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Gene Review

Rxfp2  -  relaxin/insulin-like family peptide...

Mus musculus

Synonyms: G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Gpr106, Great, LGR8, ...
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Disease relevance of Rxfp2


High impact information on Rxfp2

  • This study confirms that woodland rodents can maintain A. phagocytophila in Great Britain in the absence of other reservoir hosts and suggests that I. trianguliceps is a competent vector [5].
  • Double mutant males have normal-sized prostate and testes, suggesting that Lgr8 does not account for differences in Rln1-/- and Lgr7-/- phenotypes [6].
  • Lgr7-deficient females with additional deletion of Lgr8 (Great), another putative receptor for RLN, are fertile and have normal-sized litters [6].
  • We have also identified a novel allele of LGR8 (R223K) found in one patient with retractile testes [7].
  • Efficacy testing of WR-2721 in Great Britain everything is black and white at the gray lab [8].

Biological context of Rxfp2

  • A transgene insertional mutation found on chromosome 5 in the mouse, known as crsp, causes deletion of a transmembrane G protein-coupled receptor gene, Great, which is highly expressed in the gubernaculum [9].
  • This was due to eutrophication of the pond, following the influx of untreated sewage related to damage from the Great Hanshinn Earthquake of January 1995 [10].
  • As part of a toxicology study, we fed groups of mice three different diets for 10 weeks: marine fish, 58% homogenized Atlantic smelt and herring; freshwater fish, 58% smelt and alewife from the North American Great Lakes, and commercial dry rodent chow [11].

Anatomical context of Rxfp2


Associations of Rxfp2 with chemical compounds

  • Aqueous and/or aqueous ethanol extracts were made of 58 scleractinian species from 11 families, collected from Heron Island, Great Barrier Reef [15].
  • 1. Methylaplysinopsin is an indolyl-methylene derivative of creatinin which was isolated from a sponge collected on the Great Barrier Reef [16].
  • Octachlorostyrene (OCS) is an environmental contaminant, present in fish of Northern European waters and the Great Lakes of America. It has many distribution and toxic similarities to hexachlorobenzene (HCB) [17].

Other interactions of Rxfp2

  • Our data indicate that neither Insl3 nor Lgr8 contribute to the RLN signaling pathway [6].
  • The authors describe here a detailed analysis of the testicular descent and gubernacular development in crsp mice to determine the role of the Great gene in this process [9].

Analytical, diagnostic and therapeutic context of Rxfp2


  1. GREAT/LGR8 is the only receptor for insulin-like 3 peptide. Bogatcheva, N.V., Truong, A., Feng, S., Engel, W., Adham, I.M., Agoulnik, A.I. Mol. Endocrinol. (2003) [Pubmed]
  2. Antiviral activity of sodium 5-aminosulfonyl-2,4-dichlorobenzoate (M12325). Ohnishi, H., Yamaguchi, K., Shimada, S., Himuro, S., Suzuki, Y. Antimicrob. Agents Chemother. (1982) [Pubmed]
  3. Viremia in young herons and ibis infected with Venezuelan encephalitis virus. Dickerman, R.W., Bonacorsa, C.M., Scherer, W.F. Am. J. Epidemiol. (1976) [Pubmed]
  4. Monitoring for bovine spongiform encephalopathy in sheep in Great Britain, 1998-2004. Stack, M., Jeffrey, M., Gubbins, S., Grimmer, S., González, L., Martin, S., Chaplin, M., Webb, P., Simmons, M., Spencer, Y., Bellerby, P., Hope, J., Wilesmith, J., Matthews, D. J. Gen. Virol. (2006) [Pubmed]
  5. Seasonal dynamics of Anaplasma phagocytophila in a rodent-tick (Ixodes trianguliceps) system, United Kingdom. Bown, K.J., Begon, M., Bennett, M., Woldehiwet, Z., Ogden, N.H. Emerging Infect. Dis. (2003) [Pubmed]
  6. Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Kamat, A.A., Feng, S., Bogatcheva, N.V., Truong, A., Bishop, C.E., Agoulnik, A.I. Endocrinology (2004) [Pubmed]
  7. T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane. Bogatcheva, N.V., Ferlin, A., Feng, S., Truong, A., Gianesello, L., Foresta, C., Agoulnik, A.I. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  8. Efficacy testing of WR-2721 in Great Britain everything is black and white at the gray lab. Yuhas, J.M. Int. J. Radiat. Oncol. Biol. Phys. (1983) [Pubmed]
  9. Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor. Tomiyama, H., Hutson, J.M., Truong, A., Agoulnik, A.I. J. Pediatr. Surg. (2003) [Pubmed]
  10. Possible cause of unnatural mass death of wild birds in a pond in Nishinomiya, Japan: sudden appearance of toxic cyanobacteria. Matsunaga, H., Harada, K.I., Senma, M., Ito, Y., Yasuda, N., Ushida, S., Kimura, Y. Nat. Toxins (1999) [Pubmed]
  11. A marine fish diet reduces spontaneous lymphoma in outbred Swiss-Webster mice. Somers, C.M., Kwiecien, J.M., Quinn, J.S. Leuk. Lymphoma (2005) [Pubmed]
  12. Potency of mixtures of general anaesthetic agents. Clarke, R.F., Daniels, S., Harrison, C.B., Jordan, M.J., Paton, W.D., Smith, E.B., Smith, R.A. British journal of anaesthesia. (1978) [Pubmed]
  13. Rapid test for the preclinical postmortem diagnosis of BSE in central nervous system tissue. Grassi, J., Comoy, E., Simon, S., Créminon, C., Frobert, Y., Trapmann, S., Schimmel, H., Hawkins, S.A., Moynagh, J., Deslys, J.P., Wells, G.A. Vet. Rec. (2001) [Pubmed]
  14. Proteomic analysis of mdx skeletal muscle: Great reduction of adenylate kinase 1 expression and enzymatic activity. Ge, Y., Molloy, M.P., Chamberlain, J.S., Andrews, P.C. Proteomics (2003) [Pubmed]
  15. Widespread but variable toxicity in scleractinian corals. Gunthorpe, L., Cameron, A.M. Toxicon (1990) [Pubmed]
  16. Methylaplysinopsin: a natural product of marine origin with effects on serotonergic neurotransmission. Baird-Lambert, J., Davis, P.A., Taylor, K.M. Clin. Exp. Pharmacol. Physiol. (1982) [Pubmed]
  17. Influence of iron on the induction of hepatic tumors and porphyria by octachlorostyrene in C57BL/10ScSn mice. Smith, A.G., Carthew, P., Francis, J.E., Ingebrigtsen, K. Cancer Lett. (1994) [Pubmed]
  18. Animal models of cigarette smoke-induced COPD. Wright, J.L., Churg, A. Chest (2002) [Pubmed]
  19. Paramyxovirus type 1 infections of racing pigeons: 1 characterisation of isolated viruses. Alexander, D.J., Russell, P.H., Collins, M.S. Vet. Rec. (1984) [Pubmed]
  20. Characterization of orbiviruses of the Kemerovo serogroup: isolations and serological comparisons. Jacobs, S.C., Carey, D., Chastel, C., Schwan, T.G., Nuttall, P.A. Arch. Virol. (1986) [Pubmed]
  21. A lymphocyte transformation assay for the detection of Mycobacterium bovis infection in the Eurasian badger (Meles meles). Dalley, D., Chambers, M.A., Cockle, P., Pressling, W., Gavier-Widén, D., Hewinson, R.G. Vet. Immunol. Immunopathol. (1999) [Pubmed]
  22. Changes in sin nombre virus antibody prevalence in deer mice across seasons: the interaction between habitat, sex, and infection in deer mice. Pearce-Duvet, J.M., St Jeor, S.C., Boone, J.D., Dearing, M.D. J. Wildl. Dis. (2006) [Pubmed]
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