Disease relevance of LOC443392

• The purified lectin was specific for both T-antigen and N-acetyl-D-lactosamine, markers for various carcinomas, in addition to N-acetyl-D-galactosamine, asialofetuin and fetuin [1].

High impact information on LOC443392

• Compared to normals, lymphocytes from patients with chronic lymphatic leukemia demonstrate decreased fetuin glycopeptide binding with a mean of 0.9 x 10(6) sites per cell [2].
• Stepwise degradation of fetuin glycopeptide established the galactose residues as important determinants of inhibitory activity [2].
• Studies of the binding of [3H] fetuin glycopeptide to normal lymphocytes demonstrate 7.5 x 10(6) saturable binding sites per cell [2].
• Fetuin, a glycoprotein which binds MBHA, blocked the binding of 125I-MBHA to vegetative cells but not developmental cells [3].
• Fetuin positive cells predominated both in terms of the larger number of cells which stained at 35-40 days gestation and in the persistence of positive cells up to 125 days gestation [4].

Biological context of LOC443392

• A fetuin-related glycoprotein (alpha 2HS) in human embryonic and fetal development [5].
• A short 19 amino-acid sequence of fetuin shows a degree of homology to an 18 amino-acid sequence of the TGF-beta type II receptor (TbetaR-II) and in vitro fetuin binds to members of the TGF-beta family of cytokines [6].
• Only fetuin was able to inhibit the hemagglutination reactions [7].
• Tissue distribution and developmental expression of fetuin were studied in the sheep fetus from embryonic day (E) 30 to adult (gestational period is 150 days) [8].

Anatomical context of LOC443392

• The data suggest that fetuin glycopeptide inhibits rosette formation by binding to the thymus-dependent cell where competition occurs with sheep erythrocytes for specific lymphocyte surface receptors [2].
• TGF-beta receptor type II and fetuin in the developing sheep neocortex [6].
• Using three separate cellular markers: lysozyme, S-100, and alpha 1-antitrypsin, the cellular identification of fetuin-positive cells was confirmed to be in the monocyte/macrophage lineage [9].
• Immunohistochemical studies of human fetuses (6-33 weeks gestation) showed that alpha 2HS glycoprotein and fetuin have similar distributions in developing brain and several other tissues, e.g., bone, kidney, gonads, gastrointestinal tract, respiratory and cardiovascular systems [5].
• In the adult, fetuin mRNA was only detectable by northern blot in the liver and the bone marrow [9].

Associations of LOC443392 with chemical compounds

• Lactose and fetuin strongly inhibited the hemagglutinating activity [10].
• Two neuraminic acid specific lectins, Sambucus nigra and Maackia amurensis, labelled consistently the fetuin-positive cells as demonstrated by double labelling with lectins and antifetuin antibodies [11].
• The behavior of both types of labeled specimens of fetuin and ovine submaxillary mucin, individually and in mixtures, was investigated by gel-filtration chromatography, gel electrophoresis, and cesium bromide gradient ultracentrifugation [12].
• Assays for inhibition of hemagglutination were performed with alpha-D-fucose, alpha-D-galactose, beta-D-galactose, D-glucose, N-acetyl-galactosamine, N-acetyl-glucosamine, N-acetylneuraminic acid, N-acetylneuraminic acid-lactose, and fetuin [7].
• Only L-arginine, L-lysine (100 mM), mucin, and fetuin (1 mg/ml) partially inhibited the haemagglutination with native bacterial cells but completely inhibited that with heated cells, whereas none was inhibitory in the reaction with trypsin-treated cells [13].

Other interactions of LOC443392

• The three primary embryonic layers and tissues that differentiate from them were tested for the presence of alpha-fetoprotein (AFP), fetuin, albumin, transferrin and alpha 1-antitrypsin using the indirect immunoperoxidase method [14].

Analytical, diagnostic and therapeutic context of LOC443392

• 3. At 35 days gestation fetuin and albumin were quantitatively the most important proteins in fetal brain, both as estimated by extraction and by immunohistochemistry [4].
• Using in situ hybridization in adult tissue, fetuin mRNA-positive cells were identified in the bone marrow to be monocytes/macrophages [9].

References