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Gene Review

TECTA  -  tectorin alpha

Gallus gallus

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Disease relevance of TECTA


High impact information on TECTA

  • The 8D9 antigen, a cell surface protein isolated from chicken brain that is related to the L1 class of cell adhesion molecules, is shown to contain an activity that promotes the attachment of neurons and the outgrowth of neurites from chicken tecta and mouse cerebellum [3].
  • Immunoelectron microscopy of normal tecta demonstrated the presence of N-cadherin in the synaptic cleft, suggesting a role for this molecule in synaptic maintenance [4].
  • We have investigated how neurons in the optic tecta of embryonic day 16 chick embryos depend for survival on their afferents from the retina [5].
  • To examine the positional value of the tectal primordium, we produced ectopic tecta in the diencephalon by transplanting a part of the mesencephalic alar plate heterotopically [6].
  • When excised optic tecta are exposed to cationized ferritin for various times, ferritin micelles appear sequentially in coated pits, coated vesicles, smooth vesicles, vacuoles, and then in stacked and single disks, including some of those contacting the plasmalemma [7].

Biological context of TECTA


Anatomical context of TECTA

  • The presence of radiolabeled NCAM in the optic nerves and contralateral tecta was detected by specific immunoadsorption to a monoclonal antibody [10].
  • This asymmetry is manifested as a difference between the two halves of the forebrain and the tecta [11].
  • In cultures prepared from E10 tecta, both stain a filamentous meshwork in glial cells but not in neurons [12].
  • After 48 hours, the ultrastructure of superficial tectal layers was analyzed and compared with samples from control tecta injected with cytochrome C. NT-3 increased the number of synapses, synaptic vesicles/profile, synaptic vesicle densities, the number of docked vesicles, and the length of the synaptic profile [13].
  • Temporal RGC growth cones collapsed and retracted with a high probability from neuronal cells dissociated from posterior tecta, indicating that repellent components were enriched on posterior target neurons [14].

Associations of TECTA with chemical compounds

  • A new series of indole melatonin analogues, bearing the amido ethyl side chain attached at the N-1 position of the indole nucleus, were synthesized and tested for their affinity for the melatonin receptor isolated from quail optic tecta in a series of in vitro ligand-binding experiments using 2-[125I]iodomelatonin as the labeled ligand [15].
  • The cyclic AMP increase elicited by 2-chloroadenosine was greatly reduced in tecta from 20-day-old embryos and 2-day-old chicks [16].
  • When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein, respectively [16].
  • The putative transmitters glutamate and glycine and the neurotransmitter analogs isoproterenol and carbachol had no stimulatory effect on the cyclic AMP accumulation of tecta from 10- and 17-day-old embryos [16].
  • Fourteen days after the injection of kainic acid, during which the control tecta grow appreciably, all the superficial layers of the tectum contralateral to the kainic acid-lesioned eye, especially layers IIc and IId, were smaller than in controls, and did not differ in size from those seen in tecta contralateral to cut optic nerves [17].

Analytical, diagnostic and therapeutic context of TECTA


  1. Embryonic chick retinal ganglion cells identified "in vitro". Their survival is dependent on a factor from the optic tectum. Nurcombe, V., Bennett, M.R. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1981) [Pubmed]
  2. Interferon beta-1a prevents the effects of lipopolysaccharide on embryonic brain microvessels. Nico, B., Quondamatteo, F., Herken, R., Blumchen, T., Defazio, G., Giorelli, M., Livrea, P., Marzullo, A., Russo, G., Ribatti, D., Roncali, L. Brain Res. Dev. Brain Res. (2000) [Pubmed]
  3. An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Lagenaur, C., Lemmon, V. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Lamina-specific expression of adhesion molecules in developing chick optic tectum. Yamagata, M., Herman, J.P., Sanes, J.R. J. Neurosci. (1995) [Pubmed]
  5. Rapid onset of neuronal death induced by blockade of either axoplasmic transport or action potentials in afferent fibers during brain development. Catsicas, M., Péquignot, Y., Clarke, P.G. J. Neurosci. (1992) [Pubmed]
  6. Establishment of rostrocaudal polarity in tectal primordium: engrailed expression and subsequent tectal polarity. Itasaki, N., Ichijo, H., Hama, C., Matsuno, T., Nakamura, H. Development (1991) [Pubmed]
  7. Recycling of plasmalemma in chick tectal growth cones. Cheng, T.P., Reese, T.S. J. Neurosci. (1987) [Pubmed]
  8. Effects of enucleation on high-affinity binding sites in chick optic tecta. Por, S.B., Bondy, S.C. J. Neurochem. (1982) [Pubmed]
  9. Chick PTPsigma regulates the targeting of retinal axons within the optic tectum. Rashid-Doubell, F., McKinnell, I., Aricescu, A.R., Sajnani, G., Stoker, A. J. Neurosci. (2002) [Pubmed]
  10. Rapid axonal transport of the neural cell adhesion molecule. Garner, J.A., Watanabe, M., Rutishauser, U. J. Neurosci. (1986) [Pubmed]
  11. Brain asymmetry as a potential biomarker for developmental TCDD intoxication: a dose-response study. Henshel, D.S., Martin, J.W., DeWitt, J.C. Environ. Health Perspect. (1997) [Pubmed]
  12. Developmentally regulated and spatially restricted antigens of radial glial cells. Herman, J.P., Victor, J.C., Sanes, J.R. Dev. Dyn. (1993) [Pubmed]
  13. Presynaptic neurotrophin-3 increases the number of tectal synapses, vesicle density, and number of docked vesicles in chick embryos. Wang, X., Butowt, R., von Bartheld, C.S. J. Comp. Neurol. (2003) [Pubmed]
  14. Functional guidance components and their cellular distribution in retinotectal co-cultures. Davenport, R.W. Cell Tissue Res. (1997) [Pubmed]
  15. 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues. Tarzia, G., Diamantini, G., Di Giacomo, B., Spadoni, G., Esposti, D., Nonno, R., Lucini, V., Pannacci, M., Fraschini, F., Stankov, B.M. J. Med. Chem. (1997) [Pubmed]
  16. Development of adenosine-dependent cyclic AMP accumulation in the avian optic tectum. Ventura, A.L., Paes de Carvalho, R. Brain Res. (1987) [Pubmed]
  17. Intravitreal kainic acid severely reduces the size of the developing optic tectum in newly hatched chickens. Tung, N.N., Morgan, I.G., Ehrlich, D. Brain Res. (1987) [Pubmed]
  18. Migration and differentiation of neurons in the retina and optic tectum of the chick. Snow, R.L., Robson, J.A. Exp. Neurol. (1995) [Pubmed]
  19. Outgrowth and directional specificity of fibers from embryonic retinal transplants in the chick optic tectum. Thanos, S., Dütting, D. Brain Res. (1987) [Pubmed]
  20. Fine structural studies of synaptogenesis in the superficial layers of the chick optic tectum. McGraw, C.F., McLaughlin, B.J. J. Neurocytol. (1980) [Pubmed]
  21. Developmental variation in monosialoganglioside content of embryonic chick retina and tectum. Irwin, L.N., Bremer, E.G., Irwin, C.C., McCluer, R.H. Dev. Neurosci. (1985) [Pubmed]
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