Psychiatry related information on tf

• Neonatal sensory deprivation reduces tufted cell number in mouse olfactory bulbs [1].

High impact information on tf

• Genetic data support this idea, in that the tufted gene, the H-2 complex and a group of H-2-related genes appear to be in inverted order in t haplotypes relative to the standard chromosome 17 [2].
• To test the structural stability of adult dendrites in this context, we used two-photon microscopy to image dendrites of mitral and tufted (M/T) cells over prolonged periods in adult mice [3].
• The anaxonic granule cell of the olfactory bulb is believed to inhibit mitral and tufted cells through reciprocal dendrodendritic synapses [4].
• Backcross progeny, (NC X TF/GnLe)F1 X TF/GnLe, was tested for C3 allotype controlled by C3-1 and the expression of mutant gene tf, repeated loss and regrowth of hair [5].
• A classical breeding analysis of the complete t haplotypes, tw5 and t12, utilizing the newly induced markers, reveals two inversions in t chromatin: one involving T and qk, and one involving tf and the H-2 complex [6].

Biological context of tf

• Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted) [7].
• The results presented here allow a mapping of the Tme locus between the quaking and tufted loci which are 3 cM apart within the proximal region of chromosome 17 [8].
• The genetics of the fused (Fu) gene in the house mouse, Mus musculus, was studied by use of the closely linked recessive marker, tufted (tf) [9].
• In addition to t-int, new mutations at the quaking and tufted loci were obtained, as well as at several loci not on chromosome 17, e.g., an X-linked lethal that causes a mottled phenotype in the heterozygote and four new mutant W alleles on chromosome 5 [10].
• High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci [11].

Anatomical context of tf

• The two subsets of sensory neurons project their axons to segregated zones of the accessory olfactory bulb (AOB) and connect with zonally separated mitral/tufted (M/T) cells, suggesting that the accessory olfactory system is divided into two distinct pathways up to the level of the AOB [12].
• In the main olfactory bulb (MOB), infection was observed in periglomerular, tufted, and mitral cells and in interneurons located in the internal plexiform layer [13].
• In extraglomerular regions, the mitral/tufted cell somata, dendrites and axon hillocks made gap junctions and mixed synapses with interneuronal processes [14].
• Biocytin-filling confirmed that the recorded cells included interneurons, tufted cells, and astrocytes [15].
• In the external plexiform layer (EPL) of the main olfactory bulb, apical dendrites of inhibitory granule cells form large numbers of synapses with mitral and tufted (M/T) cells, which regulate the spread of activity along the M/T cell dendrites [15].

Associations of tf with chemical compounds

• Mutations induced by N-ethyl-N-nitrosourea (ENU) at the Brachyury (T), quaking (qk), and tufted (tf) loci of the mouse tw5 haplotype have now allowed the analysis of crossovers between two complete t haplotypes [6].
• By sensitizing C3H.Ttf (C3H.Brachyury, tufted) with the congenic strain C3H.Ttf/tw18 splenic cells, a response against lipopolysaccharide (LPS) stimulated splenic cells from C3H.Ttf/tw18 mice is obtained [16].
• Taken together, these results suggest that DHEAS potentiates the GABAergic dendrodendritic inhibition exerted by the granule cells on the mitral/tufted cells [17].
• The time course of the transporter currents suggested that rapid synchronous glutamate release at OSN terminals triggers asynchronous glutamate release from mitral/tufted cells [18].
• The astrocyte K+ current was dependent on AMPA and NMDA receptors in mitral/tufted cells as well as on a previously undescribed metabotropic glutamate receptor 1 component [18].

Physical interactions of tf

• The most straightforward interpretation of the results presented here is that these t haplotypes carry an H-2 complex located between the centromere and tufted locus [19].

Other interactions of tf

• Thus both chemical synapses and gap junctions interconnect complexly various processes in the glomerulus, where the local circuit among intermingled olfactory nerves, mitral/tufted cell dendrites and interneuron dendrites is far more complex than previously schematized [20].
• DA and D2 receptor agonists reduced ON-evoked synaptic responses in mitral/tufted and juxtaglomerular cells [21].
• In the olfactory bulbs of the transgenic mice, connexin 36 was expressed in mitral cells, tufted cells, presumed granule cells and periglomerular cells [14].

Analytical, diagnostic and therapeutic context of tf

• Southern blot analysis of DNA from T-tf recombinants with a separation of tw12 and tf indicated that tw12 is proximal to tf [7].
• This indicates that many granule cell spines survive denervation and establish new reciprocal dendrodendritic synapses at available sites on tufted cells [22].
• The size of asymmetrical excitatory synapses (mitral/tufted to granule cells) of the reciprocal synapses was significantly larger in the group of female mice which were subjected to a treatment intended to induce olfactory memory formation than in the control group [23].

References