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Gene Review

lds  -  lodestar

Drosophila melanogaster

Synonyms: CG2684, DmF2, Dmel\CG2684, Fs(3)Hor, Fs(3)Horka, ...
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High impact information on lds

  • Prevalence is estimated to be as high as 1 in 10,000 (ref. 4). We carried out genome-wide linkage exclusion analysis in 12 families with CdLS and identified four candidate regions, of which chromosome 5p13.1 gave the highest multipoint lod score of 2 [1].
  • Using a genome-wide screen in four JP kindreds without germline mutations in MADH4 or PTEN, we identified linkage with markers from chromosome 10q22-23 (maximum lod score of 4.74, straight theta=0.00) [2].
  • Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein [3].
  • Here we report the cloning, DNA sequence, genomic structure, ecdysone inducibility, and temporal expression of an early gene residing in the 23E early puff and denoted E23 (Early gene at 23) [4].
  • E47 is a widely expressed transcription factor that activates B-cell-specific immunoglobulin gene transcription and is required for early B-cell development [5].

Biological context of lds


Anatomical context of lds


Associations of lds with chemical compounds

  • We show here that the transcript release activity of factor 2 requires ATP or dATP and that adenosine 5'-O-(thiotriphosphate) (ATPgammaS), adenosine 5'-(beta,gamma-imino)triphosphate (AMP-PNP), or other NTPs do not support the activity [12].
  • We combined these promoters with either a short, double poly-adenylation site derived from the Heliothis virescens p63 chaperonin gene, or with a fusion of the small t intron with the early 3' untranslated region and poly-adenylation sites of SV40 [13].
  • Evidence for an Early Gene Duplication Event in the Evolution of the Mitochondrial Transcription Factor B Family and Maintenance of rRNA Methyltransferase Activity in Human mtTFB1 and mtTFB2 [14].

Other interactions of lds


Analytical, diagnostic and therapeutic context of lds


  1. Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B. Krantz, I.D., McCallum, J., DeScipio, C., Kaur, M., Gillis, L.A., Yaeger, D., Jukofsky, L., Wasserman, N., Bottani, A., Morris, C.A., Nowaczyk, M.J., Toriello, H., Bamshad, M.J., Carey, J.C., Rappaport, E., Kawauchi, S., Lander, A.D., Calof, A.L., Li, H.H., Devoto, M., Jackson, L.G. Nat. Genet. (2004) [Pubmed]
  2. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Howe, J.R., Bair, J.L., Sayed, M.G., Anderson, M.E., Mitros, F.A., Petersen, G.M., Velculescu, V.E., Traverso, G., Vogelstein, B. Nat. Genet. (2001) [Pubmed]
  3. Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein. Girdham, C.H., Glover, D.M. Genes Dev. (1991) [Pubmed]
  4. The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation. Hock, T., Cottrill, T., Keegan, J., Garza, D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Notch inhibition of E47 supports the existence of a novel signaling pathway. Ordentlich, P., Lin, A., Shen, C.P., Blaumueller, C., Matsuno, K., Artavanis-Tsakonas, S., Kadesch, T. Mol. Cell. Biol. (1998) [Pubmed]
  6. Horka, a dominant mutation of Drosophila, induces nondisjunction and, through paternal effect, chromosome loss and genetic mosaics. Szabad, J., Máthé, E., Puro, J. Genetics (1995) [Pubmed]
  7. Transcription of Drosophila troponin I gene is regulated by two conserved, functionally identical, synergistic elements. Marín, M.C., Rodríguez, J.R., Ferrús, A. Mol. Biol. Cell (2004) [Pubmed]
  8. Transcription of Myocyte enhancer factor-2 in adult Drosophila myoblasts is induced by the steroid hormone ecdysone. Lovato, T.L., Benjamin, A.R., Cripps, R.M. Dev. Biol. (2005) [Pubmed]
  9. Independent regulatory elements in the upstream region of the Drosophila beta 3 tubulin gene (beta Tub60D) guide expression in the dorsal vessel and the somatic muscles. Damm, C., Wolk, A., Buttgereit, D., Löher, K., Wagner, E., Lilly, B., Olson, E.N., Hasenpusch-Theil, K., Renkawitz-Pohl, R. Dev. Biol. (1998) [Pubmed]
  10. The COE--Collier/Olf1/EBF--transcription factors: structural conservation and diversity of developmental functions. Dubois, L., Vincent, A. Mech. Dev. (2001) [Pubmed]
  11. Cytology of aberrations induced by x-rays in oocytes of Drosophila melanogaster. II. Early meiotic stages. Savontaus, M.L. Hereditas (1981) [Pubmed]
  12. Drosophila factor 2, an RNA polymerase II transcript release factor, has DNA-dependent ATPase activity. Xie, Z., Price, D. J. Biol. Chem. (1997) [Pubmed]
  13. Construction of modular and versatile plasmid vectors for the high-level expression of single or multiple genes in insects and insect cell lines. Huynh, C.Q., Zieler, H. J. Mol. Biol. (1999) [Pubmed]
  14. Evidence for an Early Gene Duplication Event in the Evolution of the Mitochondrial Transcription Factor B Family and Maintenance of rRNA Methyltransferase Activity in Human mtTFB1 and mtTFB2. Cotney, J., Shadel, G.S. J. Mol. Evol. (2006) [Pubmed]
  15. Unusual nucleic acid binding properties of factor 2, an RNA polymerase II transcript release factor. Xie, Z., Price, D.H. J. Biol. Chem. (1998) [Pubmed]
  16. Collier, a novel regulator of Drosophila head development, is expressed in a single mitotic domain. Crozatier, M., Valle, D., Dubois, L., Ibnsouda, S., Vincent, A. Curr. Biol. (1996) [Pubmed]
  17. Involvement of EDTP, an Egg-Derived Tyrosine Phosphatase, in the Early Development of Drosophila melanogaster. Yamaguchi, S., Katagiri, S., Sekimizu, K., Natori, S., Homma, K.J. J. Biochem. (2005) [Pubmed]
  18. Characterization and purification of Adh distal promoter factor 2, Adf-2, a cell-specific and promoter-specific repressor in Drosophila. Benyajati, C., Ewel, A., McKeon, J., Chovav, M., Juan, E. Nucleic Acids Res. (1992) [Pubmed]
  19. Purification of an RNA polymerase II transcript release factor from Drosophila. Xie, Z., Price, D.H. J. Biol. Chem. (1996) [Pubmed]
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