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Gene Review

SLC17A7  -  solute carrier family 17 (vesicular...

Homo sapiens

Synonyms: BNPI, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 7, VGLUT1, VGluT1, ...
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Disease relevance of SLC17A7

  • Here, we show that platelets express the pre-synaptic markers VGLUT1 and VGLUT2 and release glutamate following aggregation, implying a possible contributory role in the pathophysiology of stroke, migraine, and other excitotoxic disorders [1].
  • Confocal analysis of spinal cord sections at 8 weeks-12 months after ischemia revealed a continuing presence of ChAT positive alpha-motoneurons, Ia afferents and VGLUT2 and VGLUT1-positive terminals but a selective loss of small presumably inhibitory interneurons between laminae V-VII [2].

Psychiatry related information on SLC17A7


High impact information on SLC17A7

  • Stimulation of exocytosis--fusion of the vesicles with the cell membrane and release of their contents--resulted in quantal release of glutamate from BNPI-expressing cells [4].
  • Furthermore, we expressed BNPI in neurons containing GABA (gamma-aminobutyric acid) and maintained them as cultures of single, isolated neurons that form synapses to themselves [4].
  • We conclude that BNPI functions as vesicular glutamate transporter and that expression of BNPI suffices to define a glutamatergic phenotype in neurons [4].
  • VGLUT3 also differs from VGLUT1 and VGLUT2 in its subcellular location, with somatodendritic as well as axonal expression [5].
  • The predicted amino acid sequence of hVGLUT3 shows 72% identity to both hVGLUT1 and hVGLUT2. hVGLUT3 functions as a vesicular glutamate transporter with similar properties to the other isoforms when it is heterologously expressed in a neuroendocrine cell line [6].

Biological context of SLC17A7


Anatomical context of SLC17A7


Associations of SLC17A7 with chemical compounds

  • Recently, two mammalian isoforms of a vesicular glutamate transporter, VGLUT1 and VGLUT2, have been identified, the expression of which enables quantal release of glutamate from glutamatergic neurons [6].
  • Identification of Endophilins 1 and 3 as Selective Binding Partners for VGLUT1 and Their Co-Localization in Neocortical Glutamatergic Synapses: Implications for Vesicular Glutamate Transporter Trafficking and Excitatory Vesicle Formation [11].
  • Within the myenteric neuropil we found, besides co-localization of VGLUT1 and substance P, no further co-localization of VGLUT1-ir with any of these markers [12].

Co-localisations of SLC17A7


Regulatory relationships of SLC17A7


Other interactions of SLC17A7

  • Although mammalian VGLUT1 and VGLUT2 exhibit a complementary expression pattern covering all glutamatergic pathways in the CNS, expression of hVGLUT3 overlaps with them in some brain areas, suggesting molecular diversity that may account for physiological heterogeneity in glutamatergic synapses [6].
  • In schizophrenia, VGLUT1 mRNA was decreased in hippocampal formation and DPFC, complexin II mRNA was reduced in DPFC and STC, and complexin I mRNA decreased in STC [14].
  • Bidirectional and opposite activity-dependent regulation of VGLUT1 and VIAAT expression would serve to adjust the balance of glutamate and GABA release and therefore the level of postsynaptic receptor saturation [15].
  • We screened a yeast two-hybrid library with bait containing the C-terminal amino acids of VGLUT1 and obtained clones that encode endophilin 1 and endophilin 3, proteins considered to play an integral role in glutamatergic vesicle formation [11].
  • We show that chronic excitatory synapse deprivation generates an excitable CA3 network where enhanced amplitude and frequency of spontaneous excitatory post-synaptic potentials were associated with increased glutamate receptor subunit expression and increased number and size of synapsin 1 and VGLUT1 positive puncta [16].

Analytical, diagnostic and therapeutic context of SLC17A7


  1. Human platelets express the synaptic markers VGLUT1 and 2 and release glutamate following aggregation. Tremolizzo, L., DiFrancesco, J.C., Rodriguez-Menendez, V., Sirtori, E., Longoni, M., Cassetti, A., Bossi, M., El Mestikawy, S., Cavaletti, G., Ferrarese, C. Neurosci. Lett. (2006) [Pubmed]
  2. Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Kakinohana, O., Hefferan, M.P., Nakamura, S., Kakinohana, M., Galik, J., Tomori, Z., Marsala, J., Yaksh, T.L., Marsala, M. Neuroscience (2006) [Pubmed]
  3. Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter. Ni, B., Du, Y., Wu, X., DeHoff, B.S., Rosteck, P.R., Paul, S.M. J. Neurochem. (1996) [Pubmed]
  4. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Takamori, S., Rhee, J.S., Rosenmund, C., Jahn, R. Nature (2000) [Pubmed]
  5. VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Fremeau, R.T., Voglmaier, S., Seal, R.P., Edwards, R.H. Trends Neurosci. (2004) [Pubmed]
  6. Molecular cloning and functional characterization of human vesicular glutamate transporter 3. Takamori, S., Malherbe, P., Broger, C., Jahn, R. EMBO Rep. (2002) [Pubmed]
  7. Characterization of vesicular glutamate transporter in pancreatic alpha - and beta -cells and its regulation by glucose. Bai, L., Zhang, X., Ghishan, F.K. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  8. Differential development of vesicular glutamate transporters in brain: an in vitro study of cerebellar granule cells. Hallberg, O.E., Bogen, I.L., Reistad, T., Haug, K.H., Wright, M.S., Fonnum, F., Walaas, S.I. Neurochem. Int. (2006) [Pubmed]
  9. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. Aihara, Y., Mashima, H., Onda, H., Hisano, S., Kasuya, H., Hori, T., Yamada, S., Tomura, H., Yamada, Y., Inoue, I., Kojima, I., Takeda, J. J. Neurochem. (2000) [Pubmed]
  10. Cellular resistance to Evans blue toxicity involves an up-regulation of a phosphate transporter implicated in vesicular glutamate storage. Israël, M., Tomasi, M., Bostel, S., Meunier, F.M. J. Neurochem. (2001) [Pubmed]
  11. Identification of Endophilins 1 and 3 as Selective Binding Partners for VGLUT1 and Their Co-Localization in Neocortical Glutamatergic Synapses: Implications for Vesicular Glutamate Transporter Trafficking and Excitatory Vesicle Formation. De Gois, S., Jeanclos, E., Morris, M., Grewal, S., Varoqui, H., Erickson, J.D. Cell. Mol. Neurobiol. (2006) [Pubmed]
  12. Vesicular glutamate transporter 1 immunoreactivity in extrinsic and intrinsic innervation of the rat esophagus. Ewald, P., Neuhuber, W.L., Raab, M. Histochem. Cell Biol. (2006) [Pubmed]
  13. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). Takamori, S., Rhee, J.S., Rosenmund, C., Jahn, R. J. Neurosci. (2001) [Pubmed]
  14. Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. Eastwood, S.L., Harrison, P.J. Schizophr. Res. (2005) [Pubmed]
  15. Activity-dependent regulation of vesicular glutamate and GABA transporters: a means to scale quantal size. Erickson, J.D., De Gois, S., Varoqui, H., Schafer, M.K., Weihe, E. Neurochem. Int. (2006) [Pubmed]
  16. Network stability through homeostatic scaling of excitatory and inhibitory synapses following inactivity in CA3 of rat organotypic hippocampal slice cultures. Buckby, L.E., Jensen, T.P., Smith, P.J., Empson, R.M. Mol. Cell. Neurosci. (2006) [Pubmed]
  17. Expression of vesicular glutamate transporter 1 immunoreactivity in peripheral and central endings of trigeminal mesencephalic nucleus neurons in the rat. Pang, Y.W., Li, J.L., Nakamura, K., Wu, S., Kaneko, T., Mizuno, N. J. Comp. Neurol. (2006) [Pubmed]
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