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Gene Review

VWF  -  von Willebrand factor

Canis lupus familiaris

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Disease relevance of VWF


High impact information on VWF


Chemical compound and disease context of VWF


Biological context of VWF


Anatomical context of VWF

  • RESULTS: There were significantly more microvessels positive for VWF in the adventitia of skeletonized ITAs than in the adventitia of pedicled ITAs but the expression of PCNA in both groups was minimal, as in normal vessels. iNOS was not detected in any specimen [13].
  • Counts of von Willebrand factor-positive microvessels and smooth muscle alpha-actin-positive arterioles demonstrated that the angiogenesis and ateriogenesis was promoted in the laser group and correlated directly with the number of MMP-stained microvessels [14].
  • Immunofluorescent staining with antibodies to von Willebrand factor and ultrastructural analysis with an electron microscope confirmed the endothelial character of these cells lining the lumen of the skeletal muscle ventricles [15].
  • We determined whether administration of cryoprecipitate or fresh-frozen plasma (FFP) would enhance glass bead platelet retention and shorten the bleeding time in von Willebrand factor (vWf)-deficient Doberman Pinschers [16].
  • Constitutive release and intracellular content of vWf in cultured EC from femoral veins was about 30 times higher than that from femoral arterial EC, which was barely detectable [17].

Associations of VWF with chemical compounds


Other interactions of VWF


Analytical, diagnostic and therapeutic context of VWF


  1. Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor. De Meyer, S.F., Vanhoorelbeke, K., Chuah, M.K., Pareyn, I., Gillijns, V., Hebbel, R.P., Collen, D., Deckmyn, H., VandenDriessche, T. Blood (2006) [Pubmed]
  2. Aurintricarboxylic acid in a canine model of coronary artery thrombosis. Strony, J., Phillips, M., Brands, D., Moake, J., Adelman, B. Circulation (1990) [Pubmed]
  3. Influence of factor VIII/von Willebrand factor protein (F VIII/vWF) and F VIII/vWF-poor cryoprecipitate on post-ischemic microvascular reperfusion in the central nervous system. Hallenbeck, J.M., Furlow, T.W., Gralnick, H.R. Stroke (1981) [Pubmed]
  4. Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis. Hennan, J.K., Swillo, R.E., Morgan, G.A., Leik, C.E., Brooks, J.M., Shaw, G.D., Schaub, R.G., Crandall, D.L., Vlasuk, G.P. Thromb. Haemost. (2006) [Pubmed]
  5. Blockade of platelet membrane glycoprotein Ib receptors delays intracoronary thrombogenesis, enhances thrombolysis, and delays coronary artery reocclusion in dogs. Yao, S.K., Ober, J.C., Garfinkel, L.I., Hagay, Y., Ezov, N., Ferguson, J.J., Anderson, H.V., Panet, A., Gorecki, M., Buja, L.M. Circulation (1994) [Pubmed]
  6. Inherited platelet delta-storage pool disease in dogs causing severe bleeding: an animal model for a specific ADP deficiency. Callan, M.B., Bennett, J.S., Phillips, D.K., Haskins, M.E., Hayden, J.E., Anderson, J.G., Giger, U. Thromb. Haemost. (1995) [Pubmed]
  7. Evaluation of the buccal bleeding time and platelet glass bead retention as assays of hemostasis in the dog: the effects of acetylsalicylic acid, warfarin and von Willebrand factor deficiency. Brassard, J.A., Meyers, K.M. Thromb. Haemost. (1991) [Pubmed]
  8. Effect of desmopressin on von Willebrand factor multimers in Doberman Pinschers with type 1 von Willebrand disease. Callan, M.B., Giger, U., Catalfamo, J.L. Am. J. Vet. Res. (2005) [Pubmed]
  9. Plasma von Willebrand factor antigen concentration in dogs with hypothyroidism. Panciera, D.L., Johnson, G.S. J. Am. Vet. Med. Assoc. (1994) [Pubmed]
  10. DDAVP-induced increases in coagulation factor VIII and von Willebrand factor in the plasma of conscious dogs. Johnson, G.S., Kraus, K.H., Turrentine, M.A., Dean, P.W. J. Vet. Pharmacol. Ther. (1986) [Pubmed]
  11. False positive results in chimeraplasty for von Willebrand Disease. De Meyer, S.F., Pareyn, I., Baert, J., Deckmyn, H., Vanhoorelbeke, K. Thromb. Res. (2007) [Pubmed]
  12. Von Willebrand's disease in the German shepherd dog. Lobetti, R.G., Dippenaar, T. Journal of the South African Veterinary Association. (2000) [Pubmed]
  13. Does skeletonization compromise the integrity of internal thoracic artery grafts? Ueda, T., Taniguchi, S., Kawata, T., Mizuguchi, K., Nakajima, M., Yoshioka, A. Ann. Thorac. Surg. (2003) [Pubmed]
  14. Role of MMPs and plasminogen activators in angiogenesis after transmyocardial laser revascularization in dogs. Li, W., Tanaka, K., Chiba, Y., Kimura, T., Morioka, K., Uesaka, T., Ihaya, A., Sasaki, M., Tsuda, T., Yamada, N. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  15. Endothelial cell-lined skeletal muscle ventricles in circulation. Thomas, G.A., Lelkes, P.I., Isoda, S., Chick, D., Lu, H., Hammond, R.L., Nakajima, H., Nakajima, H., Walters, H.L., Stephenson, L.W. J. Thorac. Cardiovasc. Surg. (1995) [Pubmed]
  16. Effect of cryoprecipitate and plasma on plasma von Willebrand factor multimeters and bleeding time in Doberman Pinschers with type-I von Willebrand's disease. Ching, Y.N., Meyers, K.M., Brassard, J.A., Wardrop, K.J. Am. J. Vet. Res. (1994) [Pubmed]
  17. Differential distribution of von Willebrand factor in canine vascular endothelium. Smith, J.M., Meinkoth, J.H., Hochstatter, T., Meyers, K.M. Am. J. Vet. Res. (1996) [Pubmed]
  18. Conformational changes in von Willebrand's factor protein: effects on the binding of factor VIII-coagulant. Benson, R.E., Jones, D.W., Dodds, W.J. Am. J. Hematol. (1986) [Pubmed]
  19. Aurintricarboxylic acid prevents acute rethrombosis in a canine model of arterial thrombosis. Strony, J., Song, A., Rusterholtz, L., Adelman, B. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  20. Lack of gradual regulation of tetracycline-controlled gene expression by the tetracyclin-repressor/VP16 transactivator (tTA) in cultured cells. Hop, C., de Waard, V., van Mourik, J.A., Pannekoek, H. FEBS Lett. (1997) [Pubmed]
  21. V2 receptor antagonism of DDAVP-induced release of hemostasis factors in conscious dogs. Bernat, A., Hoffmann, P., Dumas, A., Serradeil-le Gal, C., Raufaste, D., Herbert, J.M. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  22. Localization of changes in beta-actin expression in remodeled canine myocardium. Tian, B., Carlyle, W.C., Weigold, W.G., McDonald, K.M., Judd, D.L., Toher, C.A., Homans, D.C., Cohn, J.N. J. Mol. Cell. Cardiol. (1999) [Pubmed]
  23. Immunohistochemical and histopathologic features of 14 malignant fibrous histiocytomas from Flat-Coated Retrievers. Morris, J.S., McInnes, E.F., Bostock, D.E., Hoather, T.M., Dobson, J.M. Vet. Pathol. (2002) [Pubmed]
  24. Coagulation activators and inhibitors in the neointima of polyester vascular grafts. Kowalewski, R., Zimnoch, L., Wojtukiewicz, M.Z., Glowinski, S., Glowinski, J. Blood Coagul. Fibrinolysis (2003) [Pubmed]
  25. The influence of preadsorbed canine von Willebrand factor, fibronectin and fibrinogen on ex vivo artificial surface-induced thrombosis. Lambrecht, L.K., Young, B.R., Stafford, R.E., Park, K., Albrecht, R.M., Mosher, D.F., Cooper, S.L. Thromb. Res. (1986) [Pubmed]
  26. Angiogenic effects of long-term enhanced external counterpulsation in a dog model of myocardial infarction. Wu, G., Du, Z., Hu, C., Zheng, Z., Zhan, C., Ma, H., Fang, D., Ahmed, K.T., Laham, R.J., Hui, J.C., Lawson, W.E. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  27. Differences in reendothelialization after balloon catheter removal of endothelial cells, superficial endarterectomy, and deep endarterectomy. Goff, S.G., Wu, H.D., Sauvage, L.R., Usui, Y., Wechezak, A.R., Coan, D.E., Arnell, R.E., Walker, M.W. J. Vasc. Surg. (1988) [Pubmed]
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