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Gene Review

Ivl  -  involucrin

Mus musculus

Synonyms: 1110019C06Rik, Involucrin
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Disease relevance of Ivl


High impact information on Ivl


Biological context of Ivl

  • RESULTS: The K14 and INV promoter constructs showed beta-galactosidase gene expression only in the epidermis, while the CMV promoter showed gene expression in both the dermis and epidermis [7].
  • Lines from group I (CK2, 3, 5 and their ras-transfected homologous lines) shared a typical epithelial phenotype in monolayer and the ability (a) to form an epithelium similar to a CIN-III lesion and (b) to strongly express keratins K1-K10 and involucrin in organotypic cultures [8].
  • Systematic repeat addition at a precise location in the coding region of the involucrin gene of wild mice reveals their phylogeny [9].
  • Using beta-galactosidase as a reporter gene in transgenic mice, we observed specific activity of the involucrin promoter in the eyelid tip cells [10].
  • PKC eta-induced differentiation is accompanied by the transcriptional activation of transglutaminase I, a key enzyme in squamous differentiation, and involucrin, a precursor of cornified envelopes [11].

Anatomical context of Ivl


Associations of Ivl with chemical compounds


Co-localisations of Ivl


Regulatory relationships of Ivl


Other interactions of Ivl

  • Concurrently, there was diminished beta-glucocerebrosidase activity at the stratum granulosum-stratum corneum junction and a modest decrease in both involucrin and loricrin protein expression, markers of keratinocyte differentiation [24].
  • Conversely, TAp63 transcribed the upper layer's genes (Ets-1, K1, transglutaminases, involucrin) [25].
  • Analysis of the mice showed that no phenotypic effect was observed in mice expressing PAH and GTP-CH from the INV promoter [26].
  • We have previously described a transgenic mouse model of epidermal neoplasia wherein expression of a switchable form of c-Myc, MycER(TAM), is targeted to the postmitotic suprabasal keratinocytes of murine epidermis via the involucrin promoter [27].
  • The phenotypes examined include ODC enzymatic activity, doubling time, morphological change, anchorage dependent growth, tumorigenicity in nude mice, induction of epithelial differentiation marker protein (involucrin), and change of cell cycle position [28].

Analytical, diagnostic and therapeutic context of Ivl


  1. Malignant progression of an HPV16-immortalized human keratinocyte cell line (HPKIA) in vitro. Dürst, M., Seagon, S., Wanschura, S., zur Hausen, H., Bullerdiek, J. Cancer Genet. Cytogenet. (1995) [Pubmed]
  2. Transgenic mice expressing IFN-gamma in the epidermis have eczema, hair hypopigmentation, and hair loss. Carroll, J.M., Crompton, T., Seery, J.P., Watt, F.M. J. Invest. Dermatol. (1997) [Pubmed]
  3. Selective cyclooxygenase-2 inhibition does not alter keratinocyte wound responses in the mouse epidermis after abrasion. Hardy, M.M., Blomme, E.A., Lisowski, A., Chinn, K.S., Jones, A., Harmon, J.M., Opsahl, A., Ornberg, R.L., Tripp, C.S. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  4. Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis. Seery, J.P., Carroll, J.M., Cattell, V., Watt, F.M. J. Exp. Med. (1997) [Pubmed]
  5. Desmoglein isoform distribution affects stratum corneum structure and function. Elias, P.M., Matsuyoshi, N., Wu, H., Lin, C., Wang, Z.H., Brown, B.E., Stanley, J.R. J. Cell Biol. (2001) [Pubmed]
  6. Targeted ablation of the murine involucrin gene. Djian, P., Easley, K., Green, H. J. Cell Biol. (2000) [Pubmed]
  7. Differential expression of tissue-specific promoters by gene gun. Lin, M.T., Wang, F., Uitto, J., Yoon, K. Br. J. Dermatol. (2001) [Pubmed]
  8. Differentiation ability and oncogenic potential of HPV-33- and HPV-33 + ras-transfected keratinocytes. Gilles, C., Piette, J., Peter, W., Fusenig, N.E., Foidart, J.M. Int. J. Cancer (1994) [Pubmed]
  9. Systematic repeat addition at a precise location in the coding region of the involucrin gene of wild mice reveals their phylogeny. Djian, P., Delhomme, B. Genetics (2005) [Pubmed]
  10. Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusion. Carroll, J.M., Luetteke, N.C., Lee, D.C., Watt, F.M. Mech. Dev. (1998) [Pubmed]
  11. Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation. Kashiwagi, M., Ohba, M., Chida, K., Kuroki, T. J. Biochem. (2002) [Pubmed]
  12. Role of the nude gene in epithelial terminal differentiation. Baxter, R.M., Brissette, J.L. J. Invest. Dermatol. (2002) [Pubmed]
  13. Expression of terminal differentiation proteins defines stages of mouse mammary gland development. Mikaelian, I., Hovick, M., Silva, K.A., Burzenski, L.M., Shultz, L.D., Ackert-Bicknell, C.L., Cox, G.A., Sundberg, J.P. Vet. Pathol. (2006) [Pubmed]
  14. Spontaneous trichoepithelioma in a laboratory mouse: gross, microscopic and immunohistochemical findings. Martín de Las Mulas, J., Molina, A.M., Millán, Y., Carrasco, L., Moyano, R., Mozos, E. Lab. Anim. (2007) [Pubmed]
  15. Characterization of Corn1 mice: Alteration of epithelial and stromal cell gene expression. Wang, I., Kao, C.W., Liu, C., Saika, S., Nishina, P.M., Sundberg, J.P., Smith, R.S., Kao, W.W. Mol. Vis. (2001) [Pubmed]
  16. Expansion of mouse involucrin by intra-allelic repeat addition. Delhomme, B., Djian, P. Gene (2000) [Pubmed]
  17. Stratum-specific expression of human transferrin receptor increases iron in mouse epidermis. Milstone, L.M., Adams, B.D., Zhou, J., Bruegel Sanchez, V.L., Shofner, J. J. Invest. Dermatol. (2006) [Pubmed]
  18. Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion. Owens, D.M., Watt, F.M. Cancer Res. (2001) [Pubmed]
  19. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. De Paiva, C.S., Corrales, R.M., Villarreal, A.L., Farley, W., Li, D.Q., Stern, M.E., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  20. Facilitated wound healing by activation of the Transglutaminase 1 gene. Inada, R., Matsuki, M., Yamada, K., Morishima, Y., Shen, S.C., Kuramoto, N., Yasuno, H., Takahashi, K., Miyachi, Y., Yamanishi, K. Am. J. Pathol. (2000) [Pubmed]
  21. Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. Kömüves, L.G., Hanley, K., Lefebvre, A.M., Man, M.Q., Ng, D.C., Bikle, D.D., Williams, M.L., Elias, P.M., Auwerx, J., Feingold, K.R. J. Invest. Dermatol. (2000) [Pubmed]
  22. Plasminogen activator inhibitor 2: expression and role in differentiation of epidermal keratinocyte. Lian, X., Yang, T. Biol. Cell (2004) [Pubmed]
  23. Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia. Uyttendaele, H., Panteleyev, A.A., de Berker, D., Tobin, D.T., Christiano, A.M. Differentiation (2004) [Pubmed]
  24. Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero. Schmuth, M., Schoonjans, K., Yu, Q.C., Fluhr, J.W., Crumrine, D., Hachem, J.P., Lau, P., Auwerx, J., Elias, P.M., Feingold, K.R. J. Invest. Dermatol. (2002) [Pubmed]
  25. Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Candi, E., Rufini, A., Terrinoni, A., Dinsdale, D., Ranalli, M., Paradisi, A., De Laurenzi, V., Spagnoli, L.G., Catani, M.V., Ramadan, S., Knight, R.A., Melino, G. Cell Death Differ. (2006) [Pubmed]
  26. Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skin. Christensen, R., Alhonen, L., Wahlfors, J., Jakobsen, M., Jensen, T.G. Exp. Dermatol. (2005) [Pubmed]
  27. Id2 is dispensable for Myc-induced epidermal neoplasia. Murphy, D.J., Swigart, L.B., Israel, M.A., Evan, G.I. Mol. Cell. Biol. (2004) [Pubmed]
  28. Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme. Tsuji, T., Usui, S., Aida, T., Tachikawa, T., Hu, G.F., Sasaki, A., Matsumura, T., Todd, R., Wong, D.T. Oncogene (2001) [Pubmed]
  29. The ENaC channel is required for normal epidermal differentiation. Mauro, T., Guitard, M., Behne, M., Oda, Y., Crumrine, D., Komuves, L., Rassner, U., Elias, P.M., Hummler, E. J. Invest. Dermatol. (2002) [Pubmed]
  30. Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin. Kim, S., Hong, I., Hwang, J.S., Choi, J.K., Rho, H.S., Kim, D.H., Chang, I., Lee, S.H., Lee, M.O., Hwang, J.S. Mol. Med. (2006) [Pubmed]
  31. Cross-linked envelope-related markers for squamous differentiation in human lung cancer cell lines. Levitt, M.L., Gazdar, A.F., Oie, H.K., Schuller, H., Thacher, S.M. Cancer Res. (1990) [Pubmed]
  32. Changes in the abundance and distribution of actin and associated proteins during terminal differentiation of human epidermal keratinocytes. Kubler, M.D., Jordan, P.W., O'Neill, C.H., Watt, F.M. J. Cell. Sci. (1991) [Pubmed]
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