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Gene Review

tf  -  tufted

Mus musculus

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Psychiatry related information on tf


High impact information on tf

  • Genetic data support this idea, in that the tufted gene, the H-2 complex and a group of H-2-related genes appear to be in inverted order in t haplotypes relative to the standard chromosome 17 [2].
  • To test the structural stability of adult dendrites in this context, we used two-photon microscopy to image dendrites of mitral and tufted (M/T) cells over prolonged periods in adult mice [3].
  • The anaxonic granule cell of the olfactory bulb is believed to inhibit mitral and tufted cells through reciprocal dendrodendritic synapses [4].
  • Backcross progeny, (NC X TF/GnLe)F1 X TF/GnLe, was tested for C3 allotype controlled by C3-1 and the expression of mutant gene tf, repeated loss and regrowth of hair [5].
  • A classical breeding analysis of the complete t haplotypes, tw5 and t12, utilizing the newly induced markers, reveals two inversions in t chromatin: one involving T and qk, and one involving tf and the H-2 complex [6].

Biological context of tf

  • Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted) [7].
  • The results presented here allow a mapping of the Tme locus between the quaking and tufted loci which are 3 cM apart within the proximal region of chromosome 17 [8].
  • The genetics of the fused (Fu) gene in the house mouse, Mus musculus, was studied by use of the closely linked recessive marker, tufted (tf) [9].
  • In addition to t-int, new mutations at the quaking and tufted loci were obtained, as well as at several loci not on chromosome 17, e.g., an X-linked lethal that causes a mottled phenotype in the heterozygote and four new mutant W alleles on chromosome 5 [10].
  • High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci [11].

Anatomical context of tf


Associations of tf with chemical compounds

  • Mutations induced by N-ethyl-N-nitrosourea (ENU) at the Brachyury (T), quaking (qk), and tufted (tf) loci of the mouse tw5 haplotype have now allowed the analysis of crossovers between two complete t haplotypes [6].
  • By sensitizing C3H.Ttf (C3H.Brachyury, tufted) with the congenic strain C3H.Ttf/tw18 splenic cells, a response against lipopolysaccharide (LPS) stimulated splenic cells from C3H.Ttf/tw18 mice is obtained [16].
  • Taken together, these results suggest that DHEAS potentiates the GABAergic dendrodendritic inhibition exerted by the granule cells on the mitral/tufted cells [17].
  • The time course of the transporter currents suggested that rapid synchronous glutamate release at OSN terminals triggers asynchronous glutamate release from mitral/tufted cells [18].
  • The astrocyte K+ current was dependent on AMPA and NMDA receptors in mitral/tufted cells as well as on a previously undescribed metabotropic glutamate receptor 1 component [18].

Physical interactions of tf

  • The most straightforward interpretation of the results presented here is that these t haplotypes carry an H-2 complex located between the centromere and tufted locus [19].

Other interactions of tf


Analytical, diagnostic and therapeutic context of tf

  • Southern blot analysis of DNA from T-tf recombinants with a separation of tw12 and tf indicated that tw12 is proximal to tf [7].
  • This indicates that many granule cell spines survive denervation and establish new reciprocal dendrodendritic synapses at available sites on tufted cells [22].
  • The size of asymmetrical excitatory synapses (mitral/tufted to granule cells) of the reciprocal synapses was significantly larger in the group of female mice which were subjected to a treatment intended to induce olfactory memory formation than in the control group [23].


  1. Neonatal sensory deprivation reduces tufted cell number in mouse olfactory bulbs. Skeen, L.C., Due, B.R., Douglas, F.E. Neurosci. Lett. (1986) [Pubmed]
  2. A major rearrangement in the H-2 complex of mouse t haplotypes. Rogers, J.H., Willison, K.R. Nature (1983) [Pubmed]
  3. Dendritic stability in the adult olfactory bulb. Mizrahi, A., Katz, L.C. Nat. Neurosci. (2003) [Pubmed]
  4. Local information processing in dendritic trees: subsets of spines in granule cells of the mammalian olfactory bulb. Woolf, T.B., Shepherd, G.M., Greer, C.A. J. Neurosci. (1991) [Pubmed]
  5. Genetic mapping of the locus controlling structural variations of murine C3 in the chromosome 17. Natsuume-Sakai, S., Hayakawa, J., Amano, S., Takahashi, M. J. Immunol. (1979) [Pubmed]
  6. Genetic analysis of mouse t haplotypes using mutations induced by ethylnitrosourea mutagenesis: the order of T and qk is inverted in t mutants. Justice, M.J., Bode, V.C. Genetics (1988) [Pubmed]
  7. Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted). Ark, B., Gummere, G., Bennett, D., Artzt, K. Genomics (1991) [Pubmed]
  8. Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect. Winking, H., Silver, L.M. Genetics (1984) [Pubmed]
  9. Inheritance of alternative states of the fused gene in mice. Belyaev, D.K., Ruvinsky, A.O., Borodin, P.M. J. Hered. (1981) [Pubmed]
  10. Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17. Bode, V.C. Genetics (1984) [Pubmed]
  11. High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci. Himmelbauer, H., Harvey, R.P., Copeland, N.G., Jenkins, N.A., Silver, L.M. Mamm. Genome (1994) [Pubmed]
  12. Convergence of segregated pheromonal pathways from the accessory olfactory bulb to the cortex in the mouse. von Campenhausen, H., Mori, K. Eur. J. Neurosci. (2000) [Pubmed]
  13. Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation. Lafay, F., Coulon, P., Astic, L., Saucier, D., Riche, D., Holley, A., Flamand, A. Virology (1991) [Pubmed]
  14. Neuronal gap junctions in the mouse main olfactory bulb: morphological analyses on transgenic mice. Kosaka, T., Deans, M.R., Paul, D.L., Kosaka, K. Neuroscience (2005) [Pubmed]
  15. Properties of external plexiform layer interneurons in mouse olfactory bulb slices. Hamilton, K.A., Heinbockel, T., Ennis, M., Szabó, G., Erdélyi, F., Hayar, A. Neuroscience (2005) [Pubmed]
  16. Detection of A t-complex antigen by secondary cell-mediated lymphocytotoxicity. Hammerberg, C. J. Immunogenet. (1982) [Pubmed]
  17. Neurosteroid modulation of dendrodendritic inhibition in the mouse olfactory bulb. Usui, M., Kawasaki, Y., Kaba, H. Neurosci. Lett. (1999) [Pubmed]
  18. Detecting activity in olfactory bulb glomeruli with astrocyte recording. De Saint Jan, D., Westbrook, G.L. J. Neurosci. (2005) [Pubmed]
  19. Recombination between two mouse t haplotypes (tw12tf and tLub-1): mapping of the H-2 complex relative to centromere and tufted (tf) locus. Pla, M., Condamine, H. Immunogenetics (1984) [Pubmed]
  20. Intraglomerular dendritic link connected by gap junctions and chemical synapses in the mouse main olfactory bulb: electron microscopic serial section analyses. Kosaka, T., Kosaka, K. Neuroscience (2005) [Pubmed]
  21. Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals. Ennis, M., Zhou, F.M., Ciombor, K.J., Aroniadou-Anderjaska, V., Hayar, A., Borrelli, E., Zimmer, L.A., Margolis, F., Shipley, M.T. J. Neurophysiol. (2001) [Pubmed]
  22. Plasticity of dendrodendritic microcircuits following mitral cell loss in the olfactory bulb of the murine mutant Purkinje cell degeneration. Greer, C.A., Halász, N. J. Comp. Neurol. (1987) [Pubmed]
  23. Synaptic plasticity in olfactory memory formation in female mice. Matsuoka, M., Kaba, H., Mori, Y., Ichikawa, M. Neuroreport (1997) [Pubmed]
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