Disease relevance of Rxfp2

• Mutations of Insl3 or Great cause cryptorchidism (undescended testes) in mice [1].
• At concentrations ranging from 2.5 to 75.8 micrograms/ml, M12325 inhibited the cytopathic effects of 10 mean tissue culture infective doses of influenza virus A/WSN, A/FM, A/Kumamoto, and B/Great Lakes; parainfluenza virus; rhinovirus; echovirus; respiratory syncytial virus; and vesicular stomatitis virus [2].
• Twice daily oral doses for 14 days effected significant reductions in the mortality of mice infected intranasally with influenza A/WSN, A/FM, A/Kumamoto, and B/Great Lakes, and parainfluenza virus, but they were not effective in mice infected with herpes simplex virus [2].
• Marked differences in levles of viremia were not observed among Black-crowned Night Herons, Great Egrets, or Snowy Egrets [3].
• Between 1 January 1998 and 31 October 2001, 1247 sheep, clinically suspected of scrapie, were found to be positive by statutory tests in Great Britain. Archived brain tissue from these cases was retested by using these discriminatory methods [4].

High impact information on Rxfp2

• This study confirms that woodland rodents can maintain A. phagocytophila in Great Britain in the absence of other reservoir hosts and suggests that I. trianguliceps is a competent vector [5].
• Double mutant males have normal-sized prostate and testes, suggesting that Lgr8 does not account for differences in Rln1-/- and Lgr7-/- phenotypes [6].
• Lgr7-deficient females with additional deletion of Lgr8 (Great), another putative receptor for RLN, are fertile and have normal-sized litters [6].
• We have also identified a novel allele of LGR8 (R223K) found in one patient with retractile testes [7].
• Efficacy testing of WR-2721 in Great Britain everything is black and white at the gray lab [8].

Biological context of Rxfp2

• A transgene insertional mutation found on chromosome 5 in the mouse, known as crsp, causes deletion of a transmembrane G protein-coupled receptor gene, Great, which is highly expressed in the gubernaculum [9].
• This was due to eutrophication of the pond, following the influx of untreated sewage related to damage from the Great Hanshinn Earthquake of January 1995 [10].
• As part of a toxicology study, we fed groups of mice three different diets for 10 weeks: marine fish, 58% homogenized Atlantic smelt and herring; freshwater fish, 58% smelt and alewife from the North American Great Lakes, and commercial dry rodent chow [11].

Anatomical context of Rxfp2

• Further experiments on this mixture with Italian Great Newts and on the carbon tetrafluoride mixtures CF4-Ar and CF4-SF6 with mice suggested that the anomalous potencies may arise from specific pulmonary effects associated with the breathing of SF6 accompanied by a high pressure of some other gas [12].
• One hundred and six samples of brain, at the level of the medulla oblongata, and spinal cord, derived from the experimental study of the pathogenesis of BSE carried out in Great Britain between 1991 and 1995, were examined [13].
• Proteomic analysis of mdx skeletal muscle: Great reduction of adenylate kinase 1 expression and enzymatic activity [14].

Associations of Rxfp2 with chemical compounds

• Aqueous and/or aqueous ethanol extracts were made of 58 scleractinian species from 11 families, collected from Heron Island, Great Barrier Reef [15].
• 1. Methylaplysinopsin is an indolyl-methylene derivative of creatinin which was isolated from a sponge collected on the Great Barrier Reef [16].
• Octachlorostyrene (OCS) is an environmental contaminant, present in fish of Northern European waters and the Great Lakes of America. It has many distribution and toxic similarities to hexachlorobenzene (HCB) [17].

Other interactions of Rxfp2

• Our data indicate that neither Insl3 nor Lgr8 contribute to the RLN signaling pathway [6].
• The authors describe here a detailed analysis of the testicular descent and gubernacular development in crsp mice to determine the role of the Great gene in this process [9].

Analytical, diagnostic and therapeutic context of Rxfp2

• CONCLUSIONS: Great insights into the pathology of chronic obstructive lung disease have been made using various animal models [18].
• Viruses isolated from field outbreaks of disease in racing pigeons in continental Europe and Great Britain were shown to be identical by serological tests using conventional chicken antisera and mouse monoclonal antibodies [19].
• Members of the Chenuda group differed from the Great Island group in their ability to produce plaques in Xenopus cell cultures and in the time taken to produce clinical signs in infected mice [20].
• The Eurasian badger (Meles meles) is a significant wildlife reservoir of Mycobacterium bovis in Great Britain. Improved control strategies against the disease in badgers require the development of diagnostic tests and vaccines [21].
• We examined the impact of season and habitat on Sin Nombre virus (SNV) seroprevalence in deer mice (Peromyscus maniculatus) in Utah's Great Basin Desert from May 2002 through summer 2003 [22].

References