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Gene Review

Pou2f1  -  POU domain, class 2, transcription factor 1

Mus musculus

Synonyms: 2810482H01Rik, NF-A1, OTF-1, Oct-1, Oct-1A, ...
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Disease relevance of Pou2f1

  • We report the cDNA cloning of the human oct-1 gene, which encodes Oct-1, by screening lambda gt11 recombinant phage in situ for octamer motif-specific DNA binding [1].
  • Herpes simplex virus infections are arrested in Oct-1-deficient cells [2].
  • Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter [3].
  • The plasma concentration of metformin exhibited similar time profiles between the wild-type and Oct1(-/-) mice, suggesting that the liver is the key organ responsible for the lactic acidosis [4].

High impact information on Pou2f1


Biological context of Pou2f1


Anatomical context of Pou2f1


Associations of Pou2f1 with chemical compounds

  • Oct3 is an embryonic octamer-binding transcription factor, whose expression is rapidly repressed by retinoic acid (RA) [14].
  • Consistent with this finding, Oct-1-deficient fibroblasts were hypersensitive to gamma radiation, doxorubicin, and hydrogen peroxide and harbored elevated reactive oxygen species [15].
  • Finally, experiments designed to exploit the sensitivity of discrete steps in transcription complex assembly to the anionic detergent Sarkosyl demonstrated that Oct-1 must be present during formation of an early intermediate in the assembly process [3].
  • When mice were given metformin, the blood lactate concentration significantly increased in the wild-type mice, whereas only a slight increase was observed in Oct1(-/-) mice [4].
  • Whereas one clone (oct-1a) was very similar to its human oct-1 homologue, the other (oct-1b), contained an additional 72 bp sequence (designated E1) at the serine threonine rich coding region (position 1485 of the human oct-1), and a deletion of another 72 bp sequence (designated E2) downstream (position 1920) [16].

Physical interactions of Pou2f1


Regulatory relationships of Pou2f1

  • Our results demonstrate that in these Oct2-deficient B cells the ubiquitous endogenous Oct1 protein is able to stimulate octamer-containing promoters to a level comparable with that of normal Oct2-positive B cells [19].

Other interactions of Pou2f1

  • The mRNAs of two additional POU genes, Emb (POU class VI) and Oct-1 (POU class II), were also expressed in developing muscle and, unlike Brn-4, continued to be expressed in postnatal and adult muscles [20].
  • Oct-1, silencer sequence, and GC box regulate thyroid hormone receptor beta1 promoter [21].
  • Mutation of the silencer response element, mutation of the GC box, and Oct-1 over expression in COS 1 cells increased TR beta1 promoter function as assayed by Luciferase reporter [21].
  • The proteins, which were not recognized by an anti-Oct-1 antibody, may be involved in regulation of the initiation of DNA replication in the IgH gene [22].
  • To study the role of Oct-1 in these processes, the lymphoid compartment of RAG-1(-/-) animals was reconstituted with Oct-1-deficient fetal liver hematopoietic cells [23].

Analytical, diagnostic and therapeutic context of Pou2f1


  1. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Sturm, R.A., Das, G., Herr, W. Genes Dev. (1988) [Pubmed]
  2. Herpes simplex virus infections are arrested in Oct-1-deficient cells. Nogueira, M.L., Wang, V.E., Tantin, D., Sharp, P.A., Kristie, T.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter. Kim, M.H., Peterson, D.O. J. Biol. Chem. (1995) [Pubmed]
  4. Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Wang, D.S., Kusuhara, H., Kato, Y., Jonker, J.W., Schinkel, A.H., Sugiyama, Y. Mol. Pharmacol. (2003) [Pubmed]
  5. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Okamoto, K., Okazawa, H., Okuda, A., Sakai, M., Muramatsu, M., Hamada, H. Cell (1990) [Pubmed]
  6. A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Staudt, L.M., Singh, H., Sen, R., Wirth, T., Sharp, P.A., Baltimore, D. Nature (1986) [Pubmed]
  7. Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand. Ohno, H., Goto, S., Taki, S., Shirasawa, T., Nakano, H., Miyatake, S., Aoe, T., Ishida, Y., Maeda, H., Shirai, T. EMBO J. (1994) [Pubmed]
  8. The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Clark, M.E., Mellon, P.L. Mol. Cell. Biol. (1995) [Pubmed]
  9. A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300. Molinari, S., Relaix, F., Lemonnier, M., Kirschbaum, B., Schäfer, B., Buckingham, M. Mol. Cell. Biol. (2004) [Pubmed]
  10. The glucocorticoid receptor is tethered to DNA-bound Oct-1 at the mouse gonadotropin-releasing hormone distal negative glucocorticoid response element. Chandran, U.R., Warren, B.S., Baumann, C.T., Hager, G.L., DeFranco, D.B. J. Biol. Chem. (1999) [Pubmed]
  11. Chromosomal location of the octamer transcription factors, Otf-1, Otf-2, and Otf-3, defines multiple Otf-3-related sequences dispersed in the mouse genome. Siracusa, L.D., Rosner, M.H., Vigano, M.A., Gilbert, D.J., Staudt, L.M., Copeland, N.G., Jenkins, N.A. Genomics (1991) [Pubmed]
  12. Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1. Shore, P., Dietrich, W., Corcoran, L.M. Nucleic Acids Res. (2002) [Pubmed]
  13. Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Wang, V.E., Schmidt, T., Chen, J., Sharp, P.A., Tantin, D. Mol. Cell. Biol. (2004) [Pubmed]
  14. The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. Okazawa, H., Okamoto, K., Ishino, F., Ishino-Kaneko, T., Takeda, S., Toyoda, Y., Muramatsu, M., Hamada, H. EMBO J. (1991) [Pubmed]
  15. The octamer binding transcription factor Oct-1 is a stress sensor. Tantin, D., Schild-Poulter, C., Wang, V., Haché, R.J., Sharp, P.A. Cancer Res. (2005) [Pubmed]
  16. Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor. Jaffe, J., Hochberg, M., Riss, J., Hasin, T., Reich, L., Laskov, R. Biochim. Biophys. Acta (1995) [Pubmed]
  17. Structure and expression of the mouse Oct2a and Oct2b, two differentially spliced products of the same gene. Hatzopoulos, A.K., Stoykova, A.S., Erselius, J.R., Goulding, M., Neuman, T., Gruss, P. Development (1990) [Pubmed]
  18. Interplay of steroid hormone receptors and transcription factors on the mouse mammary tumor virus promoter. Truss, M., Chalepakis, G., Beato, M. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]
  19. Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities. Pfisterer, P., Annweiler, A., Ullmer, C., Corcoran, L.M., Wirth, T. EMBO J. (1994) [Pubmed]
  20. POU homeodomain genes and myogenesis. Dominov, J.A., Miller, J.B. Dev. Genet. (1996) [Pubmed]
  21. Oct-1, silencer sequence, and GC box regulate thyroid hormone receptor beta1 promoter. Nagasawa, T., Takeda, T., Minemura, K., DeGroot, L.J. Mol. Cell. Endocrinol. (1997) [Pubmed]
  22. Identification of novel single-stranded DNA binding proteins recognizing octamer motif. Ogawa, N., Ariga, H., Iguchi-Ariga, S.M. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  23. B cell development and immunoglobulin transcription in Oct-1-deficient mice. Wang, V.E., Tantin, D., Chen, J., Sharp, P.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  24. Oct-1 promoter region contains octamer sites and TAAT motifs recognized by Oct proteins. Pankratova, E.V., Polanovsky, O.L., Polanovasky, O.L. FEBS Lett. (1998) [Pubmed]
  25. Decreasing effect of an anti-Nfa1 polyclonal antibody on the in vitro cytotoxicity of pathogenic Naegleria fowleri. Jeong, S.R., Kang, S.Y., Lee, S.C., Song, K.J., Im, K.I., Shin, H.J. Korean J. Parasitol. (2004) [Pubmed]
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