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Gene Review

OLIG2  -  oligodendrocyte lineage transcription...

Homo sapiens

Synonyms: BHLHB1, BHLHE19, Class B basic helix-loop-helix protein 1, Class E basic helix-loop-helix protein 19, OLIGO2, ...
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Disease relevance of OLIG2


Psychiatry related information on OLIG2

  • It was hypothesized a priori that OLIG2 and OLIG1 were associated with OCD regardless of the presence of comorbid Tourette disorder (TD), but not with TD alone [4].
  • Finally, the formation of oligodendrocytes is triggered by an increase in the activity of bHLH factors Olig1 and Olig2 that may be coupled with a decrease in Id activity [5].

High impact information on OLIG2

  • By temporally selective interactions with other transcription factors, Olig2 first directs motor neuron fate and later switches to promoting oligodendrocyte production [6].
  • The bHLH repressor Olig2 participates in the transcriptional code governing cell fate specification in the ventral spinal cord [6].
  • At later stages, NFIA promotes migration and differentiation of astrocyte precursors, a function that is antagonized in oligodendrocyte precursors by Olig2 [7].
  • Functional analysis of PDGF signaling in these neural progenitors resonates in provocative ways with an older body of literature on PDGF autocrine loops in malignant glioma and with more recent observations on the bHLH transcription factor Olig2 [8].
  • OLIG2-positive cells corresponding to neoplastic oligodendrocytes were present in all oligodendrogliomas and oligoastrocytomas [3].

Biological context of OLIG2


Anatomical context of OLIG2


Associations of OLIG2 with chemical compounds


Regulatory relationships of OLIG2


Other interactions of OLIG2


Analytical, diagnostic and therapeutic context of OLIG2


  1. Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas. Ohnishi, A., Sawa, H., Tsuda, M., Sawamura, Y., Itoh, T., Iwasaki, Y., Nagashima, K. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  2. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. Ligon, K.L., Alberta, J.A., Kho, A.T., Weiss, J., Kwaan, M.R., Nutt, C.L., Louis, D.N., Stiles, C.D., Rowitch, D.H. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  3. OLIG2 as a specific marker of oligodendroglial tumour cells. Marie, Y., Sanson, M., Mokhtari, K., Leuraud, P., Kujas, M., Delattre, J.Y., Poirier, J., Zalc, B., Hoang-Xuan, K. Lancet (2001) [Pubmed]
  4. A Genetic Family-Based Association Study of OLIG2 in Obsessive-compulsive Disorder. Stewart, S.E., Platko, J., Fagerness, J., Birns, J., Jenike, E., Smoller, J.W., Perlis, R., Leboyer, M., Delorme, R., Chabane, N., Rauch, S.L., Jenike, M.A., Pauls, D.L. Arch. Gen. Psychiatry (2007) [Pubmed]
  5. Basic helix-loop-helix factors in cortical development. Ross, S.E., Greenberg, M.E., Stiles, C.D. Neuron (2003) [Pubmed]
  6. Cracking the transcriptional code for cell specification in the neural tube. Marquardt, T., Pfaff, S.L. Cell (2001) [Pubmed]
  7. The Transcription Factor NFIA Controls the Onset of Gliogenesis in the Developing Spinal Cord. Deneen, B., Ho, R., Lukaszewicz, A., Hochstim, C.J., Gronostajski, R.M., Anderson, D.J. Neuron (2006) [Pubmed]
  8. The bad seed: PDGF receptors link adult neural progenitors to glioma stem cells. Kesari, S., Stiles, C.D. Neuron (2006) [Pubmed]
  9. Development of NG2 neural progenitor cells requires Olig gene function. Ligon, K.L., Kesari, S., Kitada, M., Sun, T., Arnett, H.A., Alberta, J.A., Anderson, D.J., Stiles, C.D., Rowitch, D.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Shared oligodendrocyte lineage gene expression in gliomas and oligodendrocyte progenitor cells. Bouvier, C., Bartoli, C., Aguirre-Cruz, L., Virard, I., Colin, C., Fernandez, C., Gouvernet, J., Figarella-Branger, D. J. Neurosurg. (2003) [Pubmed]
  11. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Georgieva, L., Moskvina, V., Peirce, T., Norton, N., Bray, N.J., Jones, L., Holmans, P., Macgregor, S., Zammit, S., Wilkinson, J., Williams, H., Nikolov, I., Williams, N., Ivanov, D., Davis, K.L., Haroutunian, V., Buxbaum, J.D., Craddock, N., Kirov, G., Owen, M.J., O'Donovan, M.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  12. A novel function of OLIG2 to suppress human glial tumor cell growth via p27Kip1 transactivation. Tabu, K., Ohnishi, A., Sunden, Y., Suzuki, T., Tsuda, M., Tanaka, S., Sakai, T., Nagashima, K., Sawa, H. J. Cell. Sci. (2006) [Pubmed]
  13. Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Samanta, J., Kessler, J.A. Development (2004) [Pubmed]
  14. OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. Lin, Y.W., Deveney, R., Barbara, M., Iscove, N.N., Nimer, S.D., Slape, C., Aplan, P.D. Cancer Res. (2005) [Pubmed]
  15. Expression of olig2 in retinal progenitor cells. Nakamura, K., Harada, C., Namekata, K., Harada, T. Neuroreport (2006) [Pubmed]
  16. The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. Wang, J., Jani-Sait, S.N., Escalon, E.A., Carroll, A.J., de Jong, P.J., Kirsch, I.R., Aplan, P.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  17. OLIG2 is a useful immunohistochemical marker in differential diagnosis of clear cell primary CNS neoplasms. Preusser, M., Budka, H., Rössler, K., Hainfellner, J.A. Histopathology (2007) [Pubmed]
  18. The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. Usui, H., Takahashi, N., Saito, S., Ishihara, R., Aoyama, N., Ikeda, M., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Yoshida, K., Iwata, N., Inada, T., Ozaki, N. Schizophr. Res. (2006) [Pubmed]
  19. Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors. Azzarelli, B., Miravalle, L., Vidal, R. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
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