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Gene Review

NDUFB4  -  NADH dehydrogenase (ubiquinone) 1 beta...

Homo sapiens

Synonyms: B15, CI-B15, Complex I-B15, NADH-ubiquinone oxidoreductase B15 subunit
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Disease relevance of NDUFB4

  • Samples of 21 patients with CML, the ALL-derived cell line SUP-B15, and of seven patients with Philadelphia chromosome (Ph1)-positive ALL (three of them with breakpoints within m-bcr) were examined [1].
  • Identification and characterization of a novel insertion sequence, IS1106, downstream of the porA gene in B15 Neisseria meningitidis [2].
  • Human leucocyte antigen B15 tended to occur more frequently in patients with malignant and non-malignant hypertension than in control subjects, especially if a family history of hypertension was taken into consideration [3].
  • The strong association of MCTD to one DR4 subtype was further seen in the significantly increased frequency of the B15, DR4 combination [4].
  • The supernatant from the Tr2D8 (EBV line X KR4) hybridoma (2.7 micrograms IgM/ml) only lysed B15 bearing PBMC [5].

Psychiatry related information on NDUFB4

  • Nonetheless, Blankenberger (Cognition 82 (2001) B15) eliminated the tie response time (RT) advantage by presenting problems in mixed formats (e.g. 4 x four), which suggests that the tie effect with homogenous formats (4 x 4 or four x four) is due to encoding [6].

High impact information on NDUFB4

  • Brain and heart transcripts of the DM-kinase (DMR-B15) gene are subject to alternative RNA splicing in both human and mouse [7].
  • B2/B2 embryos (the B locus is the major histocompatibility locus of chickens) were more sensitive to lesion formation than were B15/B21 and outbred embryos; this suggested a genetic influence on lesion formation [8].
  • The HLA phenotype of the patient's skin fibroblasts [A3, Bw44 (w4)/A2, B15 (w4)] was appropriate for parental haplotypes and probably represented her true HLA phenotype [9].
  • The most reactive site in subunit B14 was Tyr122, while the most reactive region in B15 contained 3 closely spaced tyrosines Tyr46, Tyr50, and Tyr51 [10].
  • On removal of IL-3, Bo cells underwent apoptosis within 8 h, whereas B14 and B15 cells were resistant for at least 24 h [11].

Biological context of NDUFB4

  • Moreover, we found that this second diabetogenic gene is associated primarily with B15 and only secondarily with Cw3, which is in linkage disequilibrium with B15 [12].
  • B14 and B15 cells became glycolytically arrested but maintained stable ATP levels during protection from apoptosis [11].
  • Characterization of a copy of this repetitive sequence present in B15 strains has revealed the presence of a novel insertion sequence (IS1106) located within a complex repetitive region downstream of the gene for the major surface antigen (porA) [2].
  • The hydrolysis time for which maximal Feulgen-DNA values are attained also differs when comparing the hetero- and euchromatic regions of the C chromosome and the heterochromatic regions C11 and B15 to each other [13].
  • The furoxan derivatives of aspirin (B8, B7) and their NO-free furazan equivalents (B16, B15; all 100 microM) significantly inhibited COX activity (P < 0.01; n = 6) in vitro and caused aspirin-independent, cGMP-dependent inhibition of collagen-induced platelet aggregation in WP [14].

Anatomical context of NDUFB4

  • Recognition of the immunodominant epitope was restricted by human leukocyte antigen (HLA) B15, and recognition of all the others was by HLA A2 [15].
  • An analysis of profiles of Feulgen hydrolysis curves has been carried out in two heterochromatic (B-15 and C-11) and one euchromatic (C-1) regions of polytene chromosomes of salivary glands of 66 day old Rhynchosciara americana larvae [13].
  • Similarly, the CD8+ T-cell clone specific to GAD65(277-285) killed peptide-sensitized target cells expressing HLA B35 and B15 [16].
  • Cells expressing HLA molecules in the B15 family were identified by serologic typing in routine testing of volunteer donors of various ethnic backgrounds for a bone marrow registry [17].
  • These results suggest that acupuncture in the specific meridian points may have sites specific regulatory function for the hormone levels and that the meridian points, B23 and B15, may have control mechanism for the regulation in the body fluid and electrolytes balance [18].

Associations of NDUFB4 with chemical compounds

  • Furthermore, we tested three natural subtypes of HLA-B15, and found that a B15 subtype with a tyrosine at position 116 (B*1510) was strongly associated not only with TAP, but also with tapasin and calreticulin [19].
  • In contrast, two B15 subtypes with a serine at position 116 (B*1518 and B*1501) exhibited very little or no association with any of these proteins [19].
  • Treatment with 10 microM clotrimazole (a concentration achievable in vivo) reduced cell recovery from cultures of all nine ALL cell lines studied (B-lineage: OP-1, SUP-B15, RS4;11, NALM6, REH, and 380; T-lineage: MOLT4, CCRF-CEM, and CEM-C7) [20].
  • By a series of sequential immuno-precipitation experiments, Y was shown to be a "public" antigenic determinant distinct from the "private" determinants B5, B15, B18, and Bw35, but present on the same 44,000 dalton glycoprotein molecules [21].
  • Examination of HLA, Bf and C4 phenotypes suggested that at least two supratypes "B15 BfS C4A3B3 D(R)4" and "B8 BfS C4A0B1 D(R)3" were markers for the susceptibility to type I diabetes, one third of our patients had either of these supratypes [22].

Analytical, diagnostic and therapeutic context of NDUFB4

  • Comparative peptide mapping of these B15 allotypes further pinpoints endogenously processed ligands that bind to the allotypes B*1508, B*1501, and B*1503, but not B*1510 [23].
  • Interestingly, when their surface expression was tested by flow cytometry, the HLA-B15 subtypes with little to no detectable intracellular assembly complex association had a slightly, yet consistently, higher level of the open heavy chain form than did the B15 subtype with intracellular assembly complex association [19].
  • Molecular DNA class I typing approaches are also swayed by genetic recombinations to type B*1304 as a B15 molecule: B15-like nucleotide sequences encoding residues 114, 116, and 145, lead B*1304 to exhibit a B15 PCR amplification pattern [24].
  • Generation of the HLA-B35, -B5, -B16, and B15 groups of alleles studied by intron 1 and 2 sequence analysis [25].
  • Using microcytotoxicity testing, a fluoresceinated Protein A binding assay, and chemical immunoprecipitation techniques, we have defined a new public alloantigenic determinant, tentatively designated "Z," which is present on the 44,000 dalton glycoprotein chains of HLA-B15 and HLA-B17, but distinct from the B15 and B17 determinants [26].


  1. Detection of chimeric BCR-ABL genes on bone marrow samples and blood smears in chronic myeloid and acute lymphoblastic leukemia by in situ hybridization. Bentz, M., Cabot, G., Moos, M., Speicher, M.R., Ganser, A., Lichter, P., Döhner, H. Blood (1994) [Pubmed]
  2. Identification and characterization of a novel insertion sequence, IS1106, downstream of the porA gene in B15 Neisseria meningitidis. Knight, A.I., Ni, H., Cartwright, K.A., McFadden, J.J. Mol. Microbiol. (1992) [Pubmed]
  3. Abnormal immune function in malignant hypertension. Hilme, E., Hansson, L., Sandberg, L., Söderström, T., Herlitz, H. J. Hypertens. (1993) [Pubmed]
  4. Differences in HLA antigens between patients with mixed connective tissue disease and systemic lupus erythematosus. Ruuska, P., Hämeenkorpi, R., Forsberg, S., Julkunen, H., Mäkitalo, R., Ilonen, J., Tiilikainen, A. Ann. Rheum. Dis. (1992) [Pubmed]
  5. A human-human hybridoma producing cytotoxic antibody to HLA-B15, cross-reacting with B17, B5, B35 and B18. Hansen, T., Kolstad, A., Thorsby, E., Hannestad, K. Tissue Antigens (1987) [Pubmed]
  6. Calculation, culture, and the repeated operand effect. Campbell, J.I., Gunter, R. Cognition. (2002) [Pubmed]
  7. Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs. Jansen, G., Mahadevan, M., Amemiya, C., Wormskamp, N., Segers, B., Hendriks, W., O'Hoy, K., Baird, S., Sabourin, L., Lennon, G. Nat. Genet. (1992) [Pubmed]
  8. A new class of infectious agents detectable by the production of chorioallantoic membrane lesions by human lymphoblastoid cell lines and their culture supernatants. Longenecker, B.M., Menezes, J., Sanders, E.J., Pazderka, F., Ruth, R.F. J. Natl. Cancer Inst. (1977) [Pubmed]
  9. Fatal graft-versus-host disease following blood transfusion in Hodgkin's disease documented by HLA typing. Dinsmore, R.E., Straus, D.J., Pollack, M.S., Woodruff, J.M., Garrett, T.J., Young, C.W., Clarkson, B.D., Dupont, B. Blood (1980) [Pubmed]
  10. Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry. Murray, J., Taylor, S.W., Zhang, B., Ghosh, S.S., Capaldi, R.A. J. Biol. Chem. (2003) [Pubmed]
  11. Energy metabolism during apoptosis. Bcl-2 promotes survival in hematopoietic cells induced to apoptose by growth factor withdrawal by stabilizing a form of metabolic arrest. Garland, J.M., Halestrap, A. J. Biol. Chem. (1997) [Pubmed]
  12. HLA-D--related (DRw) antigens in juvenile diabetes mellitus. Farid, N.R., Sampson, L., Noel, P., Barnard, J.M., Davis, A.J., Hillman, D.A. Diabetes (1979) [Pubmed]
  13. Acid lability of deoxyribonucleic acids of some polytene chromosome regions of Rhynchosciara americana. Mello, M.L., Vidal, B.C. Chromosoma (1980) [Pubmed]
  14. Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets. Turnbull, C.M., Cena, C., Fruttero, R., Gasco, A., Rossi, A.G., Megson, I.L. Br. J. Pharmacol. (2006) [Pubmed]
  15. Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. Parker, C.E., Nightingale, S., Taylor, G.P., Weber, J., Bangham, C.R. J. Virol. (1994) [Pubmed]
  16. CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility. Ou, D., Jonsen, L.A., Metzger, D.L., Tingle, A.J. Hum. Immunol. (1999) [Pubmed]
  17. HLA-B alleles associated with the B15 serologically defined antigens. Steiner, N., Ng, J., Bush, J., Hartzman, R.J., Johnston-Dow, L., Hurley, C.K. Hum. Immunol. (1997) [Pubmed]
  18. Effects of acupuncture on the plasma atrial natriuretic peptide. Aldosterone and renin activity in man. Lee, H.S., Song, J.C., Kim, K.S. Acupuncture & electro-therapeutics research. (1991) [Pubmed]
  19. HLA-B polymorphism affects interactions with multiple endoplasmic reticulum proteins. Turnquist, H.R., Thomas, H.J., Prilliman, K.R., Lutz, C.T., Hildebrand, W.H., Solheim, J.C. Eur. J. Immunol. (2000) [Pubmed]
  20. The antifungal antibiotic clotrimazole alters calcium homeostasis of leukemic lymphoblasts and induces apoptosis. Ito, C., Tecchio, C., Coustan-Smith, E., Suzuki, T., Behm, F.G., Raimondi, S.C., Pui, C.H., Campana, D. Leukemia (2002) [Pubmed]
  21. A public antigenic determinant in the HLA-B5 cross-reacting group--a basis for cross-reactivity and a possible link with Behcet's disease. Schwartz, B.D., Luehrman, L.K., Lee, J., Rodey, G.E. Hum. Immunol. (1980) [Pubmed]
  22. HLA antigens and complotypes in insulin-dependent diabetes mellitus. Partanen, J., Koskimies, S., Ilonen, J., Knip, M. Tissue Antigens (1986) [Pubmed]
  23. HLA-B15 peptide ligands are preferentially anchored at their C termini. Prilliman, K.R., Jackson, K.W., Lindsey, M., Wang, J., Crawford, D., Hildebrand, W.H. J. Immunol. (1999) [Pubmed]
  24. Polymorphism at codons 114, 116, 145, and 163 muddle the typing of HLA-B*1304. Ellexson, M., Lai-Kwan, P., Lau, M., Muto, K., Terasaki, P., Cole, J., Thompson, C., Hildebrand, W. Hum. Immunol. (1997) [Pubmed]
  25. Generation of the HLA-B35, -B5, -B16, and B15 groups of alleles studied by intron 1 and 2 sequence analysis. Gómez-Casado, E., Vargas-Alarcón, G., Martinez-Laso, J., Perez-Blas, M., Granados, J., Layrisse, Z., Montoya, F., Varela, P., Arnaiz-Villena, A. Immunogenetics (1997) [Pubmed]
  26. HLA serological cross-reactivity: HLA-B15 has two public antigens. Schwartz, B.D., Luehrman, L.K., Lee, T., Rodey, G.E. Hum. Immunol. (1980) [Pubmed]
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