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Gene Review

Cyp27b1  -  cytochrome P450, family 27, subfamily b,...

Mus musculus

Synonyms: 1alpha(OH)ase, 25(OH)D 1alpha-hydroxylase, 25-OHD-1 alpha-hydroxylase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, ...
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Disease relevance of Cyp27b1


High impact information on Cyp27b1


Chemical compound and disease context of Cyp27b1


Biological context of Cyp27b1


Anatomical context of Cyp27b1


Associations of Cyp27b1 with chemical compounds


Regulatory relationships of Cyp27b1


Other interactions of Cyp27b1


  1. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Xue, Y., Karaplis, A.C., Hendy, G.N., Goltzman, D., Miao, D. Hum. Mol. Genet. (2005) [Pubmed]
  2. Evidence for abnormal translational regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in the hyp-mouse. Yuan, B., Xing, Y., Horst, R.L., Drezner, M.K. Endocrinology (2004) [Pubmed]
  3. Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection. van Abel, M., Hoenderop, J.G., van der Kemp, A.W., van Leeuwen, J.P., Bindels, R.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  4. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 alpha-hydroxylase expressed in Escherichia coli. Sakaki, T., Sawada, N., Takeyama, K., Kato, S., Inouye, K. Eur. J. Biochem. (1999) [Pubmed]
  5. The Vitamin D endocrine system of the gut--its possible role in colorectal cancer prevention. Cross, H.S., Bises, G., Lechner, D., Manhardt, T., Kállay, E. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
  6. Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets. Kitanaka, S., Takeyama, K., Murayama, A., Sato, T., Okumura, K., Nogami, M., Hasegawa, Y., Niimi, H., Yanagisawa, J., Tanaka, T., Kato, S. N. Engl. J. Med. (1998) [Pubmed]
  7. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Takeyama, K., Kitanaka, S., Sato, T., Kobori, M., Yanagisawa, J., Kato, S. Science (1997) [Pubmed]
  8. Abnormal regulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the X-linked hypophosphatemic mouse. Lobaugh, B., Drezner, M.K. J. Clin. Invest. (1983) [Pubmed]
  9. Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. Fujiki, R., Kim, M.S., Sasaki, Y., Yoshimura, K., Kitagawa, H., Kato, S. EMBO J. (2005) [Pubmed]
  10. Hypercalcemia produced by parathyroid hormone suppresses experimental autoimmune encephalomyelitis in female but not male mice. Meehan, T.F., Vanhooke, J., Prahl, J., Deluca, H.F. Arch. Biochem. Biophys. (2005) [Pubmed]
  11. Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. Murayama, A., Kim, M.S., Yanagisawa, J., Takeyama, K., Kato, S. EMBO J. (2004) [Pubmed]
  12. Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. Hoenderop, J.G., Dardenne, O., Van Abel, M., Van Der Kemp, A.W., Van Os, C.H., St -Arnaud, R., Bindels, R.J. FASEB J. (2002) [Pubmed]
  13. Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1 alpha-hydroxylase knockout mice. Hoenderop, J.G., Chon, H., Gkika, D., Bluyssen, H.A., Holstege, F.C., St-Arnaud, R., Braam, B., Bindels, R.J. Kidney Int. (2004) [Pubmed]
  14. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. Bland, R., Markovic, D., Hills, C.E., Hughes, S.V., Chan, S.L., Squires, P.E., Hewison, M. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
  15. The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice. Kovacs, C.S., Woodland, M.L., Fudge, N.J., Friel, J.K. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  16. Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion. Huang, D.C., Papavasiliou, V., Rhim, J.S., Horst, R.L., Kremer, R. Mol. Cancer Res. (2002) [Pubmed]
  17. Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Panda, D.K., Miao, D., Tremblay, M.L., Sirois, J., Farookhi, R., Hendy, G.N., Goltzman, D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  18. 25-hydroxyvitamin D 1alpha-hydroxylase: structure of the mouse gene, chromosomal assignment, and developmental expression. Panda, D.K., Al Kawas, S., Seldin, M.F., Hendy, G.N., Goltzman, D. J. Bone Miner. Res. (2001) [Pubmed]
  19. Intestinal and renal adaptation to a low-Pi diet of type II NaPi cotransporters in vitamin D receptor- and 1alphaOHase-deficient mice. Capuano, P., Radanovic, T., Wagner, C.A., Bacic, D., Kato, S., Uchiyama, Y., St-Arnoud, R., Murer, H., Biber, J. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  20. Vitamin D(3) receptor ablation alters mammary gland morphogenesis. Zinser, G., Packman, K., Welsh, J. Development (2002) [Pubmed]
  21. Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity. van de Graaf, S.F., van der Kemp, A.W., van den Berg, D., van Oorschot, M., Hoenderop, J.G., Bindels, R.J. J. Am. Soc. Nephrol. (2006) [Pubmed]
  22. Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter. Brenza, H.L., Kimmel-Jehan, C., Jehan, F., Shinki, T., Wakino, S., Anazawa, H., Suda, T., DeLuca, H.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  23. Abnormal regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in X-linked hypophosphatemia: a translational or post-translational defect. Fujiwara, I., Aravindan, R., Horst, R.L., Drezner, M.K. J. Bone Miner. Res. (2003) [Pubmed]
  24. Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals. Murayama, A., Takeyama, K., Kitanaka, S., Kodera, Y., Kawaguchi, Y., Hosoya, T., Kato, S. Endocrinology (1999) [Pubmed]
  25. Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli. Sawada, N., Sakaki, T., Kitanaka, S., Takeyama, K., Kato, S., Inouye, K. Eur. J. Biochem. (1999) [Pubmed]
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