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Gene Review

S100g  -  S100 calcium binding protein G

Mus musculus

Synonyms: AU042539, CABP, CABP1, CaBP-D9K, Cabp9k, ...
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Disease relevance of S100g


High impact information on S100g


Biological context of S100g


Anatomical context of S100g


Associations of S100g with chemical compounds


Regulatory relationships of S100g


Other interactions of S100g

  • The skeletal response to pregnancy was comparable in wt and VDR-/- mice; duodenal CaBP-D9k concentrations increased during pregnancy in VDR-/- as in wt mice, but remained 40% lower than in wt mice [1].
  • The developmental appearance of vitamin D-dependent calcium-binding protein (calbindin-D9k) and alkaline phosphatase was studied in oc mutant and normal mice from birth to weaning, as were serum concentrations of 25-hydroxyvitamin D3 (25OHD3), 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], calcium, and phosphorus [17].
  • ST-630 was more effective than 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3] with respect to the induction of Cyp24 and calbindin-D9k mRNAs in the kidney and in the small intestine [18].

Analytical, diagnostic and therapeutic context of S100g


  1. Pregnancy in mice lacking the vitamin D receptor: normal maternal skeletal response, but fetal hypomineralization rescued by maternal calcium supplementation. Rummens, K., van Cromphaut, S.J., Carmeliet, G., van Herck, E., van Bree, R., Stockmans, I., Bouillon, R., Verhaeghe, J. Pediatr. Res. (2003) [Pubmed]
  2. Estradiol-dependent uterine leiomyomas in transgenic mice. Romagnolo, B., Molina, T., Leroy, G., Blin, C., Porteux, A., Thomasset, M., Vandewalle, A., Kahn, A., Perret, C. J. Clin. Invest. (1996) [Pubmed]
  3. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. Safadi, F.F., Thornton, P., Magiera, H., Hollis, B.W., Gentile, M., Haddad, J.G., Liebhaber, S.A., Cooke, N.E. J. Clin. Invest. (1999) [Pubmed]
  4. Ontogeny of calbindin-D28K and calbindin-D9K in the mouse kidney, duodenum, cerebellum and placenta. Shamley, D.R., Opperman, L.A., Buffenstein, R., Ross, F.P. Development (1992) [Pubmed]
  5. Intestinal expression of the calbindin-D9K gene in transgenic mice. Requirement for a Cdx2-binding site in a distal activator region. Colnot, S., Romagnolo, B., Lambert, M., Cluzeaud, F., Porteu, A., Vandewalle, A., Thomasset, M., Kahn, A., Perret, C. J. Biol. Chem. (1998) [Pubmed]
  6. Novel progestogenic activity of environmental endocrine disruptors in the upregulation of calbindin-D9k in an immature mouse model. Jung, Y.W., Hong, E.J., Choi, K.C., Jeung, E.B. Toxicol. Sci. (2005) [Pubmed]
  7. Amino acid sequence analysis of two mouse calbindin-D9k isoforms by tandem mass spectrometry. Protein modification by internal insertion of a single amino acid. Hunt, D.F., Yates, J.R., Shabanowitz, J., Bruns, M.E., Bruns, D.E. J. Biol. Chem. (1989) [Pubmed]
  8. Differential regulation by 1,25-dihydroxyvitamin D3 of calbindin-D9k and calbindin-D28k gene expression in mouse kidney. Li, H., Christakos, S. Endocrinology (1991) [Pubmed]
  9. Expression of calcium binding protein D-9k messenger RNA in the mouse uterine endometrium during implantation. Tatsumi, K., Higuchi, T., Fujiwara, H., Nakayama, T., Itoh, K., Mori, T., Fujii, S., Fujita, J. Mol. Hum. Reprod. (1999) [Pubmed]
  10. Transcriptional regulation of the mouse calbindin-D9k gene by the ovarian sex hormone. Lee, K.Y., Oh, G.T., Kang, J.H., Shin, S.M., Heo, B.E., Yun, Y.W., Paik, S.G., Krisinger, J., Leung, P.C., Jeung, E.B. Mol. Cells (2003) [Pubmed]
  11. Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection. van Abel, M., Hoenderop, J.G., van der Kemp, A.W., van Leeuwen, J.P., Bindels, R.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  12. Endometrial expression of calbindin (CaBP)-d28k but not CaBP-d9k in primates implies evolutionary changes and functional redundancy of calbindins at implantation. Luu, K.C., Nie, G.Y., Hampton, A., Fu, G.Q., Liu, Y.X., Salamonsen, L.A. Reproduction (2004) [Pubmed]
  13. Molecular cloning and chromosomal assignment of human calbindin-D9k. Howard, A., Legon, S., Spurr, N.K., Walters, J.R. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  14. Differential transcriptional and translational regulations of calbindin-D9k by steroid hormones and their receptors in the uterus of immature mice. An, B.S., Choi, K.C., Hong, E.J., Jung, Y.W., Manabe, N., Jeung, E.B. J. Reprod. Dev. (2004) [Pubmed]
  15. Thyroid hormone receptor does not heterodimerize with the vitamin D receptor but represses vitamin D receptor-mediated transactivation. Raval-Pandya, M., Freedman, L.P., Li, H., Christakos, S. Mol. Endocrinol. (1998) [Pubmed]
  16. Vitamin D receptor is required for dietary calcium-induced repression of calbindin-D9k expression in mice. Bolt, M.J., Cao, L.P., Kong, J., Sitrin, M.D., Li, Y.C. J. Nutr. Biochem. (2005) [Pubmed]
  17. Elevated levels of vitamin D-dependent calcium-binding protein (calbindin-D9k) in the osteosclerotic (oc) mouse. Seifert, M.F., Gray, R.W., Bruns, M.E. Endocrinology (1988) [Pubmed]
  18. Effect of 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3 on the expression of vitamin-D-responsive genes in vitamin-D-deficient mice. Yoshimura, T., Itoh, S., Tsujikawa, K., Yamada, E., Ishii, T., Iemura, O., Kameda, Y., Mimura, T., Kohama, Y. Pharmacology (1998) [Pubmed]
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