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Gene Review

bi  -  bifid

Drosophila melanogaster

Synonyms: BI, CG3578, Dm-OMB, Dm-omb, Dmel\CG3578, ...
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Disease relevance of bi


High impact information on bi


Biological context of bi


Anatomical context of bi


Associations of bi with chemical compounds

  • Amperometric measurements were performed at 100 mV and -150 mV relative to the Ag/AgCl reference electrode for the mono-enzyme and bi-enzyme systems [12].

Regulatory relationships of bi

  • Mosaic analysis indicates that brk-expressing cells produce a short-range signal that can induce vein formation in adjacent omb-expressing cells [4].
  • We present evidence that Hedgehog induces X production by driving optomotor blind expression [13].

Other interactions of bi

  • The lack of optomotor-blind produces massive cell death in its expression domain, which leads to the mis-activation of the Notch pathway and the overproliferation of lateral wing cells [5].
  • Comparison of the expression profiles of H15 and optomotor-blind to the Drosophila patterns suggests modifications also in the dorsal-ventral patterning system of the legs [14].
  • At the core of the locus lies a lethal complementation group, named l(1)omb, whose mutations cause larval and pupal lethality [15].

Analytical, diagnostic and therapeutic context of bi


  1. SALL1 mutation analysis in Townes-Brocks syndrome: twelve novel mutations and expansion of the phenotype. Botzenhart, E.M., Green, A., Ilyina, H., König, R., Lowry, R.B., Lo, I.F., Shohat, M., Burke, L., McGaughran, J., Chafai, R., Pierquin, G., Michaelis, R.C., Whiteford, M.L., Simola, K.O., Rösler, B., Kohlhase, J. Hum. Mutat. (2005) [Pubmed]
  2. Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker. Sivasankaran, R., Vigano, M.A., Müller, B., Affolter, M., Basler, K. EMBO J. (2000) [Pubmed]
  3. Gypsy retrotransposon as a tool for the in vivo analysis of the regulatory region of the optomotor-blind gene in Drosophila. Tsai, S.F., Jang, C.C., Prikhod'ko, G.G., Bessarab, D.A., Tang, C.Y., Pflugfelder, G.O., Sun, Y.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. Cook, O., Biehs, B., Bier, E. Development (2004) [Pubmed]
  5. The role of the T-box gene optomotor-blind in patterning the Drosophila wing. del Alamo Rodríguez, D., Terriente Felix, J., Díaz-Benjumea, F.J. Dev. Biol. (2004) [Pubmed]
  6. The relative role of the T-domain and flanking sequences for developmental control and transcriptional regulation in protein chimeras of Drosophila OMB and ORG-1. Porsch, M., Sauer, M., Schulze, S., Bahlo, A., Roth, M., Pflugfelder, G.O. Mech. Dev. (2005) [Pubmed]
  7. Transcript identification in the optomotor-blind locus of Drosophila melanogaster by intragenic recombination mapping and PCR-aided sequence analysis of lethal point mutations. Poeck, B., Balles, J., Pflugfelder, G.O. Mol. Gen. Genet. (1993) [Pubmed]
  8. The lethal(1)optomotor-blind gene of Drosophila melanogaster is a major organizer of optic lobe development: isolation and characterization of the gene. Pflugfelder, G.O., Roth, H., Poeck, B., Kerscher, S., Schwarz, H., Jonschker, B., Heisenberg, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Expression of the Drosophila optomotor-blind gene transcript in neuronal and glial cells of the developing nervous system. Poeck, B., Hofbauer, A., Pflugfelder, G.O. Development (1993) [Pubmed]
  10. Architectural patterns in branching morphogenesis in the kidney. al-Awqati, Q., Goldberg, M.R. Kidney Int. (1998) [Pubmed]
  11. Evolution of dorsal-ventral axis formation in arthropod appendages: H15 and optomotor-blind/bifid-type T-box genes in the millipede Glomeris marginata (Myriapoda: Diplopoda). Prpic, N.M., Janssen, R., Damen, W.G., Tautz, D. Evol. Dev. (2005) [Pubmed]
  12. Detection of organophosphorus insecticides with immobilized acetylcholinesterase - comparative study of two enzyme sensors. Andreescu, S., Avramescu, A., Bala, C., Magearu, V., Marty, J.L. Analytical and bioanalytical chemistry. (2002) [Pubmed]
  13. Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen. Lawrence, P.A., Casal, J., Struhl, G. Development (2002) [Pubmed]
  14. Gene expression in spider appendages reveals reversal of exd/hth spatial specificity, altered leg gap gene dynamics, and suggests divergent distal morphogen signaling. Prpic, N.M., Janssen, R., Wigand, B., Klingler, M., Damen, W.G. Dev. Biol. (2003) [Pubmed]
  15. Mutations in the proximal region of the optomotor-blind locus of Drosophila melanogaster reveal a gradient of neuroanatomical and behavioral phenotypes. Brunner, A., Wolf, R., Pflugfelder, G.O., Poeck, B., Heisenberg, M. J. Neurogenet. (1992) [Pubmed]
  16. Facilitated isolation of rare recombinants by ligase chain reaction: selection for intragenic crossover events in the Drosophila optomotor-blind gene. Balles, J., Pflugfelder, G.O. Mol. Gen. Genet. (1994) [Pubmed]
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