Gene Review:
Syk - spleen tyrosine kinase
Rattus norvegicus
Synonyms:
Spleen tyrosine kinase, Tyrosine-protein kinase SYK, p72Syk
Paolini,
Molfetta,
Beitz,
Zhang,
Scharenberg,
Piccoli,
Frati,
Siraganian,
Santoni,
Zhang,
Berenstein,
Siraganian,
- Phosphorylation and recruitment of Syk by immunoreceptor tyrosine-based activation motif-based phosphorylation of tamalin. Hirose, M., Kitano, J., Nakajima, Y., Moriyoshi, K., Yanagi, S., Yamamura, H., Muto, T., Jingami, H., Nakanishi, S. J. Biol. Chem. (2004)
- Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation. Stenton, G.R., Kim, M.K., Nohara, O., Chen, C.F., Hirji, N., Wills, F.L., Gilchrist, M., Hwang, P.H., Park, J.G., Finlay, W., Jones, R.L., Befus, A.D., Schreiber, A.D. J. Immunol. (2000)
- Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release. Shefler, I., Sagi-Eisenberg, R. J. Immunol. (2001)
- Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase. Stenton, G.R., Ulanova, M., Déry, R.E., Merani, S., Kim, M.K., Gilchrist, M., Puttagunta, L., Musat-Marcu, S., James, D., Schreiber, A.D., Befus, A.D. J. Immunol. (2002)
- Intracellular single-chain variable fragments directed to the Src homology 2 domains of Syk partially inhibit Fc epsilon RI signaling in the RBL-2H3 cell line. Dauvillier, S., Mérida, P., Visintin, M., Cattaneo, A., Bonnerot, C., Dariavach, P. J. Immunol. (2002)
- Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. Zhang, J., Berenstein, E.H., Evans, R.L., Siraganian, R.P. J. Exp. Med. (1996)
- High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT. Wilson, B.S., Pfeiffer, J.R., Surviladze, Z., Gaudet, E.A., Oliver, J.M. J. Cell Biol. (2001)
- Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells. Paolini, R., Molfetta, R., Beitz, L.O., Zhang, J., Scharenberg, A.M., Piccoli, M., Frati, L., Siraganian, R., Santoni, A. J. Biol. Chem. (2002)
- Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase. Hong, J.J., Yankee, T.M., Harrison, M.L., Geahlen, R.L. J. Biol. Chem. (2002)
- Compartmentalized IgE receptor-mediated signal transduction in living cells. Stauffer, T.P., Meyer, T. J. Cell Biol. (1997)
- Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells. Zhang, J., Berenstein, E., Siraganian, R.P. Mol. Cell. Biol. (2002)
- SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling. Sada, K., Zhang, J., Siraganian, R.P. Blood (2001)
- Alpha-melanocyte stimulating hormone protects against H2O2-induced inhibition of wound restitution in IEC-6 cells via a Syk kinase- and NF-kappabeta-dependent mechanism. Zou, L., Sato, N., Kone, B.C. Shock (2004)
- Requirement for a negative charge at threonine 60 of the FcRgamma for complete activation of Syk. Swann, P.G., Odom, S., Zhou, Y.J., Szallasi, Z., Blumberg, P.M., Draber, P., Rivera, J. J. Biol. Chem. (1999)
- Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors. Amoui, M., Dráberová, L., Tolar, P., Dráber, P. Eur. J. Immunol. (1997)
- Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic leukemia cells. Tolar, P., Dráberová, L., Dráber, P. Eur. J. Immunol. (1997)
- Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domains. Taylor, J.A., Karas, J.L., Ram, M.K., Green, O.M., Seidel-Dugan, C. Mol. Cell. Biol. (1995)
- The protein tyrosine kinase syk activity is reduced by clustering the mast cell function-associated antigen. Xu, R., Pecht, I. Eur. J. Immunol. (2001)
- Cutting edge: extracellular signal-regulated kinase activates syk: a new potential feedback regulation of Fc epsilon receptor signaling. Xu, R., Seger, R., Pecht, I. J. Immunol. (1999)
- Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2. Jabril-Cuenod, B., Zhang, C., Scharenberg, A.M., Paolini, R., Numerof, R., Beaven, M.A., Kinet, J.P. J. Biol. Chem. (1996)
- Activation of macrophage CD8: pharmacological studies of TNF and IL-1 beta production. Lin, T.J., Hirji, N., Stenton, G.R., Gilchrist, M., Grill, B.J., Schreiber, A.D., Befus, A.D. J. Immunol. (2000)
- Overcoming the signaling defect of Lyn-sequestering, signal-curtailing FcepsilonRI dimers: aggregated dimers can dissociate from Lyn and form signaling complexes with Syk. Lara, M., Ortega, E., Pecht, I., Pfeiffer, J.R., Martinez, A.M., Lee, R.J., Surviladze, Z., Wilson, B.S., Oliver, J.M. J. Immunol. (2001)