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Gene Review

Dbnl  -  drebrin-like

Mus musculus

Synonyms: ABP1, Abp1, Actin-binding protein 1, Drebrin-like protein, SH3 domain-containing protein 7, ...
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Disease relevance of Dbnl


Psychiatry related information on Dbnl


High impact information on Dbnl

  • By shadowing specimens dried onto mice sheets we have obtained clear images of actin crosslinked by spectrin, an actin-binding protein found in erythrocytes [5].
  • These effects are mediated by two newly identified p53 transcriptional targets, the actin-binding protein Coronin 1b and the GTPase Rab13, both of which associate with the cytoskeleton and regulate neurite outgrowth [6].
  • Structural properties, biochemical analysis of its interaction partners and siRNA studies implicated mAbp1 as an accessory protein in clathrin-mediated endocytosis (CME) [7].
  • Here, we describe the generation and characterization of mice deficient for SH3P7/mAbp1 owing to targeted gene disruption in embryonic stem cells [7].
  • SH3P7/mAbp1 deficiency leads to tissue and behavioral abnormalities and impaired vesicle transport [7].

Biological context of Dbnl


Anatomical context of Dbnl


Associations of Dbnl with chemical compounds

  • We have identified a gene encoding a mouse homologue of Abp1p, and it is identical to SH3P7, a protein shown recently to be a target of Src tyrosine kinases [13].
  • We previously demonstrated that doxorubicin treatment of mice resulted in a selective decrease in expression of the Nd1 gene, which encoded a new kelch family actin binding protein in the heart [17].
  • The inhibitory effect of a dynamin proline-rich domain deletion mutant on the recruitment of Abp1 to the plasma membrane, coimmunoprecipitation of dynamin with Abp1, and coprecipitation of Abp1 with GST fusion of the dyanmin proline-rich domain demonstrate the interaction of Abp1 with dynamin 2 [18].

Physical interactions of Dbnl

  • We show that mAbp1 binds the Fyb N-terminal via its C-terminally located src homology 3 domain [1].

Other interactions of Dbnl


Analytical, diagnostic and therapeutic context of Dbnl


  1. Fyn binding protein, Fyb, interacts with mammalian actin binding protein, mAbp1. Yuan, M., Mogemark, L., Fällman, M. FEBS Lett. (2005) [Pubmed]
  2. Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein. Lin, J., Liu, J., Wang, Y., Zhu, J., Zhou, K., Smith, N., Zhan, X. Oncogene (2005) [Pubmed]
  3. Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy. Matsudo, Y., Takamori, Y., Fujimura, L., Nishio, S., Sasagawa, K., Komuro, I., Tokuhisa, T., Hatano, M. Transgenic Res. (2006) [Pubmed]
  4. Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Butkevich, E., Hülsmann, S., Wenzel, D., Shirao, T., Duden, R., Majoul, I. Curr. Biol. (2004) [Pubmed]
  5. Spectrin-actin associations studied by electron microscopy of shadowed preparations. Cohen, C.M., Tyler, J.M., Branton, D. Cell (1980) [Pubmed]
  6. The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. Di Giovanni, S., Knights, C.D., Rao, M., Yakovlev, A., Beers, J., Catania, J., Avantaggiati, M.L., Faden, A.I. EMBO J. (2006) [Pubmed]
  7. SH3P7/mAbp1 deficiency leads to tissue and behavioral abnormalities and impaired vesicle transport. Connert, S., Wienand, S., Thiel, C., Krikunova, M., Glyvuk, N., Tsytsyura, Y., Hilfiker-Kleiner, D., Bartsch, J.W., Klingauf, J., Wienands, J. EMBO J. (2006) [Pubmed]
  8. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Du, Y., Weed, S.A., Xiong, W.C., Marshall, T.D., Parsons, J.T. Mol. Cell. Biol. (1998) [Pubmed]
  9. Effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma. Yanagisawa, Y., Sato, Y., Asahi-Ozaki, Y., Ito, E., Honma, R., Imai, J., Kanno, T., Kano, M., Akiyama, H., Sata, T., Shinkai-Ouchi, F., Yamakawa, Y., Watanabe, S., Katano, H. J. Pathol. (2006) [Pubmed]
  10. Dynamics of the actin-binding protein drebrin in motile cells and definition of a juxtanuclear drebrin-enriched zone. Peitsch, W.K., Bulkescher, J., Spring, H., Hofmann, I., Goerdt, S., Franke, W.W. Exp. Cell Res. (2006) [Pubmed]
  11. Molecular cloning and dendritic localization of rat SH3P7. Yamazaki, H., Takahashi, H., Aoki, T., Shirao, T. Eur. J. Neurosci. (2001) [Pubmed]
  12. Neurite formation induced in neuroblastoma cells and genetically altered non-neuronal cells. Inoue, H.K., Shirao, T. Journal of electron microscopy. (1997) [Pubmed]
  13. Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation. Kessels, M.M., Engqvist-Goldstein, A.E., Drubin, D.G. Mol. Biol. Cell (2000) [Pubmed]
  14. Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. Le Bras, S., Foucault, I., Foussat, A., Brignone, C., Acuto, O., Deckert, M. J. Biol. Chem. (2004) [Pubmed]
  15. Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles. Kaksonen, M., Peng, H.B., Rauvala, H. J. Cell. Sci. (2000) [Pubmed]
  16. EGF receptor activity is essential for adhesion-induced stress fiber formation and cofilin phosphorylation. Marcoux, N., Vuori, K. Cell. Signal. (2005) [Pubmed]
  17. Expression of the Nd1 gene is down-regulated by doxorubicin at post-transcriptional level. Takamori, Y., Matsudo, Y., Fujimura, L., Kang, M., Harada, Y., Moriya, H., Tokuhisa, T., Hatano, M. Int. J. Mol. Med. (2006) [Pubmed]
  18. Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation. Onabajo, O.O., Seeley, M.K., Kale, A., Qualmann, B., Kessels, M., Han, J., Tan, T.H., Song, W. J. Immunol. (2008) [Pubmed]
  19. The novel dominant mutation Dspd leads to a severe spermiogenesis defect in mice. Kai, M., Irie, M., Okutsu, T., Inoue, K., Ogonuki, N., Miki, H., Yokoyama, M., Migishima, R., Muguruma, K., Fujimura, H., Kohda, T., Ogura, A., Kaneko-Ishino, T., Ishino, F. Biol. Reprod. (2004) [Pubmed]
  20. Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinase. Didichenko, S.A., Segal, A.W., Thelen, M. FEBS Lett. (2000) [Pubmed]
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