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Prkar1b  -  protein kinase, cAMP dependent regulatory,...

Rattus norvegicus

Synonyms: RGD1563094, RIbeta, cAMP-dependent protein kinase type I-beta regulatory subunit
 
 
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High impact information on Prkar1b

 

Biological context of Prkar1b

  • The largest open reading frame was preceded by a short out-of-phase open reading frame, which is not seen in the corresponding mouse RI beta cDNA due to a single base substitution [5].
  • A tentative explanation is related to the different biochemical properties of the four regulatory subunit isoforms (RI alpha and RI beta, RII alpha and RII beta) and to their differential cell and tissue distribution [6].
  • In this study, we document the presence of significant mRNA levels for 5 different PKA subunits (RI alpha, RI beta, RII alpha, RII beta, and C alpha) in germ cells and demonstrate differential expression patterns for these subunits during spermatogenesis [7].
  • Messenger RNAs for RI (RI alpha and RI beta) and C alpha appear to be induced at premeiotic germ cell stages, whereas mRNAs for RII (RII alpha and RII beta) are first expressed at haploid stages [7].
  • Cells also were treated with either phorbol-12-myristate-13-acetate or dibutyryl-cAMP, and the gene expression for RI alpha, RI beta, RII alpha and RII beta of PKA was examined [8].
 

Anatomical context of Prkar1b

 

Associations of Prkar1b with chemical compounds

  • Rat RI beta isoform of type I regulatory subunit of cyclic adenosine monophosphate-dependent protein kinase: cDNA sequence analysis, mRNA tissue specificity, and rat/mouse difference in expression in testis [5].
 

Regulatory relationships of Prkar1b

  • CONCLUSIONS: The reduction of the RI beta subunit in the rat DF at day 3 may result in an elevated PKA activity to trigger the maximal burst of gene expression of MCP-1 and CSF-1 seen at this time [8].
 

Other interactions of Prkar1b

  • None of the antipsychotics caused any change in the expression of the Cat alpha-, RI alpha-, or RI beta-subunit isoform [11].
  • However, aggregation of TEC-21 did not induce changes in density of IgE-Fc epsilon RI complexes, tyrosine phosphorylation of Fc epsilon RI beta and gamma subunits, and co-aggregation of Lyn kinase [12].
  • Based upon recent reports that the rat testis exhibits mRNAs for cAMP-dependent protein kinase (A-kinase) regulatory (R) subunits RI alpha, RI beta, RII alpha, and RII beta, this study was designed to identify R proteins present in extracts of germ cell-rich testis from adult and Sertoli cell-enriched, germ cell-poor testis from 14-15-day-old rats [13].
 

Analytical, diagnostic and therapeutic context of Prkar1b

  • Moreover no Fc epsilon RI beta-subunit-expressing and no c-kit-expressing cells were detectable in the skin of Ws/Ws rats by in situ hybridization histochemistry [3].
  • Because c-kit messenger RNA was normally expressed at least in the brain of Ws/Ws rats despite the small deletion, we examined the expression of Fc epsilon RI beta-subunit and c-kit messenger RNA in the skin and stomach of Ws/Ws rats by reverse transcriptase modification of polymerase chain reaction [3].
  • The human recombinant RI beta protein migrated at 55 kDa on SDS-PAGE and displayed immunoreactivity with an anti-human RI beta antiserum [4].
  • For C alpha, C beta, RI beta, and RII alpha, Northern blot analysis revealed single mRNAs with sizes of 2.4, 4.5, 2.8, and 6.0 kilobases (kb), respectively [9].
  • The 53 kDa RI beta protein predicted by mRNA studies was only tentatively identified by Western blot analysis [13].

References

  1. Bivalent ligands with rigid double-stranded DNA spacers reveal structural constraints on signaling by Fc epsilon RI. Paar, J.M., Harris, N.T., Holowka, D., Baird, B. J. Immunol. (2002) [Pubmed]
  2. The anti-ganglioside monoclonal antibody AA4 induces protein tyrosine phosphorylations, but not degranulation, in rat basophilic leukemia cells. Swaim, W.D., Minoguchi, K., Oliver, C., Hamawy, M.M., Kihara, H., Stephan, V., Berenstein, E.H., Siraganian, R.P. J. Biol. Chem. (1994) [Pubmed]
  3. Absence of immature mast cells in the skin of Ws/Ws rats with a small deletion at tyrosine kinase domain of the c-kit gene. Onoue, H., Maeyama, K., Nomura, S., Kasugai, T., Tei, H., Kim, H.M., Watanabe, T., Kitamura, Y. Am. J. Pathol. (1993) [Pubmed]
  4. Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. Solberg, R., Taskén, K., Wen, W., Coghlan, V.M., Meinkoth, J.L., Scott, J.D., Jahnsen, T., Taylor, S.S. Exp. Cell Res. (1994) [Pubmed]
  5. Rat RI beta isoform of type I regulatory subunit of cyclic adenosine monophosphate-dependent protein kinase: cDNA sequence analysis, mRNA tissue specificity, and rat/mouse difference in expression in testis. Massa, J.S., Fellows, R.E., Maurer, R.A. Mol. Reprod. Dev. (1990) [Pubmed]
  6. Clustered distribution of cAMP-dependent protein kinase regulatory isoform RI alpha during the development of the rat brain. Mucignat-Caretta, C., Caretta, A. J. Comp. Neurol. (2002) [Pubmed]
  7. Subunits of cyclic adenosine 3',5'-monophosphate-dependent protein kinase show differential and distinct expression patterns during germ cell differentiation: alternative polyadenylation in germ cells gives rise to unique smaller-sized mRNA species. Oyen, O., Myklebust, F., Scott, J.D., Cadd, G.G., McKnight, G.S., Hansson, V., Jahnsen, T. Biol. Reprod. (1990) [Pubmed]
  8. Protein kinase A expression and its possible roles in regulating tooth eruption genes in the dental follicle. Yao, S., Wise, G.E. Med. Sci. Monit. (2003) [Pubmed]
  9. Messenger ribonucleic acids for alpha- and beta-isoforms of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunits present in the anterior pituitary: regulation of RII beta and C alpha gene expression by the cyclic nucleotide and phorbol ester. Garrel, G., Lerrant, Y., Ribot, G., Counis, R. Endocrinology (1993) [Pubmed]
  10. Stage- and cell-specific expression of cyclic adenosine 3',5'-monophosphate-dependent protein kinases in rat seminiferous epithelium. Lönnerberg, P., Parvinen, M., Jahnsen, T., Hansson, V., Persson, H. Biol. Reprod. (1992) [Pubmed]
  11. Differential effects of haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. Dwivedi, Y., Rizavi, H.S., Pandey, G.N. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  12. A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fc epsilon receptor. Hálová, I., Dráberová, L., Dráber, P. Int. Immunol. (2002) [Pubmed]
  13. cAMP-dependent protein kinases in the rat testis: regulatory and catalytic subunit associations. Weiss, J., DeManno, D.A., Cutler, R.E., Brooks, E.J., Erlichman, J., Sanwal, B.D., Hunzicker-Dunn, M. Biochim. Biophys. Acta (1992) [Pubmed]
 
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