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Gene Review

Cpa1  -  carboxypeptidase A1, pancreatic

Mus musculus

Synonyms: 0910001L12Rik, Carboxypeptidase A1, Cpa
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Disease relevance of Cpa1

  • The Cpa1 and Cpa2 cyclophilin A proteins play a shared role in cell growth, mating, virulence and CsA toxicity [1].
  • In addition, endogenously activated CPA95 could effectively sensitize cells to MTX-Phe in culture, decreasing the IC50 of MTX-Phe from 25- to 250-fold in squamous cell carcinoma cells expressing active CPA as compared with the parental lines [2].

High impact information on Cpa1


Biological context of Cpa1

  • In a previous report, the ob mutation was mapped to a position 5 cM distal to Met on murine Chromosome (Chr) 6 in tight linkage to Cpa [7].
  • Toward an enzyme/prodrug strategy for cancer gene therapy: endogenous activation of carboxypeptidase A mutants by the PACE/Furin family of propeptidases [2].
  • The complete heavy-chain variable region (VH) amino acid sequence was obtained by automated Edman degradation of the intact chain and fragments due to CNBr cleavage, trypsin digestion, mild acid hydrolysis, and carboxypeptidase A digestion of a CNBr fragment [8].
  • The findings suggest that both FctA and Cpa are required for pilus formation, but importantly, an intact pilus is not essential for Cpa-mediated virulence [9].
  • Methoxypoly(ethylene glycol)-conjugated carboxypeptidase A for solid tumor targeting: part II: pharmacokinetics and biodistribution in normal and tumor-bearing rodents [10].

Anatomical context of Cpa1


Associations of Cpa1 with chemical compounds


Other interactions of Cpa1


Analytical, diagnostic and therapeutic context of Cpa1


  1. Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. Wang, P., Cardenas, M.E., Cox, G.M., Perfect, J.R., Heitman, J. EMBO Rep. (2001) [Pubmed]
  2. Toward an enzyme/prodrug strategy for cancer gene therapy: endogenous activation of carboxypeptidase A mutants by the PACE/Furin family of propeptidases. Hamstra, D.A., Rehemtulla, A. Hum. Gene Ther. (1999) [Pubmed]
  3. Heparin is essential for the storage of specific granule proteases in mast cells. Humphries, D.E., Wong, G.W., Friend, D.S., Gurish, M.F., Qiu, W.T., Huang, C., Sharpe, A.H., Stevens, R.L. Nature (1999) [Pubmed]
  4. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lützelschwab, C., Pejler, G., Aveskogh, M., Hellman, L. J. Exp. Med. (1997) [Pubmed]
  5. Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7. Bućan, M., Yang-Feng, T., Colberg-Poley, A.M., Wolgemuth, D.J., Guenet, J.L., Francke, U., Lehrach, H. EMBO J. (1986) [Pubmed]
  6. Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan. Roques, B.P., Lucas-Soroca, E., Chaillet, P., Costentin, J., Fournié-Zaluski, M.C. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  7. Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation. Bahary, N., Siegel, D.A., Walsh, J., Zhang, Y., Leopold, L., Leibel, R., Proenca, R., Friedman, J.M. Mamm. Genome (1993) [Pubmed]
  8. Complete amino acid sequence of the heavy-chain variable region from an A/J mouse antigen-nonbinding monoclonal antibody bearing the predominant arsonate idiotype. Smith, J.A., Margolies, M.N. Biochemistry (1984) [Pubmed]
  9. Role of streptococcal T antigens in superficial skin infection. Lizano, S., Luo, F., Bessen, D.E. J. Bacteriol. (2007) [Pubmed]
  10. Methoxypoly(ethylene glycol)-conjugated carboxypeptidase A for solid tumor targeting: part II: pharmacokinetics and biodistribution in normal and tumor-bearing rodents. Ton, G.N., Weichert, J.P., Longino, M.A., Fine, J.P., Kwon, G.S. Journal of controlled release : official journal of the Controlled Release Society. (2005) [Pubmed]
  11. Assignment of the gene for carboxypeptidase A to human chromosome 7q22----qter and to mouse chromosome 6. Honey, N.K., Sakaguchi, A.Y., Lalley, P.A., Quinto, C., Rutter, W.J., Naylor, S.L. Hum. Genet. (1986) [Pubmed]
  12. Identification and characterization of undifferentiated mast cells in mouse bone marrow. Jamur, M.C., Grodzki, A.C., Berenstein, E.H., Hamawy, M.M., Siraganian, R.P., Oliver, C. Blood (2005) [Pubmed]
  13. Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker. Serafin, W.E., Dayton, E.T., Gravallese, P.M., Austen, K.F., Stevens, R.L. J. Immunol. (1987) [Pubmed]
  14. Immortalization of murine connective tissue-type mast cells at multiple stages of their differentiation by coculture of splenocytes with fibroblasts that produce Kirsten sarcoma virus. Reynolds, D.S., Serafin, W.E., Faller, D.V., Wall, D.A., Abbas, A.K., Dvorak, A.M., Austen, K.F., Stevens, R.L. J. Biol. Chem. (1988) [Pubmed]
  15. Inhibition of pancreatic carboxypeptidase A: A possible mechanism of interaction between penicillic acid and ochratoxin A. Parker, R.W., Phillips, T.D., Kubena, L.F., Russell, L.H., Heidelbaugh, N.D. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1982) [Pubmed]
  16. Structural characteristics of interferons from mouse Ehrlich ascites tumor cells. Cabrer, B., Taira, H., Broeze, R.J., Kempe, T.D., Williams, K., Slattery, E., Konigsberg, W.H., Lengyel, P. J. Biol. Chem. (1979) [Pubmed]
  17. Mapping the midkine family of developmentally regulated signaling molecules. Peichel, C.L., Scherer, S.W., Tsui, L.C., Beier, D.R., Vogt, T.F. Mamm. Genome (1993) [Pubmed]
  18. A role for cathepsin E in the processing of mast-cell carboxypeptidase A. Henningsson, F., Yamamoto, K., Saftig, P., Reinheckel, T., Peters, C., Knight, S.D., Pejler, G. J. Cell. Sci. (2005) [Pubmed]
  19. Altered processing of fibronectin in mice lacking heparin. a role for heparin-dependent mast cell chymase in fibronectin degradation. Tchougounova, E., Forsberg, E., Angelborg, G., Kjéllen, L., Pejler, G. J. Biol. Chem. (2001) [Pubmed]
  20. Cathepsin A/protective protein: an unusual lysosomal multifunctional protein. Hiraiwa, M. Cell. Mol. Life Sci. (1999) [Pubmed]
  21. Cytokine mRNA are preferentially increased relative to secretory granule protein mRNA in mouse bone marrow-derived mast cells that have undergone IgE-mediated activation and degranulation. Gurish, M.F., Ghildyal, N., Arm, J., Austen, K.F., Avraham, S., Reynolds, D., Stevens, R.L. J. Immunol. (1991) [Pubmed]
  22. Antinociceptive effect of some carboxypeptidase A inhibitors in comparison with D-phenylalanine. Giusti, P., Carrara, M., Cima, L., Borin, G. Eur. J. Pharmacol. (1985) [Pubmed]
  23. Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. Henningsson, F., Ledin, J., Lunderius, C., Wilén, M., Hellman, L., Pejler, G. Biol. Chem. (2002) [Pubmed]
  24. Partial purification and characterization of neutrophic substance affecting tetrodotoxin sensitivity of organ-cultured mouse muscle. Kuromi, H., Gonoi, T., Hasegawa, S. Brain Res. (1979) [Pubmed]
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