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Gene Review

NINL  -  ninein-like

Homo sapiens

Synonyms: KIAA0980, NLP, Ninein-like protein, dJ691N24.1
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Disease relevance of RP4-691N24.1

  • Common and differential chemokine expression patterns in rs cells of NLP, EBV positive and negative classical Hodgkin lymphomas [1].
  • Eyes with retinal incarceration, compared to eyes without retinal incarceration, had an increased rate of NLP vision (63% vs. 15%; P < 0.01), persistent postsurgical hypotony (50% vs. 13%; P < 0.05), and irreparable retinal detachment (50% vs. 20%; P = 0.07) [2].
  • TARC, a CC chemokine, is frequently expressed in classic Hodgkin's lymphoma but not in NLP Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and most cases of anaplastic large cell lymphoma [3].
  • A definite trend toward an increased rate of NLP vision (P < 0.02), persistent hypotony (P < 0.05), and irreparable retinal detachment (P = 0.11) was observed with increasing suprachoroidal hemorrhage complexity [2].
  • Biological and clinical studies have shown that Hodgkin's disease (HD) can be divided into two major categories, termed nodular lymphocyte predominance HD (NLP HD) and classic HD (CHD) [4].

Psychiatry related information on RP4-691N24.1

  • Neuro Linguistic Programming or NLP as it is usually referred to is without doubt the most powerful communication model, to have emerged for use in management, during the last decade [5].

High impact information on RP4-691N24.1

  • NLP-induced cell death is an active, light-dependent process requiring HSP90 but not caspase activity, salicylic acid, jasmonic acid, ethylene, or functional SGT1a/SGT1b [6].
  • Our findings strongly suggest that NLP-induced necrosis requires interaction with a target site that is unique to the extracytoplasmic side of dicot plant plasma membranes [6].
  • In a separate multiple linear regression model, multiparous NLPP women who did not use multivitamin and mineral supplements had lower CD3+CD4+ cell percentages in the first month postpartum than did nulliparous control women [7].
  • Mean final visual acuity was 20/156 (median, 20/2500; range, 20/30 to NLP) [8].
  • RESULTS: Overall, 11 (23%) of 48 eyes had no light perception (NLP) vision develop, 9 (19%) of 48 eyes had persistent postsurgical hypotony (intraocular pressure < 6), and 21 (64%) of 33 eyes with retinal detachment enjoyed successful retinal reattachment surgery [2].

Chemical compound and disease context of RP4-691N24.1

  • Examination revealed no light perception (NLP) RE with axial proptosis and ocular motility restriction; fundal examination revealed a clinical picture of an ischaemic CRVO [9].

Biological context of RP4-691N24.1


Anatomical context of RP4-691N24.1

  • If true NLP vision is present, additional complicating factors should be suspected, particularly abnormalities of the choroidal circulation and the optic nerve [14].
  • From the data presented it is the feeling of the authors that cases with obstruction of the central retinal artery alone and NLP acuity in the involved eye are most unusual [14].
  • Light and electron-microscopic examination showed the characteristic lesions of the NLPP with sausage-like swelling of the myelin sheaths [15].
  • Antibody generated by immunization with BTAA and NLP can induce antibody-dependent cellular cytotoxicity (ADCC) and cytotoxic T cell (CTL) response towards BTAA-expressing MCF-7 cells [16].

Associations of RP4-691N24.1 with chemical compounds

  • Of the documented cases of massive intraocular gentamicin injection, two patients had no light perception (NLP) vision and one had bare light perception [17].

Analytical, diagnostic and therapeutic context of RP4-691N24.1

  • RESULTS: The incidence of no light perception (NLP) at 12 months after treatment for BAE was 35% [18].
  • CONCLUSIONS: Pre-operative and post-operative INV, post-operative macular ischemia, and post-operative VH appear to be risk factors for LP and NLP vision following diabetic vitrectomy, whereas overall improvements in surgical technique and visual outcome continue to be reported [19].
  • The UCLA Medical Imaging Informatics Group (MII) has developed a statistical NLP for the domain of radiology [20].
  • We have developed polymerase chain reaction (PCR) methods for the qualitative detection of the GM potatoes for the screening and the identification of NL, NLP and NLY [21].


  1. Common and differential chemokine expression patterns in rs cells of NLP, EBV positive and negative classical Hodgkin lymphomas. Maggio, E.M., Van Den Berg, A., Visser, L., Diepstra, A., Kluiver, J., Emmens, R., Poppema, S. Int. J. Cancer (2002) [Pubmed]
  2. Suprachoroidal hemorrhage: outcome of surgical management according to hemorrhage severity. Wirostko, W.J., Han, D.P., Mieler, W.F., Pulido, J.S., Connor, T.B., Kuhn, E. Ophthalmology (1998) [Pubmed]
  3. TARC, a CC chemokine, is frequently expressed in classic Hodgkin's lymphoma but not in NLP Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and most cases of anaplastic large cell lymphoma. Peh, S.C., Kim, L.H., Poppema, S. Am. J. Surg. Pathol. (2001) [Pubmed]
  4. Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin's disease. Carbone, A., Gloghini, A., Aldinucci, D., Gattei, V., Dalla-Favera, R., Gaidano, G. Br. J. Haematol. (2002) [Pubmed]
  5. Neuro linguistic programming--an aid to management. Boas, P. Australian health review : a publication of the Australian Hospital Association. (1983) [Pubmed]
  6. Phytotoxicity and innate immune responses induced by nep1-like proteins. Qutob, D., Kemmerling, B., Brunner, F., Küfner, I., Engelhardt, S., Gust, A.A., Luberacki, B., Seitz, H.U., Stahl, D., Rauhut, T., Glawischnig, E., Schween, G., Lacombe, B., Watanabe, N., Lam, E., Schlichting, R., Scheel, D., Nau, K., Dodt, G., Hubert, D., Gijzen, M., Nürnberger, T. Plant Cell (2006) [Pubmed]
  7. Postpartum maternal blood helper T (CD3+CD4+) and cytotoxic T (CD3+CD8+) cells: correlations with iron status, parity, supplement use, and lactation status. Zimmer, J.P., Garza, C., Heller, M.E., Butte, N., Goldman, A.S. Am. J. Clin. Nutr. (1998) [Pubmed]
  8. Diagnostic approaches to severe, atypical toxoplasmosis mimicking acute retinal necrosis. Moshfeghi, D.M., Dodds, E.M., Couto, C.A., Santos, C.I., Nicholson, D.H., Lowder, C.Y., Davis, J.L. Ophthalmology (2004) [Pubmed]
  9. Optic nerve toxoplasmosis and orbital inflammation as initial presentation of AIDS. Lee, M.W., Fong, K.S., Hsu, L.Y., Lim, W.K. Graefes Arch. Clin. Exp. Ophthalmol. (2006) [Pubmed]
  10. The progressive outer retinal necrosis syndrome. A variant of necrotizing herpetic retinopathy in patients with AIDS. Engstrom, R.E., Holland, G.N., Margolis, T.P., Muccioli, C., Lindley, J.I., Belfort, R., Holland, S.P., Johnston, W.H., Wolitz, R.A., Kreiger, A.E. Ophthalmology (1994) [Pubmed]
  11. Phenotype of three consanguineous Tunisian families with early-onset retinal degeneration caused by an R91W homozygous mutation in the RPE65 gene. El Matri, L., Ambresin, A., Schorderet, D.F., Kawasaki, A., Seeliger, M.W., Wenzel, A., Arsenijevic, Y., Borruat, F.X., Munier, F.L. Graefes Arch. Clin. Exp. Ophthalmol. (2006) [Pubmed]
  12. The relationship of late potentials to assessment of heart rate variability in post-infarction patients. Kao, T., Hsiao, H.C., Chiu, H.W., Kong, C.W. International journal of cardiology. (2000) [Pubmed]
  13. Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations. Poppema, S., Maggio, E., van den Berg, A. Leuk. Lymphoma (2004) [Pubmed]
  14. Central retinal artery obstruction and visual acuity. Brown, G.C., Magargal, L.E. Ophthalmology (1982) [Pubmed]
  15. Multiple exercise-related mononeuropathy with abdominal colic. Trockel, U., Schröder, J.M., Reiners, K.H., Toyka, K.V., Goerz, G., Freund, H.J. J. Neurol. Sci. (1983) [Pubmed]
  16. Neem leaf preparation enhances Th1 type immune response and anti-tumor immunity against breast tumor associated antigen. Mandal-Ghosh, I., Chattopadhyay, U., Baral, R. Cancer Immun. (2007) [Pubmed]
  17. Retinal toxicity secondary to intraocular gentamicin injection. McDonald, H.R., Schatz, H., Allen, A.W., Chenoweth, R.G., Cohen, H.B., Crawford, J.B., Klein, R., May, D.R., Snider, J.D. Ophthalmology (1986) [Pubmed]
  18. Bleb-associated endophthalmitis: clinical characteristics and visual outcomes. Busbee, B.G., Recchia, F.M., Kaiser, R., Nagra, P., Rosenblatt, B., Pearlman, R.B. Ophthalmology (2004) [Pubmed]
  19. Visual outcome and risk factors for light perception and no light perception vision after vitrectomy for diabetic retinopathy. Mason, J.O., Colagross, C.T., Haleman, T., Fuller, J.J., White, M.F., Feist, R.M., Emond, T.L., McGwin, G. Am. J. Ophthalmol. (2005) [Pubmed]
  20. A study of lexical behaviour of sentences in chest radiology reports. Bashyam, V., Taira, R.K. AMIA ... Annual Symposium proceedings [electronic resource] / AMIA Symposium. AMIA Symposium. (2005) [Pubmed]
  21. New qualitative detection methods of genetically modified potatoes. Watanabe, T., Kuribara, H., Mishima, T., Kikuchi, H., Kodama, T., Futo, S., Kasama, K., Toyota, A., Nouno, M., Saita, A., Takahashi, K., Hino, A., Akiyama, H., Maitani, T., Kubo, M. Biol. Pharm. Bull. (2004) [Pubmed]
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