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Gene Review

Slit2  -  slit homolog 2 (Drosophila)

Rattus norvegicus

Synonyms: Slit homolog 2 protein, Slit-2
 
 
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Disease relevance of Slit2

  • In a rat model of glomerulonephritis, endogenous glomerular Slit2 expression fell after disease induction, and its inhibition during the early disease period accelerated inflammation [1].
  • This action of Slit2 as a growth inhibitor of retinal axons and the expression patterns of slit1 and slit2 correlate with the fasciculation and innervation patterns of RGC axons within the diencephalon and implicate the Slits as components of the axon repellent activity associated with the hypothalamus and epithalamus [2].
 

High impact information on Slit2

 

Biological context of Slit2

 

Anatomical context of Slit2

 

Associations of Slit2 with chemical compounds

  • Sensory axon response to substrate-bound Slit2 is modulated by laminin and cyclic GMP [9].
 

Other interactions of Slit2

  • However, when the Slit2 stripes were coated on fibronectin, DRG axons still avoided full-length Slit2 but grew preferentially on Slit2-N [9].

References

  1. Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Kanellis, J., Garcia, G.E., Li, P., Parra, G., Wilson, C.B., Rao, Y., Han, S., Smith, C.W., Johnson, R.J., Wu, J.Y., Feng, L. Am. J. Pathol. (2004) [Pubmed]
  2. Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon. Ringstedt, T., Braisted, J.E., Brose, K., Kidd, T., Goodman, C., Tessier-Lavigne, M., O'Leary, D.D. J. Neurosci. (2000) [Pubmed]
  3. Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein. Hu, H. Nat. Neurosci. (2001) [Pubmed]
  4. Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration. Xu, H.T., Yuan, X.B., Guan, C.B., Duan, S., Wu, C.P., Feng, L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Maternal perinatal undernutrition alters neuronal and neuroendocrine differentiation in the rat adrenal medulla at weaning. Molendi-Coste, O., Grumolato, L., Laborie, C., Lesage, J., Maubert, E., Ghzili, H., Vaudry, H., Anouar, Y., Breton, C., Vieau, D. Endocrinology (2006) [Pubmed]
  6. Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005) [Pubmed]
  7. Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation. Liu, D., Hou, J., Hu, X., Wang, X., Xiao, Y., Mou, Y., De Leon, H. Circ. Res. (2006) [Pubmed]
  8. Expression of a chemorepellent factor, Slit2, in peripheral nerve regeneration. Tanno, T., Fujiwara, A., Takenaka, S., Kuwamura, M., Tsuyama, S. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
  9. Sensory axon response to substrate-bound Slit2 is modulated by laminin and cyclic GMP. Nguyen-Ba-Charvet, K.T., Brose, K., Marillat, V., Sotelo, C., Tessier-Lavigne, M., Chédotal, A. Mol. Cell. Neurosci. (2001) [Pubmed]
 
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