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Gene Review

Cyp24a1  -  cytochrome P450, family 24, subfamily a,...

Mus musculus

Synonyms: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 24-OHase, 25-hydroxyvitamin D-24-hydroxylase, CP24, Cyp-24, ...
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Disease relevance of Cyp24a1

  • A study was conducted to evaluate the immunogenicity of the Brucella melitensis ribosome recycling factor (RRF)-homologous protein (CP24) [1].
  • The CP24 gene was cloned, expressed in Escherichia coli and purified [1].

High impact information on Cyp24a1


Biological context of Cyp24a1

  • This phenotype was rescued by crossing the 24-OHase mutant mice to mice harboring a targeted mutation in the vitamin D receptor gene, confirming that the elevated 1,25(OH)2D levels, acting through the vitamin D receptor, were responsible for the observed accumulation of osteoid [5].
  • Our results confirm the physiological importance of the 24-OHase enzyme for maintaining vitamin D homeostasis, and they reveal that 24,25-dihydroxyvitamin D is a dispensable metabolite during bone development [5].
  • Surprisingly, complete absence of 24-OHase activity during development leads to impaired intramembranous bone mineralization [5].
  • The addition of dibutyryl cAMP (dbc AMP) to activin A-treated MEL cells dose-dependently attenuated 1,25(OH)2D3-mediated induction of 24-OHase activity, finally to a level comparable to that of the untreated cells at the final concentration of 100 nM dbcAMP, while dbcAMP itself by 100 nM did not affect MEL cell differentiation by 24 h [6].
  • A cDNA encoding a 25-hydroxyvitamin D-3 24-hydroxylase, Cyp-24, has been isolated from mouse kidney cDNA library by hybridization screening [7].

Anatomical context of Cyp24a1


Associations of Cyp24a1 with chemical compounds


Regulatory relationships of Cyp24a1

  • The present study was undertaken to evaluate the response of Hyp mice to regulators known to inhibit renal 25-hydroxyvitamin D3-1-hydroxylase (1-hydroxylase) and stimulate renal 25-hydroxyvitamin D-24-hydroxylase (24-hydroxylase) [12].

Other interactions of Cyp24a1

  • Both OCT and 1,25(OH)2D3 at 24 pmol/g body wt (i.p.) induced a single, 3.4-kb mRNA encoding vitamin D 24-hydroxylase (24-OHase), the cytochrome P450 enzyme responsible for 1,25(OH)2D3 degradation, in kidney and duodenum [13].

Analytical, diagnostic and therapeutic context of Cyp24a1


  1. Immunogenicity of the Brucella melitensis recombinant ribosome recycling factor-homologous protein and its cDNA. Cassataro, J., Velikovsky, C.A., Giambartolomei, G.H., Estein, S., Bruno, L., Cloeckaert, A., Bowden, R.A., Spitz, M., Fossati, C.A. Vaccine (2002) [Pubmed]
  2. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. Shimada, T., Hasegawa, H., Yamazaki, Y., Muto, T., Hino, R., Takeuchi, Y., Fujita, T., Nakahara, K., Fukumoto, S., Yamashita, T. J. Bone Miner. Res. (2004) [Pubmed]
  3. Plasma 24,25-dihydroxyvitamin D3 concentrations in X-linked hypophosphatemic mice: studies using mass fragmentographic and radioreceptor assays. Cunningham, J., Coldwell, R.D., Jones, G., Tenenhouse, H.S., Trafford, D.J., Makin, H.L. J. Bone Miner. Res. (1990) [Pubmed]
  4. Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse. Masuda, S., Byford, V., Arabian, A., Sakai, Y., Demay, M.B., St-Arnaud, R., Jones, G. Endocrinology (2005) [Pubmed]
  5. Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D. St-Arnaud, R., Arabian, A., Travers, R., Barletta, F., Raval-Pandya, M., Chapin, K., Depovere, J., Mathieu, C., Christakos, S., Demay, M.B., Glorieux, F.H. Endocrinology (2000) [Pubmed]
  6. Modulation by cAMP of 1alpha,25-dihydroxyvitamin D3 sensitivity of murine erythroleukemia cells. Waki, M., Inaba, M., Hiura, Y., Nagasaki, T., Imanishi, Y., Ishimura, E., Otani, S., Nishizawa, Y. Arch. Biochem. Biophys. (2001) [Pubmed]
  7. Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3. Itoh, S., Yoshimura, T., Iemura, O., Yamada, E., Tsujikawa, K., Kohama, Y., Mimura, T. Biochim. Biophys. Acta (1995) [Pubmed]
  8. Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3. Akeno, N., Saikatsu, S., Kawane, T., Horiuchi, N. Endocrinology (1997) [Pubmed]
  9. Effect of 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3 on the expression of vitamin-D-responsive genes in vitamin-D-deficient mice. Yoshimura, T., Itoh, S., Tsujikawa, K., Yamada, E., Ishii, T., Iemura, O., Kameda, Y., Mimura, T., Kohama, Y. Pharmacology (1998) [Pubmed]
  10. Inhibition of steroidogenic cytochrome P-450 enzymes in rat testis by ketoconazole and related imidazole anti-fungal drugs. Kan, P.B., Hirst, M.A., Feldman, D. J. Steroid Biochem. (1985) [Pubmed]
  11. Analogs of 1alpha,25-dihydroxyvitamin D(3) as novel inhibitors of renin biosynthesis. Qiao, G., Kong, J., Uskokovic, M., Li, Y.C. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
  12. Effect of the X-linked Hyp mutation and vitamin D status on induction of renal 25-hydroxyvitamin D3-24-hydroxylase. Tenenhouse, H.S., Jones, G. Endocrinology (1987) [Pubmed]
  13. Induction of vitamin D 24-hydroxylase messenger RNA and activity by 22-oxacalcitriol in mouse kidney and duodenum. Possible role in decrease of plasma 1 alpha,25-dihydroxyvitamin D3. Akeno, N., Saikatsu, S., Kimura, S., Horiuchi, N. Biochem. Pharmacol. (1994) [Pubmed]
  14. Hydroxylases involved in vitamin D metabolism are differentially expressed in murine embryonic kidney: application of whole mount in situ hybridization. Yamagata, M., Kimoto, A., Michigami, T., Nakayama, M., Ozono, K. Endocrinology (2001) [Pubmed]
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