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Gene Review

COPA  -  coatomer protein complex, subunit alpha

Homo sapiens

Synonyms: Alpha-COP, Alpha-coat protein, Coatomer subunit alpha, HEP-COP, HEPCOP
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Disease relevance of COPA


High impact information on COPA

  • All patients were randomized to receive a four-drug cytotoxic chemotherapy regimen including cyclophosphamide, doxorubicin, vincristine and prednisone in 4-week cycles with or without IFN-alpha2a in addition (COPA vs I-COPA) [4].
  • Both COPA isomers incorporate readily into vesicles and membranes (K(p) approximately 10(6)) and align parallel to the lipids. t-COPA distributes homogeneously between gel and fluid lipid domains and the changes in polarization accurately reflect the lipid T(m) values [5].
  • RT-PCR analysis revealed no differential expression of HEP-COP in 14 human cancer cell lines, as compared with normal control cells [1].
  • Northern blot hybridization demonstrated that HEP-COP was expressed in a wide range of human adult and fetal tissues [1].
  • We previously sequenced the 4333-nucleotide cDNA of the COPA (HEP-COP) gene which encodes the human homologue of the alpha-subunit of the coatomer protein complex, involved in intracellular protein transport [6].

Biological context of COPA

  • Here we report the genomic organization of COPA, which contains 33 exons ranging in size from 67 to 611 bp [7].
  • Mapped by PCR and cycle sequencing, all the exon-intron junctions conformed with the GT-AG rule, the 32 introns ranging from about 80 bp to 4 kbp, with the genomic DNA of COPA estimated to span approximately 37 kb [7].
  • COPA was mapped by fluorescence in situ hybridization to chromosome region 1q23-->q25 [7].
  • From the Hep3B human hepatocellular carcinoma cell line, we have previously isolated and sequenced the cDNA of a novel gene, HEP-COP, whose predicted amino acid sequence, calculated relative molecular mass, and hydrophilicity are strikingly similar to the 160-kD alpha-subunit of the coatomer complex in yeast [8].
  • This observation, and the demonstrated activity of IFN-alpha-2a plus COPA (I-COPA) in low and intermediate grade histology nonHodgkin's lymphomas, provides the basis for the randomized Phase III trial comparing COPA to I-COPA in these neoplasms, which is currently being conducted in the Eastern Cooperative Oncology Group [9].

Associations of COPA with chemical compounds


Other interactions of COPA

  • Myelotoxicity was greater with CPOB than COPB, but comparable to COPA [10].

Analytical, diagnostic and therapeutic context of COPA

  • Six of the 12 patients were treated with the combination chemotherapy regimen COPA and received CNS prophylaxis; their survival was slightly longer than that of the other patients, who were treated with a variety of treatment regimens [14].
  • These alternatives include the laryngeal mask airway (LMA; LMA North America, San Diego, CA), cuffed oropharyngeal airway (COPA; Mallinckrodt, St. Louis, MO), and Combitube (Kendall-Sheridan, Mansfield, MA), that have been designed to act as bridges to establish an airway [15].
  • Future developments may include more widespread evaluation of the COPA in resuscitation and direct comparisons with other devices [16].
  • However, most inexperienced hospital basic life support providers can use the COPA effectively with minimal instruction [16].
  • Blood gas analysis: its correlation with patent airway using COPA/LMA [17].


  1. HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex. Chow, V.T., Quek, H.H. Gene (1996) [Pubmed]
  2. Bioinformatics approach leads to the discovery of the TMPRSS2:ETS gene fusion in prostate cancer. Rubin, M.A., Chinnaiyan, A.M. Lab. Invest. (2006) [Pubmed]
  3. Chemotherapy followed by consolidation radiation therapy for the treatment of clinical stage II aggressive histologic type non-Hodgkin's lymphoma. O'Connell, M.J., Harrington, D.P., Earle, J.D., Johnson, G.J., Glick, J.H., Neiman, R.S., Silverstein, M.N. Cancer (1988) [Pubmed]
  4. Final analysis of the ECOG I-COPA trial (E6484) in patients with non-Hodgkin's lymphoma treated with interferon alfa (IFN-alpha2a) plus an anthracycline-based induction regimen. Smalley, R.V., Weller, E., Hawkins, M.J., Oken, M.M., O'Connell, M.J., Haase-Statz, S., Borden, E.C. Leukemia (2001) [Pubmed]
  5. New fluorescent octadecapentaenoic acids as probes of lipid membranes and protein-lipid interactions. Mateo, C.R., Souto, A.A., Amat-Guerri, F., Acuña, A.U. Biophys. J. (1996) [Pubmed]
  6. Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin. Chow, V.T., Quek, H.H. Ann. Hum. Genet. (1997) [Pubmed]
  7. Genomic organization and mapping of the human HEP-COP gene (COPA) to 1q. Quek, H.H., Chow, V.T. Cytogenet. Cell Genet. (1997) [Pubmed]
  8. Molecular and cellular studies of the human homolog of the 160-kD alpha-subunit of the coatomer protein complex. Quek, H.H., Chow, V.T. DNA Cell Biol. (1997) [Pubmed]
  9. A phase I trial of interferon-alpha-2a plus cyclophosphamide, vincristine, prednisone, and doxorubicin. Schiller, J.H., Hawkins, M.J., O'Connell, M.J., Sielaff, K., Borden, E.C. Journal of biological response modifiers. (1989) [Pubmed]
  10. Sequential cyclophosphamide-prednisone and vincristine-bleomycin (CPOB). An effective, schedule-dependent treatment for advanced diffuse histiocytic lymphoma. Johnson, G.J., Costello, W.G., Oken, M.M., Sponzo, R.W., Barnes, J.M., Ezdinli, E.Z., Bennett, J.M., Silverstein, M.N., Glick, J.H., Berard, C.W. Cancer (1983) [Pubmed]
  11. Coping with COPA (Control of Pollution Act) in hospitals. Townsend, W.K. The Journal of the Institute of Hospital Engineering. (1988) [Pubmed]
  12. Esthesioneuroblastoma or malignant lymphoma? A case report. Falkson, C.B. Am. J. Clin. Oncol. (1988) [Pubmed]
  13. Activity of plant extracts on the respiratory burst and the stress protein synthesis. Pérez-García, F., Marín, E., Adzet, T., Cañigueral, S. Phytomedicine (2001) [Pubmed]
  14. Lymphoblastic lymphoma in adults. Streuli, R.A., Kaneko, Y., Variakojis, D., Kinnealey, A., Golomb, H.M., Rowley, J.D. Cancer (1981) [Pubmed]
  15. Bridges to establish an emergency airway and alternate intubating techniques. Foley, L.J., Ochroch, E.A. Critical care clinics. (2000) [Pubmed]
  16. The cuffed oropharyngeal airway in resuscitation. Rees, S.G. Anaesthesiologie und Reanimation. (2001) [Pubmed]
  17. Blood gas analysis: its correlation with patent airway using COPA/LMA. Gupta, R., Ghei, A., Chhabra, B. Middle East journal of anesthesiology. (2002) [Pubmed]
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