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Gene Review

JAG2  -  jagged 2

Homo sapiens

Synonyms: HJ2, Jagged2, Protein jagged-2, SER2, hJ2
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Disease relevance of JAG2


High impact information on JAG2

  • Taken together, these results indicate that JAG2 overexpression may be an early event in the pathogenesis of multiple myeloma involving IL-6 production [1].
  • The NOTCH ligand, JAG2, was found to be overexpressed in malignant plasma cells from multiple myeloma (MM) patients and cell lines but not in nonmalignant plasma cells from tonsils, bone marrow from healthy individuals, or patients with other malignancies [1].
  • Finally, coculture of Dl-1-expressing cells with myogenic C2 cells suppresses differentiation of C2 cells into myotubes, as previously demonstrated for Jagged-1 and Jagged-2, and also leads to an increased level of endogenous HES-1 mRNA [2].
  • Cytoplasmic localization, which may indicate Jagged-2 internalization, was found in many skeletrophin-positive myeloma cells [3].
  • Expression of Jagged-1 and Delta-4 mRNA was seen in normal and diseased liver tissue, whereas Jagged-2, Delta-1, and Delta-3 mRNA was undetectable [4].

Biological context of JAG2


Anatomical context of JAG2

  • This overexpression appears to be a consequence of hypomethylation of the JAG2 promoter in malignant plasma cells [1].
  • Transcripts of Notch 1 and Jagged 2 in the rat testis were positive throughout the examined period; these intensities became higher at day 13 after birth, coincidence with the formation of spermatocytes, and peaked at day 19 after birth [7].
  • When rat testicular tissues were cultured with anti-Notch 1 or anti-Jagged 2 antibody, round and elongated spermatids decreased after 5 and 7 days of culture, respectively, and disappeared at around 9 and 12 days of culture, respectively, with shrinkage of the diameter of seminiferous tubules [7].
  • The ligand Jagged-1 was found sporadically in the neuroepithelial cell layer in cerebral cortex of the earlier stages of development and of the spinal cord during the first trimester while Jagged-2 was not detected [8].
  • To clarify the mechanism(s) by which PS facilitates Notch signaling, we examined human Jagged-2-dependent metabolism and activity of a chimeric full-length Notchl-GFP molecule expressed in fibroblasts with heterozygous, or homozygous deletions of PS1 [9].

Other interactions of JAG2

  • The genomic sequence of the human Jagged2 (JAG2) gene, which encodes a ligand for the Notch receptors, was determined [5].
  • Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens [10].
  • These clinical manifestations and autopsy findings of the fetus are compared with those of previously published cases and the possible involvement in this pathology of the YY1 and JAG2 transcription factors and the BCL11b and SIVA-1 regulators of thymic development is discussed [11].

Analytical, diagnostic and therapeutic context of JAG2


  1. Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines. Houde, C., Li, Y., Song, L., Barton, K., Zhang, Q., Godwin, J., Nand, S., Toor, A., Alkan, S., Smadja, N.V., Avet-Loiseau, H., Lima, C.S., Miele, L., Coignet, L.J. Blood (2004) [Pubmed]
  2. Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Jarriault, S., Le Bail, O., Hirsinger, E., Pourquié, O., Logeat, F., Strong, C.F., Brou, C., Seidah, N.G., Isra l, A. Mol. Cell. Biol. (1998) [Pubmed]
  3. Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. Takeuchi, T., Adachi, Y., Ohtsuki, Y. Am. J. Pathol. (2005) [Pubmed]
  4. Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects. Nijjar, S.S., Wallace, L., Crosby, H.A., Hubscher, S.G., Strain, A.J. Am. J. Pathol. (2002) [Pubmed]
  5. Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. Deng, Y., Madan, A., Banta, A.B., Friedman, C., Trask, B.J., Hood, L., Li, L. Genomics (2000) [Pubmed]
  6. CADASIL-causing mutations do not alter Notch3 receptor processing and activation. Low, W.C., Santa, Y., Takahashi, K., Tabira, T., Kalaria, R.N. Neuroreport (2006) [Pubmed]
  7. Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. Hayashi, T., Kageyama, Y., Ishizaka, K., Xia, G., Kihara, K., Oshima, H. J. Androl. (2001) [Pubmed]
  8. Distribution of presenilin 1 and 2 and their relation to Notch receptors and ligands in human embryonic/foetal central nervous system. Kostyszyn, B., Cowburn, R.F., Seiger, A., Kjaeldgaard, A., Sundström, E. Brain Res. Dev. Brain Res. (2004) [Pubmed]
  9. Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. Martys-Zage, J.L., Kim, S.H., Berechid, B., Bingham, S.J., Chu, S., Sklar, J., Nye, J., Sisodia, S.S. J. Mol. Neurosci. (2000) [Pubmed]
  10. Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens. Euer, N.I., Kaul, S., Deissler, H., Möbus, V.J., Zeillinger, R., Weidle, U.H. Oncol. Rep. (2005) [Pubmed]
  11. Striking facial dysmorphisms and restricted thymic development in a fetus with a 6-megabase deletion of chromosome 14q. de Pater, J.M., Nikkels, P.G., Poot, M., Eleveld, M.J., Stigter, R.H., van der Sijs-Bos, C.J., Loneus, W.H., Engelen, J.J. Pediatr. Dev. Pathol. (2005) [Pubmed]
  12. Expression failure of the notch signaling system is associated with the pathogenesis of testicular germ cell tumor. Hayashi, T., Yamada, T., Kageyama, Y., Kihara, K. Tumour Biol. (2004) [Pubmed]
  13. Human follicular dendritic cells inhibit superantigen-induced T-cell proliferation by distinct mechanisms. Butch, A.W., Kelly, K.A., Willbanks, M.S., Yu, X. Blood (1999) [Pubmed]
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