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Gene Review

ICT1  -  immature colon carcinoma transcript 1

Homo sapiens

Synonyms: 39S ribosomal protein L58, mitochondrial, DS-1, DS1, Digestion substraction 1, Immature colon carcinoma transcript 1 protein, ...
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Disease relevance of ICT1

  • Furthermore, ICT-1 is also expressed in human neuroglial cells such as oligodendroglioma, glioblastoma multiforme, Ewing's sarcoma, and cerebellar astrocyte [1].
  • The Hep G2 cells supported the growth of the simian strain rhesus rotavirus (MMU 18006), a strain currently being used in vaccine trails, but did not support the growth of any human strain (D, DS1, Price or ST3) [2].
  • The sensitivity of DS1 in detecting pancreatic cancer was 36% with a specificity of 90% and an efficiency of 82% [3].
  • By constructing miniplasmids of pCAR1 and testing their establishment in Pseudomonas putida DS1, we show that pCAR1 replication is due to the repA gene and its upstream DNA region [4].
  • Thyroid function parameters and immunoglobulin concentrations in sera of outpatients with Down's syndrome (DS, n = 110) of different ages (DS1 = 1-9 years; DS2 = 6-15; DS3 = 15-35) were compared with those of age-matched controls (n = 110) [5].

High impact information on ICT1

  • However, D6S461, just outside the HLA region, showed significant evidence for linkage disequilibrium by the transmission disequilibrium test (TDT), in all three data sets (for DS1 chi2 = 10.8, adjusted P < 0.01)(DS2 and DS3 chi2 = 10.9, P < 0.0005), suggesting a modest susceptibility locus in this region [6].
  • We report a genome search using 257 microsatellite markers with average spacing of 15.2 cM in 100 sibling pairs (Table 1, data set 1 - DS1) [6].
  • Extensive footprinting studies by DNase I, methylation protection, and hydroxyl radicals indicate MerR stays bound to DS1 even on addition of Hg(II) and shares no interaction in vitro with a second dyad symmetry element, DS2, centered at -79/-80.(ABSTRACT TRUNCATED AT 250 WORDS)[7]
  • To investigate the associated DS-1 genogroup characteristics, subgroup (VP6) enzyme-linked immunosorbent assay, polyacrylamide gel electrophoresis, and P genotyping were performed on 10 G2 strains [8].
  • Alterations in the characteristic DS-1 genogroup gene constellations were more likely to occur in the VP4 gene, and three genotypes were observed: P[4], P[6], and a dual P[4]-P[6] type [8].

Chemical compound and disease context of ICT1

  • On the other hand, human rotaviruses Wa and DS1, and the variant nar3, bound to cells two to three times more rapidly in the absence of SA [9].

Biological context of ICT1


Anatomical context of ICT1

  • The ICT-1 antigen is expressed in 50-70% of total thymocytes, but not in resting or PHA-activated peripheral blood T-cells and bone marrow cells [1].
  • The primary structure of the region in the outer layer protein VP3, containing the two sites associated with trypsin enhancement of infectivity of rotavirus was found to be greatly conserved in cultivable human rotavirus serotypes 1 (Wa), 2 (DS1), and 3 (P) and in four human rotaviruses directly purified from feces [11].
  • RESULTS: In the period with ongoing antral phase-III activity (early duodenal phase III) the antral pressure waves were antegrade, but in the juxtapyloric duodenum (DS1) retrograde waves predominated (median, 66%; interquartile range (IQR), 33-83%); that is, most duodenal pressure waves were directed against the antral ones [12].

Associations of ICT1 with chemical compounds

  • The 50% detection limits were: ICT1, 3.28; ICT2, 4.86; KAT, 6.36; MM, 9.37; CB, 11.42; DM, 12.40; Q, 16.98; PS, 20; AC, 31.15 and OP, 91.16 P/microL [13].
  • A. methanolica wild-type cells grown on glucose mineral medium normally possess a bifunctional CM/DAHP synthase protein complex (with DS1, a plant-type DAHP synthase) [14].
  • DS1 exhibits a reduced k(cat) for hypoxanthine and guanine, while its K(m) for these oxopurine bases remains largely unchanged [10].
  • Four chimeric enzymes were engineered (DS1-DS4), of which the chimeric enzyme, DS1, in which the first 49 residues of human HGPRT were replaced with the corresponding residues from the P. falciparum enzyme, exhibited additional specificity for xanthine [10].
  • After 10 days (DS1) and 21 days (DS2), a 4-hour DS using 30 mL icodextrin solution was performed in conscious animals [15].

Other interactions of ICT1


Analytical, diagnostic and therapeutic context of ICT1

  • In the 13 patients without neoadjuvant therapy, the MVD of the DS2 lesions (89.1 +/- 18.9) was significantly higher than that of the DS0 lesions (59.3 +/- 32.5, P <0.01) and DS1 lesions (55.9 +/- 20.9, P <0.005) [17].


  1. A novel T-cell differentiation antigen expressed in immature human thymocytes and neuroglial cells. Bae, Y.M., Kim, T.J., Park, W.S., Chung, D.H., Choi, E.Y., Lee, G.K., Song, H.G., Kim, C.W., Kim, B.K., Ahn, H.S. Cell. Immunol. (1995) [Pubmed]
  2. Growth of group A rotaviruses in a human liver cell line. Schwarz, K.B., Moore, T.J., Willoughby, R.E., Wee, S.B., Vonderfecht, S.L., Yolken, R.H. Hepatology (1990) [Pubmed]
  3. A prospective study of serum tumour markers carcinoembryonic antigen, carbohydrate antigens 50 and 242, tissue polypeptide antigen and tissue polypeptide specific antigen in the diagnosis of pancreatic cancer with special reference to multivariate diagnostic score. Pasanen, P.A., Eskelinen, M., Partanen, K., Pikkarainen, P., Penttilä, I., Alhava, E. Br. J. Cancer (1994) [Pubmed]
  4. Characterization of the Replication, Maintenance, and Transfer Features of the IncP-7 Plasmid pCAR1, Which Carries Genes Involved in Carbazole and Dioxin Degradation. Shintani, M., Yano, H., Habe, H., Omori, T., Yamane, H., Tsuda, M., Nojiri, H. Appl. Environ. Microbiol. (2006) [Pubmed]
  5. Thyroid function and plasma immunoglobulins in subjects with Down's syndrome (DS) during ontogenesis and zinc therapy. Sustrová, M., Strbák, V. J. Endocrinol. Invest. (1994) [Pubmed]
  6. A full genome search in multiple sclerosis. Ebers, G.C., Kukay, K., Bulman, D.E., Sadovnick, A.D., Rice, G., Anderson, C., Armstrong, H., Cousin, K., Bell, R.B., Hader, W., Paty, D.W., Hashimoto, S., Oger, J., Duquette, P., Warren, S., Gray, T., O'Connor, P., Nath, A., Auty, A., Metz, L., Francis, G., Paulseth, J.E., Murray, T.J., Pryse-Phillips, W., Nelson, R., Freedman, M., Brunet, D., Bouchard, J.P., Hinds, D., Risch, N. Nat. Genet. (1996) [Pubmed]
  7. Transcriptional switching by the metalloregulatory MerR protein: initial characterization of DNA and mercury (II) binding activities. Shewchuk, L.M., Verdine, G.L., Walsh, C.T. Biochemistry (1989) [Pubmed]
  8. Antigenic and genetic characterization of serotype G2 human rotavirus strains from the African continent. Page, N.A., Steele, A.D. J. Clin. Microbiol. (2004) [Pubmed]
  9. Entry of rotaviruses is a multistep process. Méndez, E., López, S., Cuadras, M.A., Romero, P., Arias, C.F. Virology (1999) [Pubmed]
  10. Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes. Sujay Subbayya, I.N., Sukumaran, S., Shivashankar, K., Balaram, H. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  11. Conservation in rotaviruses of the protein region containing the two sites associated with trypsin enhancement of infectivity. López, S., Arias, C.F., Méndez, E., Espejo, R.T. Virology (1986) [Pubmed]
  12. Duodenal juxtapyloric retroperistalsis in the interdigestive state in humans. Castedal, M., Björnsson, E., Abrahamsson, H. Scand. J. Gastroenterol. (1997) [Pubmed]
  13. Field and laboratory comparative evaluation of ten rapid malaria diagnostic tests. Craig, M.H., Bredenkamp, B.L., Williams, C.H., Rossouw, E.J., Kelly, V.J., Kleinschmidt, I., Martineau, A., Henry, G.F. Trans. R. Soc. Trop. Med. Hyg. (2002) [Pubmed]
  14. (De)regulation of key enzyme steps in the shikimate pathway and phenylalanine-specific pathway of the actinomycete Amycolatopsis methanolica. Kloosterman, H., Hessels, G.I., Vrijbloed, J.W., Euverink, G.J., Dijkhuizen, L. Microbiology (Reading, Engl.) (2003) [Pubmed]
  15. The effect of icodextrin-based solutions on peritoneal transport in rats undergoing chronic peritoneal dialysis. Pawlaczyk, K., Garcia-Lopez, E., Kuzlan-Pawlaczyk, M., Heimbürger, O., Bergström, J., Breborowicz, A., Lindholm, B. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2001) [Pubmed]
  16. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation. van Belzen, N., Diesveld, M.P., van der Made, A.C., Nozawa, Y., Dinjens, W.N., Vlietstra, R., Trapman, J., Bosman, F.T. Eur. J. Biochem. (1995) [Pubmed]
  17. Possible use of transrectal power Doppler imaging as an indicator of microvascular density of prostate cancer. Nakanouchi, T., Okihara, K., Kojima, M., Ukimura, O., Yokoyama, K., Takamatsu, T., Miki, T. Urology (2001) [Pubmed]
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