Gene Review:
Bad - BCL2-associated agonist of cell death
Rattus norvegicus
Synonyms:
BAD, Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, Bcl2-associated agonist of cell death
- Akt/Bad signaling and motor neuron survival after spinal cord injury. Yu, F., Sugawara, T., Maier, C.M., Hsieh, L.B., Chan, P.H. Neurobiol. Dis. (2005)
- Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Ellert-Miklaszewska, A., Kaminska, B., Konarska, L. Cell. Signal. (2005)
- Estradiol prevents the injury-induced decrease of Akt activation and Bad phosphorylation. Won, C.K., Ha, S.J., Noh, H.S., Kang, S.S., Cho, G.J., Choi, W.S., Koh, P.O. Neurosci. Lett. (2005)
- Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis. Schaffer, S.W., Croft, C.B., Solodushko, V. Am. J. Physiol. Heart Circ. Physiol. (2000)
- Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Abe, T., Takagi, N., Nakano, M., Furuya, M., Takeo, S. Brain Res. (2004)
- Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Zundel, W., Giaccia, A. Genes Dev. (1998)
- Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. Guo, R.F., Huber-Lang, M., Wang, X., Sarma, V., Padgaonkar, V.A., Craig, R.A., Riedemann, N.C., McClintock, S.D., Hlaing, T., Shi, M.M., Ward, P.A. J. Clin. Invest. (2000)
- Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma. Huang, W., Fileta, J.B., Dobberfuhl, A., Filippopolous, T., Guo, Y., Kwon, G., Grosskreutz, C.L. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Kennedy, S.G., Kandel, E.S., Cross, T.K., Hay, N. Mol. Cell. Biol. (1999)
- Regulation of vascular smooth muscle cell apoptosis. Modulation of bad by a phosphatidylinositol 3-kinase-dependent pathway. Bai, H., Pollman, M.J., Inishi, Y., Gibbons, G.H. Circ. Res. (1999)
- C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici, C., Niculescu, F., Jensen, T., Zafranskaia, E., Fosbrink, M., Rus, V., Shin, M.L., Rus, H. J. Immunol. (2006)
- The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad. Shimamura, H., Terada, Y., Okado, T., Tanaka, H., Inoshita, S., Sasaki, S. J. Am. Soc. Nephrol. (2003)
- Selective involvement of the PI3K/PKB/bad pathway in retinal cell death. Campos, C.B., Bédard, P.A., Linden, R. J. Neurobiol. (2003)
- Functional characterization of two splice variants of rat bad and their interaction with Bcl-w in sympathetic neurons. Hamnér, S., Arumäe, U., Li-Ying, Y., Sun, Y.F., Saarma, M., Lindholm, D. Mol. Cell. Neurosci. (2001)
- Effects of acute ethanol exposure on regulatory mechanisms of Bcl-2-associated apoptosis promoter, bad, in neonatal rat cerebellum: differential effects during vulnerable and resistant developmental periods. Siler-Marsiglio, K.I., Madorsky, I., Pan, Q., Paiva, M., Neeley, A.W., Shaw, G., Heaton, M.B. Alcohol. Clin. Exp. Res. (2006)
- Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins. Moreau, C., Cartron, P.F., Hunt, A., Meflah, K., Green, D.R., Evan, G., Vallette, F.M., Juin, P. J. Biol. Chem. (2003)
- C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. Soane, L., Cho, H.J., Niculescu, F., Rus, H., Shin, M.L. J. Immunol. (2001)
- Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: a possible cause for erectile dysfunction in diabetes. Jesmin, S., Sakuma, I., Salah-Eldin, A., Nonomura, K., Hattori, Y., Kitabatake, A. J. Mol. Endocrinol. (2003)
- Suppression of mitochondria-dependent neutrophil apoptosis with thermal injury. Hu, Z., Sayeed, M.M. Am. J. Physiol., Cell Physiol. (2004)
- Idoxifene and estradiol enhance antiapoptotic activity through estrogen receptor-beta in cultured rat hepatocytes. Inoue, H., Shimizu, I., Lu, G., Itonaga, M., Cui, X., Okamura, Y., Shono, M., Honda, H., Inoue, S., Muramatsu, M., Ito, S. Dig. Dis. Sci. (2003)
- Interaction of 14-3-3 with Bid during seizure-induced neuronal death. Shinoda, S., Schindler, C.K., Quan-Lan, J., Saugstad, J.A., Taki, W., Simon, R.P., Henshall, D.C. J. Neurochem. (2003)
- Induction of apoptosis in rat ventral prostate by finasteride is associated with alteration in MAP kinase pathways and Bcl-2 related family of proteins. Huynh, H. Int. J. Oncol. (2002)
- Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9. Ge, Y., Belcher, S.M., Pierce, D.R., Light, K.E. Brain Res. Mol. Brain Res. (2004)