Gene Review:
ECT2 - epithelial cell transforming 2
Homo sapiens
Synonyms:
ARHGEF31, Epithelial cell-transforming sequence 2 oncogene, Protein ECT2
- Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients. Sano, M., Genkai, N., Yajima, N., Tsuchiya, N., Homma, J., Tanaka, R., Miki, T., Yamanaka, R. Oncol. Rep. (2006)
- An ECT2-centralspindlin complex regulates the localization and function of RhoA. Yüce, O., Piekny, A., Glotzer, M. J. Cell Biol. (2005)
- Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. Oceguera-Yanez, F., Kimura, K., Yasuda, S., Higashida, C., Kitamura, T., Hiraoka, Y., Haraguchi, T., Narumiya, S. J. Cell Biol. (2005)
- Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I., Miki, T. J. Cell Biol. (1999)
- MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Zhao, W.M., Fang, G. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. Niiya, F., Xie, X., Lee, K.S., Inoue, H., Miki, T. J. Biol. Chem. (2005)
- Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. Niiya, F., Tatsumoto, T., Lee, K.S., Miki, T. Oncogene (2006)
- Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains. Saito, S., Tatsumoto, T., Lorenzi, M.V., Chedid, M., Kapoor, V., Sakata, H., Rubin, J., Miki, T. J. Cell. Biochem. (2003)
- The epithelial cell transforming sequence 2, a guanine nucleotide exchange factor for Rho GTPases, is repressed by p53 via protein methyltransferases and is required for G1-S transition. Scoumanne, A., Chen, X. Cancer Res. (2006)
- Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. Nishimura, Y., Yonemura, S. J. Cell. Sci. (2006)
- Cell type-specific regulation of RhoA activity during cytokinesis. Yoshizaki, H., Ohba, Y., Parrini, M.C., Dulyaninova, N.G., Bresnick, A.R., Mochizuki, N., Matsuda, M. J. Biol. Chem. (2004)
- Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase. Hara, T., Abe, M., Inoue, H., Yu, L.R., Veenstra, T.D., Kang, Y.H., Lee, K.S., Miki, T. Oncogene (2006)
- Chromosomal localization of the human ECT2 proto-oncogene to 3q26.1-->q26.2 by somatic cell analysis and fluorescence in situ hybridization. Takai, S., Long, J.E., Yamada, K., Miki, T. Genomics (1995)