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Gene Review

RHOH  -  ras homolog family member H

Homo sapiens

Synonyms: ARHH, GTP-binding protein TTF, Rho-related GTP-binding protein RhoH, RhoH, TTF, ...
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Disease relevance of RHOH


High impact information on RHOH

  • These data demonstrate that RhoH is required for maintenance of lymphocyte LFA-1 in a nonadhesive state [5].
  • In this study, we generated a Jurkat T cell clone, J+hi1.14, that contained low amounts of mRNA for RhoH, a leukocyte-specific inhibitory Rho family member [5].
  • Reconstitution of RhoH mRNA expression in J+hi1.14 cells reverted the adhesion phenotype to that of wild-type [5].
  • Other genes observed were SELL and LPXN, which were highly expressed in spleen, and lymphoma oncogenes, such as ARHH and TCL1 [6].
  • However, RhoH is a potent inhibitor of the activation of NFkappaB and p38 by other Rho GTPases [7].

Biological context of RHOH


Anatomical context of RHOH

  • Reduction of RhoH levels in T cells augments the response to Rac activation [7].
  • Furthermore, RhoH is dramatically down regulated after phorbol myristate acetate treatment and in Th1 cells after activation by anti-CD3 [7].
  • RhoH is encoded by a hematopoiesis-specific Rho-related gene recently identified in a fusion transcript with bcl6 in lymphoma cell lines [7].
  • This gene encodes an actin-binding protein and is the second LAZ3 partner gene, with the RhoH/TTF gene, involved in actin cytoskeleton organization [10].
  • Our results show that erythrocyte membrane modulation markedly enhanced direct Rhop-H binding to intact human erythrocytes [11].

Associations of RHOH with chemical compounds

  • RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes [5].
  • CONCLUSION: Patients with normal serum HER-2/neu receiving letrozole demonstrated a significantly greater ORR and CB and longer TTP and TTF than patients receiving tamoxifen [12].
  • Although in patients with elevated serum HER-2/neu there was no significant difference between letrozole and tamoxifen in ORR or CB, there was a strong trend favoring longer TTP and significantly longer TTF with letrozole [12].
  • A new class of pi-extended TTF-type electron donors (11 a-c) has been synthesized by Wittig-Horner olefination of bianthrone (9) with 1,3-dithiole phosphonate esters (10 a-c) [13].
  • Effects of structural factors on the pi-dimerization and/or disproportionation of the cation radical of extended TTF containing thiophene-based pi-conjugated spacers [14].

Other interactions of RHOH

  • Unlike most other small G proteins which are expressed ubiquitously, TTF was transcribed only in hemopoietic cells as a 2.2 kb transcript [15].
  • Extensive expression analysis allowed the detection of RhoH transcripts in all hematopoietic lineages (lymphoid, erythroid, myeloid), with a high level in lymphoid cells [2].
  • We studied the effects of membrane modulation on the interaction of Plasmodium falciparum rhoptry proteins of 140/130/110 kDa (Rhop-H) with human and mouse erythrocytes [11].

Analytical, diagnostic and therapeutic context of RHOH


  1. Rearrangement of the RHOH gene in a case of splenic lymphoma with villous lymphocytes. Bernicot, I., Morel, F., Le Bris, M.J., Bail, J.P., Douet-Guilbert, N., De Braekeleer, M. Cancer Genet. Cytogenet. (2006) [Pubmed]
  2. Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation. Lahousse, S., Smorowski, A.L., Denis, C., Lantoine, D., Kerckaert, J.P., Galiègue-Zouitina, S. Gene (2004) [Pubmed]
  3. Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. Preudhomme, C., Roumier, C., Hildebrand, M.P., Dallery-Prudhomme, E., Lantoine, D., Laï, J.L., Daudignon, A., Adenis, C., Bauters, F., Fenaux, P., Kerckaert, J.P., Galiègue-Zouitina, S. Oncogene (2000) [Pubmed]
  4. Thyroid metastases from renal clear cell carcinoma: a cyto-histological study of two cases. Ambrosiani, L., Declich, P., Bellone, S., Tavani, E., Pacilli, P., Guarneri, A., Rovellini, P., Bianchi, A. Advances in clinical pathology : the official journal of Adriatic Society of Pathology. (2001) [Pubmed]
  5. RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes. Cherry, L.K., Li, X., Schwab, P., Lim, B., Klickstein, L.B. Nat. Immunol. (2004) [Pubmed]
  6. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis. Ruiz-Ballesteros, E., Mollejo, M., Rodriguez, A., Camacho, F.I., Algara, P., Martinez, N., Pollán, M., Sanchez-Aguilera, A., Menarguez, J., Campo, E., Martinez, P., Mateo, M., Piris, M.A. Blood (2005) [Pubmed]
  7. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Li, X., Bu, X., Lu, B., Avraham, H., Flavell, R.A., Lim, B. Mol. Cell. Biol. (2002) [Pubmed]
  8. Evolution of the rho family of ras-like GTPases in eukaryotes. Boureux, A., Vignal, E., Faure, S., Fort, P. Mol. Biol. Evol. (2007) [Pubmed]
  9. Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization. Dallery-Prudhomme, E., Roumier, C., Denis, C., Preudhomme, C., Kerckaert, J.P., Galiegue-Zouitina, S. Genomics (1997) [Pubmed]
  10. Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma. Galiègue-Zouitina, S., Quief, S., Hildebrand, M.P., Denis, C., Detourmignies, L., Laï, J.L., Kerckaert, J.P. Genes Chromosomes Cancer (1999) [Pubmed]
  11. Plasmodium falciparum: effects of membrane modulating agents on direct binding of rhoptry proteins to human erythrocytes. Ndengele, M.M., Messineo, D.G., Sam-Yellowe, T., Harwalkar, J.A. Exp. Parasitol. (1995) [Pubmed]
  12. Serum HER-2/neu and response to the aromatase inhibitor letrozole versus tamoxifen. Lipton, A., Ali, S.M., Leitzel, K., Demers, L., Harvey, H.A., Chaudri-Ross, H.A., Brady, C., Wyld, P., Carney, W. J. Clin. Oncol. (2003) [Pubmed]
  13. Highly conjugated p-quinonoid pi-extended tetrathiafulvalene derivatives: a class of highly distorted electron donors. Díaz, M.C., Illescas, B.M., Martín, N., Viruela, R., Viruela, P.M., Ortí, E., Brede, O., Zilbermann, I., Guldi, D.M. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  14. Effects of structural factors on the pi-dimerization and/or disproportionation of the cation radical of extended TTF containing thiophene-based pi-conjugated spacers. Frère, P., Allain, M., Elandaloussi, e.l. .H., Levillain, E., Sauvage, F.X., Riou, A., Roncali, J. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  15. TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. Dallery, E., Galiègue-Zouitina, S., Collyn-d'Hooghe, M., Quief, S., Denis, C., Hildebrand, M.P., Lantoine, D., Deweindt, C., Tilly, H., Bastard, C. Oncogene (1995) [Pubmed]
  16. Nonfollicular small B-cell lymphomas: a heterogeneous group of patients with distinct clinical features and outcome. Berger, F., Felman, P., Sonet, A., Salles, G., Bastion, Y., Bryon, P.A., Coiffier, B. Blood (1994) [Pubmed]
  17. Tetrathiafulvalene derivatives as NLO-phores: synthesis, electrochemistry, Raman spectroscopy, theoretical calculations, and NLO properties of novel TTF-derived donor-pi-acceptor dyads. González, M., Segura, J.L., Seoane, C., Martín, N., Garín, J., Orduna, J., Alcalá, R., Villacampa, B., Hernández, V., López Navarrete, J.T. J. Org. Chem. (2001) [Pubmed]
  18. Plasmodium falciparum rhoptry proteins of 140/130/110 kd (Rhop-H) are located in an electron lucent compartment in the neck of the rhoptries. Sam-Yellowe, T.Y., Fujioka, H., Aikawa, M., Messineo, D.G. J. Eukaryot. Microbiol. (1995) [Pubmed]
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