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SPAG17  -  sperm associated antigen 17

Homo sapiens

Synonyms: CT143, FLJ34497, PF6, Projection protein PF6 homolog, RP4-776P7.2, ...
 
 
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High impact information on SPAG17

  • The Chlamydomonas PF6 locus encodes a large alanine/proline-rich polypeptide that is required for assembly of a central pair projection and regulates flagellar motility [1].
  • Sequence analysis indicates that the PF6 gene encodes a large polypeptide that contains numerous alanine-rich, proline-rich, and basic domains and has limited homology to an expressed sequence tag derived from a human testis cDNA library [1].
  • In this article we explore in atomistic detail and explain in an intuitive way the peculiar volumetric behavior experimentally observed when supercritical CO2 is dissolved in 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim+] [PF6(-)]) [2].
  • Why is the partial molar volume of CO2 so small when dissolved in a room temperature ionic liquid? Structure and dynamics of CO2 dissolved in [Bmim+] [PF6(-)] [2].
  • TpRu(PPh3)(CH3CN)2 PF6 (10 mol %) catalyst effected the nucleophilic addition of water, alcohols, aniline, acetylacetone, pyrroles, and dimethyl malonate to unfunctionalized enediynes under suitable conditions (100 degrees C, 12-24 h) and gave functionalized benzene products in good yields [3].
 

Biological context of SPAG17

  • We report structure-activity relationships for organometallic RuII complexes of the type [(eta6-arene)Ru(XY)Cl]Z, where XY is an N,N- (diamine), N,O- (e.g., amino acidate), or O,O- (e.g., beta-diketonate) chelating ligand, the arene ranges from benzene derivatives to fused polycyclic hydrocarbons, and Z is usually PF6 [4].
  • The structure of ([W3Q4X3(dmpe)3]+, Y-) ion pairs (Q = S, Se; X = H, OH, Br; Y = BF4, PF6, dmpe = Me2PCH2CH2PMe2) in dichloromethane solution and the effect of ion-pairing on the kinetics of proton transfer to the hydride cluster [W3S4H3(dmpe)3]+ [5].
  • Single crystal X-ray structures of L1 and [RuII(bipy)2(L2H)](H2PO4)3.(CH3)2CO.0.8H2O were obtained, the latter revealing the presence of H2PO4- counter anions, the source of which is presumed to be hydrolysis of PF6- ions [6].
  • Complexes of the type [Re(III)L6]X3, with L = thiourea, N-methylthiourea, N-ethylthiourea or N,N'-dimethytlthiourea and X = Cl- or PF6-, were prepared as suitable precursors for the synthesis of new rhenium complexes potentially useful in nuclear medicine [7].
 

Anatomical context of SPAG17

  • The murine Pf6 gene is expressed in a pattern consistent with a role in flagella and cilia, and the PF6 protein is indeed localized to the central apparatus of the sperm flagellar axoneme [8].
  • PF6, a component of the Chlamydomonas central apparatus, is localized to the 1a projection of the C1 microtubule [8].
 

Associations of SPAG17 with chemical compounds

  • Carrier dynamics in conducting polymers: case of PF6 doped polypyrrole [9].
  • Changing the counteranion along the series Br, BF4, PF6, SbF6 in their ion-paired 2-pyridylmethyl imidazolium salts causes the kinetic reaction products with IrH5(PPh3)2 to switch from chelating N-heterocyclic carbenes (NHCs) having normal C2 (N path) to abnormal C5 binding (AN path) [10].
  • The conductance sequence for anion efflux was NO3 greater than SCN approximately ClO4 greater than Cl approximately I approximately Br greater than PF6 greater than F approximately HCO3 much greater than H2PO4 [11].
  • The permeability sequence was SCN greater than I approximately NO3 approximately ClO4 greater than Br greater than Cl greater than PF6 greater than HCO3 approximately F much greater than H2PO4 [11].
  • The quenching rate constants of the visible emission of [Au2(dcpm)2]2+ in acetonitrile by various anions are 6.08 x 10(5) (ClO4-), 9.18 x l0(5) (PF6 ), 1.55 x 10(7) (Cl-) and 4.06 x 10(9) (I-) mol(-1) dm3s(-1) [12].
 

Physical interactions of SPAG17

 

Analytical, diagnostic and therapeutic context of SPAG17

  • The absorption bands of [Cu2(dcpm)2]X2 and [Cu2(dcpm)2(CH3CN)2]X2 (X=ClO4- and PF6-) at lambda max 307-311 nm in CH2Cl2 are assigned as 1[3d sigma* --> 4p sigma] transitions; this has been confirmed by resonance Raman spectroscopy [13].
  • The structural features of the bis-betaines 1, betaines 2 x PF6 and 5 x X, and the corresponding dicationic [1(4)]heterophanes 3 x 2X and 4 x 2Cl were studied by 1H and 13C NMR spectroscopy and electrospray ionization mass spectrometry, and confirmed by single-crystal X-ray diffraction analysis of macrocycles 1a and 2a x PF6 [14].
  • The order of increasing ease of crystallization of the cluster salts was I- > PF6- approximately ClO4- > BF4- >> NO3-. The cluster structure is retained in alcohol and acetonitrile solutions; the UV-vis spectra of the solutions are perfectly consistent with the powder diffuse reflection spectrum [15].
  • HPLC retention of perchlorate (ClO4-), tetrafluoroborate (BF4-), and hexafluorophosphate (PF6-) ions was studied on six columns with different bonded phases including alkyl, phenyl and perfluorophenyl phases [16].

References

  1. The Chlamydomonas PF6 locus encodes a large alanine/proline-rich polypeptide that is required for assembly of a central pair projection and regulates flagellar motility. Rupp, G., O'Toole, E., Porter, M.E. Mol. Biol. Cell (2001) [Pubmed]
  2. Why is the partial molar volume of CO2 so small when dissolved in a room temperature ionic liquid? Structure and dynamics of CO2 dissolved in [Bmim+] [PF6(-)]. Huang, X., Margulis, C.J., Li, Y., Berne, B.J. J. Am. Chem. Soc. (2005) [Pubmed]
  3. Ruthenium-catalyzed aromatization of enediynes via highly regioselective nucleophilic additions on a pi-alkyne functionality. A useful method for the synthesis of functionalized benzene derivatives. Odedra, A., Wu, C.J., Pratap, T.B., Huang, C.W., Ran, Y.F., Liu, R.S. J. Am. Chem. Soc. (2005) [Pubmed]
  4. Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. Habtemariam, A., Melchart, M., Fernandez, R., Parsons, S., Oswald, I.D., Parkin, A., Fabbiani, F.P., Davidson, J.E., Dawson, A., Aird, R.E., Jodrell, D.I., Sadler, P.J. J. Med. Chem. (2006) [Pubmed]
  5. The structure of ([W3Q4X3(dmpe)3]+, Y-) ion pairs (Q = S, Se; X = H, OH, Br; Y = BF4, PF6, dmpe = Me2PCH2CH2PMe2) in dichloromethane solution and the effect of ion-pairing on the kinetics of proton transfer to the hydride cluster [W3S4H3(dmpe)3]+. Algarra, A.G., Basallote, M.G., Fernandez-Trujillo, M.J., Llusar, R., Safont, V.S., Vicent, C. Inorganic chemistry. (2006) [Pubmed]
  6. Metal-to-ligand charge-transfer sensitisation of near-infrared emitting lanthanides in trimetallic arrays M2Ln (M=Ru, Re or Os; Ln=Nd, Er or Yb). Pope, S.J., Coe, B.J., Faulkner, S., Laye, R.H. Dalton transactions (Cambridge, England : 2003) (2005) [Pubmed]
  7. Infrared spectra of new Re(III) complexes with thiourea derivatives. Gambino, D., Kremer, E., Baran, E.J. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2002) [Pubmed]
  8. Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16. Zhang, Z., Jones, B.H., Tang, W., Moss, S.B., Wei, Z., Ho, C., Pollack, M., Horowitz, E., Bennett, J., Baker, M.E., Strauss, J.F. Mol. Cell Proteomics (2005) [Pubmed]
  9. Carrier dynamics in conducting polymers: case of PF6 doped polypyrrole. Romijn, I.G., Hupkes, H.J., Martens, H.C., Brom, H.B., Mukherjee, A.K., Menon, R. Phys. Rev. Lett. (2003) [Pubmed]
  10. An anion-dependent switch in selectivity results from a change of C-H activation mechanism in the reaction of an imidazolium salt with IrH5(PPh3)2. Appelhans, L.N., Zuccaccia, D., Kovacevic, A., Chianese, A.R., Miecznikowski, J.R., Macchioni, A., Clot, E., Eisenstein, O., Crabtree, R.H. J. Am. Chem. Soc. (2005) [Pubmed]
  11. Anion permeation in an apical membrane chloride channel of a secretory epithelial cell. Halm, D.R., Frizzell, R.A. J. Gen. Physiol. (1992) [Pubmed]
  12. Substrate-Binding reactions of the 3[dsigma*psigma] excited state of binuclear gold(I) complexes with bridging bis(dicyclohexylphosphino)methane ligands: emission and time-resolved absorption spectroscopic studies. Fu, W.F., Chan, K.C., Cheung, K.K., Che, C.M. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
  13. 3[(dx2-y2,dxy)(pz)] excited state of binuclear copper(I) phosphine complexes: effect of copper-ligand and copper-copper interactions on excited state properties and photocatalytic reductions of the 4,4'-dimethyl-2,2'-bipyridinium ion in alcohols. Mao, Z.M., Chao, H.Y., Che, C.M., Fu, W.F., Cheung, K.K., Zhu, N. Chemistry (Weinheim an der Bergstrasse, Germany) (2003) [Pubmed]
  14. Novel bis-betaines and betaines within [1(4)]meta-heterophane frameworks. Alcalde, E., Mesquida, N., Pérez-García, L., Ramos, S., Alemany, M., Rodríguez, M.L. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  15. Synthesis of stable crystals of a self-assembled centered icosahedral samarium cluster formed by bis(L-prolinato)nickel(II) ligands. Igarashi, S., Hoshino, Y., Masuda, Y., Yukawa, Y. Inorganic chemistry. (2000) [Pubmed]
  16. Reversed-phase high-performance liquid chromatography behavior of chaotropic counteranions. Kazakevich, Y.V., LoBrutto, R., Vivilecchia, R. Journal of chromatography. A. (2005) [Pubmed]
 
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