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Gene Review

Pts  -  6-pyruvoyl-tetrahydropterin synthase

Rattus norvegicus

Synonyms: 6-pyruvoyl tetrahydrobiopterin synthase, PTP synthase, PTPS
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Analytical, diagnostic and therapeutic context of Pts


  1. Purification and cDNA cloning of rat 6-pyruvoyl-tetrahydropterin synthase. Inoue, Y., Kawasaki, Y., Harada, T., Hatakeyama, K., Kagamiyama, H. J. Biol. Chem. (1991) [Pubmed]
  2. The CMF-regimen. Toxicity patterns following stepwise combinations of cyclophosphamide, methotrexate and fluorouracil. De Bruijn, E.A., Driessen, O.M., Hermans, J. Int. J. Cancer (1991) [Pubmed]
  3. 6-pyruvoyl tetrahydropterin synthase from salmon liver: amino acid sequence analysis by tandem mass spectrometry. Hauer, C.R., Leimbacher, W., Hunziker, P., Neuheiser, F., Blau, N., Heizmann, C.W. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  4. Enzymatic synthesis of 6R-[U-14C]tetrahydrobiopterin from [U-14C]GTP. Hatakeyama, K., Hoshiga, M., Suzuki, S., Kagamiyama, H. Anal. Biochem. (1993) [Pubmed]
  5. Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis. Nar, H., Huber, R., Heizmann, C.W., Thöny, B., Bürgisser, D. EMBO J. (1994) [Pubmed]
  6. Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase. Ploom, T., Thöny, B., Yim, J., Lee, S., Nar, H., Leimbacher, W., Richardson, J., Huber, R., Auerbach, G. J. Mol. Biol. (1999) [Pubmed]
  7. Expression and regulation of rat 6-pyruvoyl tetrahydropterin synthase mRNA. Hirayama, K., Kapatos, G. Neurochem. Int. (1995) [Pubmed]
  8. Molecular characterization of a nonsuppressible allele (prC4) of the Drosophila purple gene. Kim, N., Kim, J., Kim, H., Park, D., Yim, J. Mol. Cells (1997) [Pubmed]
  9. Purification and characterization of 6-pyruvoyl tetrahydropterin synthase from human pituitary gland. Guzman, J., Redweik, U., Schoedon, G., Hunziker, P., Wiestler, O.D., Heizmann, C.W., Blau, N. Enzyme (1992) [Pubmed]
  10. 6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding. Bürgisser, D.M., Thöny, B., Redweik, U., Hess, D., Heizmann, C.W., Huber, R., Nar, H. J. Mol. Biol. (1995) [Pubmed]
  11. Expression and characterization of recombinant human and rat liver 6-pyruvoyl tetrahydropterin synthase. Modified cysteine residues inhibit the enzyme activity. Bürgisser, D.M., Thöny, B., Redweik, U., Hunziker, P., Heizmann, C.W., Blau, N. Eur. J. Biochem. (1994) [Pubmed]
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