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Gene Review

Cbr1  -  carbonyl reductase 1

Mus musculus

Synonyms: AW261796, CR, Cbr, NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, ...
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Disease relevance of Cbr1

  • Using the pET-28a expression vector, recombinant CHO-CR (rCHO-CR) was expressed in Escherichia coli BL21 (DE3) cells and purified with a Ni2+-affinity resin to homogeneity with a 35% yield. rCHO-CR had broad substrate specificity towards xenobiotic carbonyl compounds [1].
  • Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1 [2].
  • CR supplementation significantly attenuated weight loss in tumor-bearing mice without changing food intake or tumor growth [3].
  • CR supplementation did not affect food intake, body weight, nutritional parameters and IL-6 levels in non-tumor-bearing mice [3].
  • Using anti-CR antibody, immunohistochemical staining was performed on 73 epithelial ovarian cancers, 13 borderline malignant tumours, and 25 benign ovarian tumours for a total of 111 specimens [4].

High impact information on Cbr1


Chemical compound and disease context of Cbr1


Biological context of Cbr1


Anatomical context of Cbr1


Associations of Cbr1 with chemical compounds

  • Mammalian carbonyl reductase (EC is an enzyme that can catalyze the reduction of many carbonyl compounds, using NAD(P)H [1].
  • This is the first three-dimensional structure of a carbonyl reductase, and MLCR is the first member of the SDR family to be solved in complex with NADPH (rather than NADH) [14].
  • These properties, coupled with the activity of CBR with a range of aliphatic and aromatic aldehydes, ketones and quinones, distinguish it from other AHRs [11].
  • The enzyme involved was characterized as a NADPH-dependent carbonyl reductase which is strongly inhibited by the plant flavonoid quercitrin but which shows no sensitivity to phenobarbital [15].
  • Injection of a single dose of naphthalene led to significant impairment of carbonyl reductase activity and of microsomal mixed-function oxidase activities in mouse lung, with a marked decrease in both activity and immunoreactive staining in the bronchiolar epithelial cells [16].

Other interactions of Cbr1

  • Two of these markers further define the region containing the weaver gene to a 3.9-cM segment between Cbr and Pcp-4 [17].
  • These findings may have potentially important implications for smokers who express low levels of 11beta-HSD 1/NNK carbonyl reductase and/or are concurrently being exposed to 11beta-HSD 1 modulators [12].

Analytical, diagnostic and therapeutic context of Cbr1


  1. Cloning and bacterial expression of monomeric short-chain dehydrogenase/reductase (carbonyl reductase) from CHO-K1 cells. Terada, T., Sugihara, Y., Nakamura, K., Sato, R., Inazu, N., Maeda, M. Eur. J. Biochem. (2000) [Pubmed]
  2. Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1. Olson, L.E., Bedja, D., Alvey, S.J., Cardounel, A.J., Gabrielson, K.L., Reeves, R.H. Cancer Res. (2003) [Pubmed]
  3. Anticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26/clone 20 adenocarcinoma. Iizuka, N., Hazama, S., Yoshimura, K., Yoshino, S., Tangoku, A., Miyamoto, K., Okita, K., Oka, M. Int. J. Cancer (2002) [Pubmed]
  4. Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer. Umemoto, M., Yokoyama, Y., Sato, S., Tsuchida, S., Al-Mulla, F., Saito, Y. Br. J. Cancer (2001) [Pubmed]
  5. Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Cabin, D.E., McKee-Johnson, J.W., Matesic, L.E., Wiltshire, T., Rue, E.E., Mjaatvedt, A.E., Huo, Y.K., Korenberg, J.R., Reeves, R.H. Genome Res. (1998) [Pubmed]
  6. Human 11beta-hydroxysteroid dehydrogenase 1/carbonyl reductase: recombinant expression in the yeast Pichia pastoris and Escherichia coli. Blum, A., Martin, H.J., Maser, E. Toxicology (2000) [Pubmed]
  7. Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21. Pletcher, M.T., Wiltshire, T., Cabin, D.E., Villanueva, M., Reeves, R.H. Genomics (2001) [Pubmed]
  8. Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum: murine genes that express cbr map to chromosomes 16 and 11. Wei, J., Dlouhy, S.R., Hara, A., Ghetti, B., Hodes, M.E. Genomics (1996) [Pubmed]
  9. Hamster sperm protein, p26h: a member of the short-chain dehydrogenase/reductase superfamily. Gaudreault, C., Lé garé, C., Bérubé, B., Sullivan, R. Biol. Reprod. (1999) [Pubmed]
  10. Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR, and CBR--to two different chromosomes in the marsupial species Macropus eugenii. Brookes, S., Maccarone, P., de Haan, J.B., Tymms, M., Forrest, G.L., Graves, J.A., Kola, I. Cytogenet. Cell Genet. (1992) [Pubmed]
  11. Lung carbonyl reductase in the mouse: biochemical and catalytic properties. Moxon, L.N., Holmes, R.S. Prog. Clin. Biol. Res. (1987) [Pubmed]
  12. 11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes. Maser, E. Cancer Res. (1998) [Pubmed]
  13. A novel membrane associated carbonyl reducing enzyme is present in smooth endoplasmic reticulum of mouse liver. Ahlers, T., Bode, H.P., Netter, K.J., Maser, E. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  14. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Tanaka, N., Nonaka, T., Nakanishi, M., Deyashiki, Y., Hara, A., Mitsui, Y. Structure (1996) [Pubmed]
  15. Reductive metabolism of metyrapone by a quercitrin-sensitive ketone reductase in mouse liver cytosol. Maser, E., Netter, K.J. Biochem. Pharmacol. (1991) [Pubmed]
  16. Localization of pulmonary carbonyl reductase in guinea pig and mouse: enzyme histochemical and immunohistochemical studies. Matsuura, K., Hara, A., Sawada, H., Bunai, Y., Ohya, I. J. Histochem. Cytochem. (1990) [Pubmed]
  17. High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and Erg on distal mouse chromosome 16. Mjaatvedt, A.E., Citron, M.P., Reeves, R.H. Genomics (1993) [Pubmed]
  18. Structure of the 5'-flanking regulatory region of the mouse gene encoding the clearance receptor for atrial natriuretic peptide. Yanaka, N., Kotera, J., Taguchi, I., Sugiura, M., Kawashima, K., Omori, K. Eur. J. Biochem. (1996) [Pubmed]
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