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Gene Review

mei-9  -  meiotic 9

Drosophila melanogaster

Synonyms: CG3697, DNA repair endonuclease XPF, DhR1, DmXPF, Dmel\CG3697, ...
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Disease relevance of mei-9


High impact information on mei-9


Chemical compound and disease context of mei-9


Biological context of mei-9


Anatomical context of mei-9

  • These established cell lines can therefore be used as appropriate models for both the examination of the biochemical basis of the genetic defects in the mei-9 and mus201 mutations and the role of excision-repair processes in spontaneous and induced mutation induction in eukaryotic cells [13].

Associations of mei-9 with chemical compounds


Other interactions of mei-9

  • We find that Ercc1 mutants are identical to mei-9 mutants in sensitivity to DNA-damaging agents, but have a less severe reduction in the number of meiotic crossovers [18].
  • Spontaneous mutation frequencies were higher in mei-9 and mei-41 males, and thus appropriate corrections were applied to the radiation data [1].
  • Cells derived from two nonallelic excision-defective mutants (mei-9 and mus201) exhibit the same quantitative decline in both phenomena as do control cells [19].
  • The high dose part of the curve is sensitive to oxygenation during irradiation and is affected significantly by the mutants with low fertility (mei-9, mus101 and mus302) [20].
  • This cytogenetic localization of these loci will facilitate the cloning and molecular analysis of genes controlling a key function in DNA repair and recombination (mei-9), and two fundamental neural functions (norpA and omb) [11].

Analytical, diagnostic and therapeutic context of mei-9


  1. Studies on mutagen-sensitive strains of Drosophila melanogaster. VI. The effect of DNA-repair deficiencies in spermatids, spermatocytes and spermatogonia irradiated in N2 or O2. Eeken, J.C., Sobels, F.H. Mutat. Res. (1985) [Pubmed]
  2. A cell-cycle stage-related chromosomal X-ray hypersensitivity in larval neuroblasts of Drosophila mei-9 and mei-41 mutants suggesting defective DNA double-strand break repair. Schweizer, P.M. Mutat. Res. (1989) [Pubmed]
  3. A high level of hybrid dysgenesis in Drosophila: high thermosensitivity, dependence on DNA repair, and incomplete cytotype regulation. Margulies, L. Mol. Gen. Genet. (1990) [Pubmed]
  4. denV gene of bacteriophage T4 restores DNA excision repair to mei-9 and mus201 mutants of Drosophila melanogaster. Banga, S.S., Boyd, J.B., Valerie, K., Harris, P.V., Kurz, E.M., de Riel, J.K. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Mutagen sensitivity of Drosophila melanogaster. VI. Evidence from the excision-defective mei-9AT1 mutant for the timing of DNA-repair activity during spermatogenesis. Smith, P.D., Baumen, C.F., Dusenbery, R.L. Mutat. Res. (1983) [Pubmed]
  6. Drosophila MUS312 interacts with the nucleotide excision repair endonuclease MEI-9 to generate meiotic crossovers. Yildiz, O., Majumder, S., Kramer, B., Sekelsky, J.J. Mol. Cell (2002) [Pubmed]
  7. Mismatch repair, gene conversion, and crossing-over in two recombination-defective mutants of Drosophila melanogaster. Carpenter, A.T. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  8. Drosophila mutations at the mei-9 and mus(2)201 loci which block excision of thymine dimers also block induction of unscheduled DNA synthesis by methyl methanesulfonate, ethyl methanesulfonate, N-methyl-N-nitrosourea, UV light and X-rays. Dusenbery, R.L., McCormick, S.C., Smith, P.D. Mutat. Res. (1983) [Pubmed]
  9. DNA mismatch repair catalyzed by extracts of mitotic, postmitotic, and senescent Drosophila tissues and involvement of mei-9 gene function for full activity. Bhui-Kaur, A., Goodman, M.F., Tower, J. Mol. Cell. Biol. (1998) [Pubmed]
  10. Mutational analysis of the Drosophila DNA repair and recombination gene mei-9. Yildiz, O., Kearney, H., Kramer, B.C., Sekelsky, J.J. Genetics (2004) [Pubmed]
  11. Cytogenetic characterization of the 4BC region on the X chromosome of Drosophila melanogaster: localization of the mei-9, norpA and omb genes. Banga, S.S., Bloomquist, B.T., Brodberg, R.K., Pye, Q.N., Larrivee, D.C., Mason, J.M., Boyd, J.B., Pak, W.L. Chromosoma (1986) [Pubmed]
  12. Rapid screening of potential human bladder carcinogens: genotoxicity in meiosis repair deficient Drosophila melanogaster. Lamm, L.M., Reichert, D.F., Lamm, D.L. J. Urol. (1989) [Pubmed]
  13. Equivalence of UDS responses for established cell lines and primary cells derived from the mei-9a and mus201D1 excision repair-deficient strains of Drosophila melanogaster. Dusenbery, R.L., Lee-Chen, S.F. Mutat. Res. (1988) [Pubmed]
  14. Recovery and characterization of hybrid dysgenesis-induced mei-9 and mei-41 alleles of Drosophila melanogaster. Yamamoto, A.H., Brodberg, R.K., Banga, S.S., Boyd, J.B., Mason, J.M. Mutat. Res. (1990) [Pubmed]
  15. DNA repair dependence of somatic mutagenesis of transposon-caused white alleles in Drosophila melanogaster after treatment with alkylating agents. Fujikawa, K., Kondo, S. Genetics (1986) [Pubmed]
  16. 5-Azacytidine induces sex chromosome loss and interchange in immature germ cells of Drosophila mei-9 males. Osgood, C.J., Seward, S.M. Environ. Mol. Mutagen. (1989) [Pubmed]
  17. The repair-deficient mei-9 alpha Drosophila female potentiates chromosome loss induced in the parenteral genome by diethylnitrosamine. Zimmering, S., Hartmann, A.W., Song, A.S. Mutat. Res. (1981) [Pubmed]
  18. Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers. Radford, S.J., Goley, E., Baxter, K., McMahan, S., Sekelsky, J. Genetics (2005) [Pubmed]
  19. Postreplication repair-defective mutants of Drosophila melanogaster fall into two classes. Brown, T.C., Boyd, J.B. Mol. Gen. Genet. (1981) [Pubmed]
  20. Studies on mutagen sensitive strains of Drosophila melanogaster. XI. Survival (dominant lethality) after X-irradiation and relation to recessive lethals and translocations. Ferro, W., Eeken, J.C. Mutat. Res. (1993) [Pubmed]
  21. Recombination nodules and synaptonemal complex in recombination-defective females of Drosophila melanogaster. Carpenter, A.T. Chromosoma (1979) [Pubmed]
  22. Studies on mutagen-sensitive strains of Drosophila melanogaster. II. Detection of qualitative differences between genetic damage induced by X-irradiation of mature spermatozoa in oxygenated and anoxic atmospheres through the use of the repair-deficient mutant mei-9a. Ferro, W. Mutat. Res. (1983) [Pubmed]
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