The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

BLOC1S6  -  biogenesis of lysosomal organelles complex...

Homo sapiens

Synonyms: BLOC-1 subunit 6, BLOS6, Biogenesis of lysosome-related organelles complex 1 subunit 6, HPS9, PA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PLDN

  • One amino acid substitution in the PA gene, encoding a protein involved in virus RNA replication, and one amino acid substitution in the haemagglutinin (HA) protein were observed [1].
  • Five factors were associated with a decrement in CrCl greater than the average decrease (17.6%): presence of hydronephrosis, age <50, no history of cisplatin treatment, a BED to gross adenopathy exceeding mean BED, and salvage treatment of PA node recurrence [2].

High impact information on PLDN


Biological context of PLDN


Associations of PLDN with chemical compounds


Other interactions of PLDN

  • Seven major erythrocyte membrane proteins, alpha-and beta-spectrin, ankyrin 2.1, band 3 (anion-exchanger), 4.1a and b, and 4.2 (pallidin), were separated and identified by SDS-CGE method [10].

Analytical, diagnostic and therapeutic context of PLDN

  • NMR titration studies have also revealed that 3 binds to the CRD2 with a potency similar in magnitude to PA but much less potently than 1 [11].


  1. Molecular analysis of highly pathogenic avian influenza virus of subtype H5N1 isolated from wild birds and mammals in northern Germany. Weber, S., Harder, T., Starick, E., Beer, M., Werner, O., Hoffmann, B., Mettenleiter, T.C., Mundt, E. J. Gen. Virol. (2007) [Pubmed]
  2. The potential nephrotoxic effects of intensity modulated radiotherapy delivered to the para-aortic area of women with gynecologic malignancies: preliminary results. Varlotto, J.M., Gerszten, K., Heron, D.E., Comerci, J., Gautam, S., Selvaraj, R., Lalonde, R., Chura, J.C. Am. J. Clin. Oncol. (2006) [Pubmed]
  3. Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins. Azim, A.C., Marfatia, S.M., Korsgren, C., Dotimas, E., Cohen, C.M., Chishti, A.H. Biochemistry (1996) [Pubmed]
  4. Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. Moriyama, K., Bonifacino, J.S. Traffic (2002) [Pubmed]
  5. Human erythrocyte membrane protein band 4.2 (pallidin). Cohen, C.M., Dotimas, E., Korsgren, C. Semin. Hematol. (1993) [Pubmed]
  6. Structural domain mapping and phosphorylation of human erythrocyte pallidin (band 4.2). Dotimas, E., Speicher, D.W., GuptaRoy, B., Cohen, C.M. Biochim. Biophys. Acta (1993) [Pubmed]
  7. Specific inclusion mode of guest compounds in the amylose complex analyzed by solid state NMR spectroscopy. Tozuka, Y., Takeshita, A., Nagae, A., Wongmekiat, A., Moribe, K., Oguchi, T., Yamamoto, K. Chem. Pharm. Bull. (2006) [Pubmed]
  8. Oriented attachment-based assembly of dendritic silver nanostructures at room temperature. Lu, L., Kobayashi, A., Kikkawa, Y., Tawa, K., Ozaki, Y. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical (2006) [Pubmed]
  9. Pallidin. Purification and characterization of a carbohydrate-binding protein from Polysphondylium pallidum implicated in intercellular adhesion. Simpson, D.L., Rosen, S.D., Barondes, S.H. Biochim. Biophys. Acta (1975) [Pubmed]
  10. Capillary gel electrophoresis: separation of major erythrocyte membrane proteins. Lin, C., Cotton, F., Boutique, C., Dhermy, D., Vertongen, F., Gulbis, B. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  11. Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process. Hale, K.J., Frigerio, M., Manaviazar, S., Hummersone, M.G., Fillingham, I.J., Barsukov, I.G., Damblon, C.F., Gescher, A., Roberts, G.C. Org. Lett. (2003) [Pubmed]
WikiGenes - Universities