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Pou2f1  -  POU class 2 homeobox 1

Rattus norvegicus

Synonyms: NF-A1, OTF-1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, ...
 
 
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Disease relevance of Pou2f1

  • Our aim was to investigate the effects of obstructive cholestasis on Oct1 expression and function in liver and kidney [1].
  • A ubiquitous mammalian transcription factor, Oct-1 (also known as OTF-1, NF-A1, OBP100, or NFIII), stimulates the initiation of replication of adenovirus DNA, and may also be involved in the activation of some chromosomal replication origins [2].
 

High impact information on Pou2f1

 

Biological context of Pou2f1

 

Anatomical context of Pou2f1

  • Oct-1, a ubiquitous POU homeodomain transcription factor, was identified as an essential factor regulating GnRH transcription in the GT1-7 hypothalamic neuronal cell line [3].
  • The RNA encoding the octamer-binding transcription factor Oct-2 is alternatively spliced in both neuronal cells and in B cells to yield multiple mRNAs encoding different isoforms of the protein [7].
 

Associations of Pou2f1 with chemical compounds

  • Neither Oct1 nor NF-kappa B binding activities were blocked by CHX, suggesting that other factor(s) synthesized in response to IL-1 beta contribute to iNOS promoter induction [4].
  • Bioactivation of the formamide N-formylamphetamine (NFA) to 1-methyl-2-phenylethyl isocyanate (MPIC) was investigated in rats by screening bile and urine for conjugates subsequent to the phase I event [8].
 

Analytical, diagnostic and therapeutic context of Pou2f1

  • NFA was administered to rats as a mixture of protio- and pentadeuteriophenyl analogues to gain insight into the carbamoylating activity of MPIC when traced by electrospray liquid chromatography/mass spectrometry (LC/MS) [8].
  • OTF1 and OTF6 also showed significant inhibition of caries induction, with the minimum inhibitory concentration of OTF6 being 50 microg/ml in drinking water and the minimum inhibitory concentration of OTF1 being 100 microg/g in diet [9].

References

  1. Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. Denk, G.U., Soroka, C.J., Mennone, A., Koepsell, H., Beuers, U., Boyer, J.L. Hepatology (2004) [Pubmed]
  2. Rat DNA sequence associated with a complex form of DNA polymerase alpha in nonregenerating liver interacts with a ubiquitous transcription/replication factor Oct-1. Timchenko, N.A., Zhuchenko, O.P., Timchenko, L.T., Iguchi-Ariga, S.M., Ariga, H., Bozhkov, V.M., Tomilin, N.V. Biomed. Sci. (1991) [Pubmed]
  3. TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. Rave-Harel, N., Givens, M.L., Nelson, S.B., Duong, H.A., Coss, D., Clark, M.E., Hall, S.B., Kamps, M.P., Mellon, P.L. J. Biol. Chem. (2004) [Pubmed]
  4. An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells. Darville, M.I., Terryn, S., Eizirik, D.L. Endocrinology (2004) [Pubmed]
  5. Proteins interacting with an androgen-responsive unit in the C3(1) gene intron. Celis, L., Claessens, F., Peeters, B., Heyns, W., Verhoeven, G., Rombauts, W. Mol. Cell. Endocrinol. (1993) [Pubmed]
  6. Investigation of possible involvement of several genes related to development of hepatocarcinogenesis in rats. Todaka, N., Higashi, K., Yan, Y., Abe, T., Yamashiro, K., Hiai, H. J. UOEH (2000) [Pubmed]
  7. Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters. Lillycrop, K.A., Latchman, D.S. J. Biol. Chem. (1992) [Pubmed]
  8. Characterization of novel isocyanate-derived metabolites of the formamide N-formylamphetamine with the combined use of electrospray mass spectrometry and stable isotope methodology. Borel, A.G., Abbott, F.S. Chem. Res. Toxicol. (1995) [Pubmed]
  9. Comparison of the cariostatic effects between regimens to administer oolong tea polyphenols in SPF rats. Ooshima, T., Minami, T., Matsumoto, M., Fujiwara, T., Sobue, S., Hamada, S. Caries Res. (1998) [Pubmed]
 
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