., Lee, Y.M., Katsu, Y., Tsujino, K., Morii, E., Kim, D.K., Kim, H.M., Kitamura, Y. Blood (1999) [Pubmed]
  10. Mast cell chymase. A potent secretagogue for airway gland serous cells. Sommerhoff, C.P., Caughey, G.H., Finkbeiner, W.E., Lazarus, S.C., Basbaum, C.B., Nadel, J.A. J. Immunol. (1989) [Pubmed]
  11. Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells. McNeil, H.P., Austen, K.F., Somerville, L.L., Gurish, M.F., Stevens, R.L. J. Biol. Chem. (1991) [Pubmed]
  12. Chymase participates in chronic dermatitis by inducing eosinophil infiltration. Tomimori, Y., Muto, T., Fukami, H., Saito, K., Horikawa, C., Tsuruoka, N., Saito, M., Sugiura, N., Yamashiro, K., Sumida, M., Kakutani, S., Fukuda, Y. Lab. Invest. (2002) [Pubmed]
  13. Mast cell-mediated inhibition of reverse cholesterol transport. Lee, M., Lindstedt, L.K., Kovanen, P.T. Arterioscler. Thromb. (1992) [Pubmed]
  14. Abnormal expression of mouse mast cell protease 5 gene in cultured mast cells derived from mutant mi/mi mice. Morii, E., Jippo, T., Tsujimura, T., Hashimoto, K., Kim, D.K., Lee, Y.M., Ogihara, H., Tsujino, K., Kim, H.M., Kitamura, Y. Blood (1997) [Pubmed]
  15. A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. Tchougounova, E., Lundequist, A., Fajardo, I., Winberg, J.O., Abrink, M., Pejler, G. J. Biol. Chem. (2005) [Pubmed]
  16. Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway. Terakawa, M., Tomimori, Y., Goto, M., Hayashi, Y., Oikawa, S., Fukuda, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  17. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14. Gurish, M.F., Nadeau, J.H., Johnson, K.R., McNeil, H.P., Grattan, K.M., Austen, K.F., Stevens, R.L. J. Biol. Chem. (1993) [Pubmed]
  18. Purification of mast cell proteases from murine skin. Algermissen, B., Laubscher, J.C., Bauer, F., Henz, B.M. Exp. Dermatol. (1999) [Pubmed]
  19. Altered processing of fibronectin in mice lacking heparin. a role for heparin-dependent mast cell chymase in fibronectin degradation. Tchougounova, E., Forsberg, E., Angelborg, G., Kjéllen, L., Pejler, G. J. Biol. Chem. (2001) [Pubmed]
  20. Depletion of pre beta 1LpA1 and LpA4 particles by mast cell chymase reduces cholesterol efflux from macrophage foam cells induced by plasma. Lee, M., von Eckardstein, A., Lindstedt, L., Assmann, G., Kovanen, P.T. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  21. Role of mast cell chymase in allergen-induced biphasic skin reaction. Tomimori, Y., Tsuruoka, N., Fukami, H., Saito, K., Horikawa, C., Saito, M., Muto, T., Sugiura, N., Yamashiro, K., Sumida, M., Kakutani, S., Fukuda, Y. Biochem. Pharmacol. (2002) [Pubmed]
  22. Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux. Lee, M., Calabresi, L., Chiesa, G., Franceschini, G., Kovanen, P.T. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  23. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. Gurish, M.F., Ghildyal, N., McNeil, H.P., Austen, K.F., Gillis, S., Stevens, R.L. J. Exp. Med. (1992) [Pubmed]
  24. Characterization of unmyelinated axons uniting epidermal and dermal immune cells in primate and murine skin. Egan, C.L., Viglione-Schneck, M.J., Walsh, L.J., Green, B., Trojanowski, J.Q., Whitaker-Menezes, D., Murphy, G.F. J. Cutan. Pathol. (1998) [Pubmed]
  25. Involvement of mast cell chymase in bleomycin-induced pulmonary fibrosis in mice. Tomimori, Y., Muto, T., Saito, K., Tanaka, T., Maruoka, H., Sumida, M., Fukami, H., Fukuda, Y. Eur. J. Pharmacol. (2003) [Pubmed]
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