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Gene Review

ADRA2B  -  adrenoceptor alpha 2B

Homo sapiens

Synonyms: ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, Alpha-2 adrenergic receptor subtype C2, ...
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Disease relevance of ADRA2B


High impact information on ADRA2B

  • We have isolated a cDNA clone (RB alpha 2B) and its homologous gene (GR alpha 2B) encoding an alpha 2B-adrenergic receptor subtype by screening a rat brain cDNA and a rat genomic library [2].
  • We provide a simultaneous reconstruction of phylogeny and age of the four radiations based on a 3.5-kb data set from three nuclear genes (ADRA2B, vWF, and AR) [3].
  • Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization [4].
  • In this study we investigated whether the 12Glu9 polymorphism in the gene encoding the alpha2B-adrenergic receptor ( ADRA2B) is associated with insulin secretion and/or the incidence of Type 2 diabetes in individuals with impaired glucose tolerance [5].
  • Several common polymorphisms (>10% minor allele frequency) at ADRA2B (insertion/deletion polymorphism [Glu 322-325 ], G-98C, C1182A, and C1776A) did not show an association with either B max or K d for the drug response [6].

Biological context of ADRA2B

  • Cardiovascular and metabolic phenotypes in relation to the ADRA2B insertion/deletion polymorphism in a Chinese population [7].
  • CONCLUSION: In Chinese men, the I allele of the ADRA2B gene is associated with higher blood pressure, but also with a more favourable metabolic phenotype [7].
  • Subtype-specific probes to the murine homologs of the human ADRA2B and ADRA2C genes were prepared by PCR amplification and used to map these two genes to mouse chromosomes 2 and 5, respectively [8].
  • ADRA2A and ADRA2B each had a single haplotype block at least 11 and 16 kb in size, respectively, in both populations [9].
  • In contrast, inhibition curves for both ligands in the human caudate nucleus were consistent with a model of two classes of binding sites in approximately equal proportions, suggesting that this tissue contains approximately equal densities of the alpha-2A and alpha-2B adrenergic receptor subtypes [10].

Anatomical context of ADRA2B


Associations of ADRA2B with chemical compounds


Other interactions of ADRA2B


Analytical, diagnostic and therapeutic context of ADRA2B


  1. The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2. McClue, S.J., Milligan, G. FEBS Lett. (1990) [Pubmed]
  2. Cloning and expression of a rat brain alpha 2B-adrenergic receptor. Flordellis, C.S., Handy, D.E., Bresnahan, M.R., Zannis, V.I., Gavras, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. Asynchronous colonization of Madagascar by the four endemic clades of primates, tenrecs, carnivores, and rodents as inferred from nuclear genes. Poux, C., Madsen, O., Marquard, E., Vieites, D.R., de Jong, W.W., Vences, M. Syst. Biol. (2005) [Pubmed]
  4. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. Small, K.M., Brown, K.M., Forbes, S.L., Liggett, S.B. J. Biol. Chem. (2001) [Pubmed]
  5. Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study. Siitonen, N., Lindström, J., Eriksson, J., Valle, T.T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Tuomilehto, J., Laakso, M., Uusitupa, M. Diabetologia (2004) [Pubmed]
  6. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. King, D., Etzel, J.P., Chopra, S., Smith, J., Cadman, P.E., Rao, F., Funk, S.D., Rana, B.K., Schork, N.J., Insel, P.A., O'Connor, D.T. Clin. Pharmacol. Ther. (2005) [Pubmed]
  7. Cardiovascular and metabolic phenotypes in relation to the ADRA2B insertion/deletion polymorphism in a Chinese population. Zhang, H., Li, X., Huang, J., Li, Y., Thijs, L., Wang, Z., Lu, X., Cao, K., Xie, S., Staessen, J.A., Wang, J.G. J. Hypertens. (2005) [Pubmed]
  8. Assignment of two alpha 2 adrenoceptor subtype genes to murine chromosomes. Chang, N.C., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Chang, Y.H., Chen, W.M., Chang, A.C. Neurosci. Lett. (1994) [Pubmed]
  9. Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. Belfer, I., Buzas, B., Hipp, H., Phillips, G., Taubman, J., Lorincz, I., Evans, C., Lipsky, R.H., Enoch, M.A., Max, M.B., Goldman, D. J. Hum. Genet. (2005) [Pubmed]
  10. Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain. Petrash, A.C., Bylund, D.B. Life Sci. (1986) [Pubmed]
  11. Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. Schambra, U.B., Mackensen, G.B., Stafford-Smith, M., Haines, D.E., Schwinn, D.A. Neuroscience (2005) [Pubmed]
  12. alpha 2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels. Smith, M.S., Schambra, U.B., Wilson, K.H., Page, S.O., Hulette, C., Light, A.R., Schwinn, D.A. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  13. The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype. Gobbi, M., Frittoli, E., Mennini, T. Naunyn Schmiedebergs Arch. Pharmacol. (1990) [Pubmed]
  14. Adipocyte alpha 2A-adrenoceptor is the only alpha 2-adrenoceptor regulated by testosterone. Bouloumié, A., Valet, P., Daviaud, D., Prats, H., Lafontan, M., Saulnier-Blache, J.S. Eur. J. Pharmacol. (1994) [Pubmed]
  15. Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors. Okusa, M.D., Huang, L., Momose-Hotokezaka, A., Huynh, L.P., Mangrum, A.J. Am. J. Physiol. (1997) [Pubmed]
  16. ADRA2B gene insertion/deletion polymorphism and artery compliance. Zhang, H.F., Li, X.L., Xie, S.F., Zhu, J., Wang, Z.Z., Liang, L.R., Cao, K.J., De, W., Yuan, L., Huang, J. Chin. Med. J. (2005) [Pubmed]
  17. Subtype classification of presynaptic alpha 2-adrenoceptors. Alberts, P. Gen. Pharmacol. (1993) [Pubmed]
  18. Regional distribution of alpha 2A- and alpha 2B-adrenoceptor subtypes in postmortem human brain. De Vos, H., Vauquelin, G., De Keyser, J., De Backer, J.P., Van Liefde, I. J. Neurochem. (1992) [Pubmed]
  19. Molecular evolution of the mammalian alpha 2B adrenergic receptor. Madsen, O., Willemsen, D., Ursing, B.M., Arnason, U., de Jong, W.W. Mol. Biol. Evol. (2002) [Pubmed]
  20. Adrenergic receptors and their signal transduction mechanisms in hypertension. Brodde, O.E., Michel, M.C. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. (1992) [Pubmed]
  21. Characterization of prazosin-sensitive alpha 2 B-adrenoceptors expressed by cultured rat IMCD cells. Yasuda, G., Sun, L., Umemura, S., Pettinger, W.A., Jeffries, W.B. Am. J. Physiol. (1991) [Pubmed]
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