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Gene Review

FYB  -  FYN binding protein

Homo sapiens

Synonyms: ADAP, Adhesion and degranulation promoting adaptor protein, FYB-120/130, FYN-T-binding protein, FYN-binding protein, ...
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Psychiatry related information on FYB


High impact information on FYB

  • The normal control and neurologic disease control cases had essentially no detectable level of ADAP, while ADAP was clearly detected in 85.7% of the Alzheimer's disease cases [1].
  • Recently the adapter protein ADAP/Fyb/Slap has been shown to couple TCR stimulation to integrin activation by mediating increased integrin avidity [2].
  • Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP [3].
  • Here, we show that upon activation of Jurkat cells microtubules project from the MTOC to a ring of the scaffolding protein ADAP, localized at the synapse [4].
  • ADAP coprecipitates with dynein from activated Jurkat cells, and loss of ADAP prevents MTOC translocation and the specific recruitment of dynein to the synapse [4].

Biological context of FYB


Anatomical context of FYB


Associations of FYB with chemical compounds

  • Recently ADAP was shown genetically to positively regulate T cell activation, TCR-induced integrin clustering, and T cell adhesion [12].
  • While primary binding occurs via SKAP-55 SH3 domain binding to a proline-rich region in ADAP, a second interaction occurs between the ADAP C-terminal SH3 domain (ADAP-SH3c) and a non-canonical RKXXY(294)XXY(297) motif in SKAP-55 [13].
  • ADAP levels in four regions of AD brains were not correlated to neuritic plaque count in corresponding regions of matching formaldehyde-fixed hemispheres [14].

Physical interactions of FYB

  • FYB/SLAP has the hallmarks of an adaptor protein that binds to the SH2 domains of the Src kinase FYN-T and SLP-76 [5].
  • Finally, we demonstrate that, as previously shown for SKAP55, SKAP-HOM interacts with the recently identified polypeptide SLAP-130 [15].

Regulatory relationships of FYB


Other interactions of FYB


Analytical, diagnostic and therapeutic context of FYB


  1. Biochemical assay of Alzheimer's disease--associated protein(s) in human brain tissue. A clinical study. Ghanbari, H.A., Miller, B.E., Haigler, H.J., Arato, M., Bissette, G., Davies, P., Nemeroff, C.B., Perry, E.K., Perry, R., Ravid, R. JAMA (1990) [Pubmed]
  2. Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Griffiths, E.K., Penninger, J.M. Curr. Opin. Immunol. (2002) [Pubmed]
  3. Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP. Kwon, J., Qu, C.K., Maeng, J.S., Falahati, R., Lee, C., Williams, M.S. EMBO J. (2005) [Pubmed]
  4. Recruitment of dynein to the Jurkat immunological synapse. Combs, J., Kim, S.J., Tan, S., Ligon, L.A., Holzbaur, E.L., Kuhn, J., Poenie, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production. Veale, M., Raab, M., Li, Z., da Silva, A.J., Kraeft, S.K., Weremowicz, S., Morton, C.C., Rudd, C.E. J. Biol. Chem. (1999) [Pubmed]
  6. Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain. Geng, L., Pfister, S., Kraeft, S.K., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  7. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. Musci, M.A., Hendricks-Taylor, L.R., Motto, D.G., Paskind, M., Kamens, J., Turck, C.W., Koretzky, G.A. J. Biol. Chem. (1997) [Pubmed]
  8. The Duffy protein: a malarial and chemokine receptor. Pogo, A.O., Chaudhuri, A. Semin. Hematol. (2000) [Pubmed]
  9. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. da Silva, A.J., Li, Z., de Vera, C., Canto, E., Findell, P., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. Marie-Cardine, A., Hendricks-Taylor, L.R., Boerth, N.J., Zhao, H., Schraven, B., Koretzky, G.A. J. Biol. Chem. (1998) [Pubmed]
  11. The helically extended SH3 domain of the T cell adaptor protein ADAP is a novel lipid interaction domain. Heuer, K., Arbuzova, A., Strauss, H., Kofler, M., Freund, C. J. Mol. Biol. (2005) [Pubmed]
  12. ADAP-ting TCR signaling to integrins. Griffiths, E.K., Penninger, J.M. Sci. STKE (2002) [Pubmed]
  13. Regulation and Function of SKAP-55 Non-canonical Motif Binding to the SH3c Domain of Adhesion and Degranulation-promoting Adaptor Protein. Duke-Cohan, J.S., Kang, H., Liu, H., Rudd, C.E. J. Biol. Chem. (2006) [Pubmed]
  14. Distribution of Alzheimer's disease-associated protein (ADAP) in 10 human brains. Miller, B.E., Whetsell, W.O., Chong, J.K., Ghanbari, H.A. The Journal of neuropsychiatry and clinical neurosciences. (1992) [Pubmed]
  15. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. Marie-Cardine, A., Verhagen, A.M., Eckerskorn, C., Schraven, B. FEBS Lett. (1998) [Pubmed]
  16. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Liu, J., Kang, H., Raab, M., da Silva, A.J., Kraeft, S.K., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  17. Functional association between SLAP-130 and SLP-76 in Jurkat T cells. Boerth, N.J., Judd, B.A., Koretzky, G.A. J. Biol. Chem. (2000) [Pubmed]
  18. Molecular classification of human endometrial cycle stages by transcriptional profiling. Ponnampalam, A.P., Weston, G.C., Trajstman, A.C., Susil, B., Rogers, P.A. Mol. Hum. Reprod. (2004) [Pubmed]
  19. Prenatal genotyping of the Duffy blood group system by allele-specific polymerase chain reaction. Hessner, M.J., Pircon, R.A., Johnson, S.T., Luhm, R.A. Prenat. Diagn. (1999) [Pubmed]
  20. Immunochemical characterization of a monoclonal antibody specific for Alzheimer's disease associated protein. Bodenteich, A., Mitchell, L.G., Merril, C.R., Miller, B.E., Ghanbari, H.A., Heegaard, N.H. J. Neuroimmunol. (1992) [Pubmed]
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