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Gene Review

Casp12  -  caspase 12

Rattus norvegicus

Synonyms: CASP-12, Caspase-12
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Disease relevance of Casp12


High impact information on Casp12


Chemical compound and disease context of Casp12


Anatomical context of Casp12


Associations of Casp12 with chemical compounds


Other interactions of Casp12

  • Caspase-12, localized in the SR, is considered a central caspase, and its activation by cleavage via calpain indicates activation of the SR-mediated pathway of apoptosis [9].
  • Of various apoptotic pathways, Fas activations, 8-OHdG expression, and caspase-12 were demonstrated in type 1 diabetic BB/Wor rats only [13].
  • In contrast, in CGN, although a drastic increase in the expression of GRP78 was found as was the case in HPN, no up-regulation of caspase-12 was detected [14].

Analytical, diagnostic and therapeutic context of Casp12


  1. Increased expression and processing of caspase-12 after traumatic brain injury in rats. Larner, S.F., Hayes, R.L., McKinsey, D.M., Pike, B.R., Wang, K.K. J. Neurochem. (2004) [Pubmed]
  2. Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat. Mouw, G., Zechel, J.L., Gamboa, J., Lust, W.D., Selman, W.R., Ratcheson, R.A. Neuroreport (2003) [Pubmed]
  3. AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Terai, K., Hiramoto, Y., Masaki, M., Sugiyama, S., Kuroda, T., Hori, M., Kawase, I., Hirota, H. Mol. Cell. Biol. (2005) [Pubmed]
  4. Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis. Yang, L., Carlson, S.G., McBurney, D., Horton, W.E. J. Biol. Chem. (2005) [Pubmed]
  5. Na/Ca exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells. Diaz-Horta, O., Kamagate, A., Herchuelz, A., Van Eylen, F. Diabetes (2002) [Pubmed]
  6. Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide. Ferreiro, E., Oliveira, C.R., Pereira, C. J. Neurosci. Res. (2004) [Pubmed]
  7. Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12. Dirks, A.J., Leeuwenburgh, C. Free Radic. Biol. Med. (2004) [Pubmed]
  8. Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx. Das, A., Garner, D.P., Del Re, A.M., Woodward, J.J., Kumar, D.M., Agarwal, N., Banik, N.L., Ray, S.K. Brain Res. (2006) [Pubmed]
  9. Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats. Jang, Y.M., Kendaiah, S., Drew, B., Phillips, T., Selman, C., Julian, D., Leeuwenburgh, C. FEBS Lett. (2004) [Pubmed]
  10. Ester derivatives of tournefolic acid B attenuate N-methyl-D-aspartate-mediated excitotoxicity in rat cortical neurons. Wang, C.N., Pan, H.C., Lin, Y.L., Chi, C.W., Shiao, Y.J. Mol. Pharmacol. (2006) [Pubmed]
  11. Neuronal apoptosis induced by endoplasmic reticulum stress. Chen, L., Gao, X. Neurochem. Res. (2002) [Pubmed]
  12. The influence of phosphatidylinositol 3-kinase/Akt pathway on the ischemic injury during rat liver graft preservation. Li, X.L., Man, K., Ng, K.T., Sun, C.K., Lo, C.M., Fan, S.T. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2005) [Pubmed]
  13. The role of impaired insulin/IGF action in primary diabetic encephalopathy. Li, Z.G., Zhang, W., Sima, A.A. Brain Res. (2005) [Pubmed]
  14. Comparative study of endoplasmic reticulum stress-induced neuronal death in rat cultured hippocampal and cerebellar granule neurons. Kosuge, Y., Sakikubo, T., Ishige, K., Ito, Y. Neurochem. Int. (2006) [Pubmed]
  15. Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis. Kubisch, C.H., Sans, M.D., Arumugam, T., Ernst, S.A., Williams, J.A., Logsdon, C.D. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
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