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Gene Review

HOXA10  -  homeobox A10

Homo sapiens

Synonyms: HOX1, HOX1.8, HOX1H, Homeobox protein Hox-1.8, Homeobox protein Hox-1H, ...
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Disease relevance of HOXA10


High impact information on HOXA10

  • In contrast, Hoxa10 and Hoxa11 induced morphogenesis of endometrioid-like and mucinous-like EOCs, respectively [6].
  • This coincides spatially and temporally with expression of maternal Hoxa10 in distal oviductal and uterine epithelium [7].
  • Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice [7].
  • In addition, non-tissue-specific protein-promoter interactions involving the Sp1 transcription factor are necessary for hPL transcription initiation [8].
  • The hPL enhancer is bound by multiple proteins including at least one placental specific protein that interacts with a TEF-1 motif [8].

Chemical compound and disease context of HOXA10


Biological context of HOXA10


Anatomical context of HOXA10

  • To explore if these patterns reflect different functional activities, we have retrovirally engineered the overexpression of a 5'-located gene, HOXA10, in murine bone marrow cells and demonstrate effects strikingly different from those induced by overexpression of a 3'-located gene, HOXB4 [15].
  • We have analyzed the expression of homeoproteins of the HOX family in resting and activated lymphoid cells and in neoplastic lymphoid cell lines by the use of monoclonal antibodies (MoAbs) already shown to react with the homeoproteins HOXA10, HOXC6, and HOXD4, respectively [16].
  • Here we demonstrate the expression of Pbx and Meis family cofactors in the human endometrium and their interaction with HOXA10 [13].
  • We have recently demonstrated that HOXA10 is expressed in the adult human uterus [17].
  • Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells [18].

Associations of HOXA10 with chemical compounds


Physical interactions of HOXA10


Regulatory relationships of HOXA10


Other interactions of HOXA10

  • Finally, our observation also supports the previous suggested role of HOXA10 and HOXA11 in normal thymocyte development [2].
  • When FKHR and HOXA10 are expressed together, promoter activity is markedly up-regulated, which is indicative of cooperativity [14].
  • Herein, we took advantage of the strong transforming potential of NUP98-HOXD13 or NUP98-HOXA10 to establish preleukemic myeloid lines from bone marrow cells that faithfully replicate the first step of Hox-induced leukemogenesis [22].
  • Real time quantitative PCR analysis for all HOXA genes revealed high levels of HOXA10 and HOXA11 expression in all inv(7) positive cases [2].
  • HOXA10, a homeobox transcription factor, is important in the decidualization process [14].

Analytical, diagnostic and therapeutic context of HOXA10


  1. Thrombin and interleukin-1beta regulate HOXA10 expression in human term decidual cells: implications for preterm labor. Sarno, J.L., Schatz, F., Lockwood, C.J., Huang, S.T., Taylor, H.S. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  2. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Speleman, F., Cauwelier, B., Dastugue, N., Cools, J., Verhasselt, B., Poppe, B., Van Roy, N., Vandesompele, J., Graux, C., Uyttebroeck, A., Boogaerts, M., De Moerloose, B., Benoit, Y., Selleslag, D., Billiet, J., Robert, A., Huguet, F., Vandenberghe, P., De Paepe, A., Marynen, P., Hagemeijer, A. Leukemia (2005) [Pubmed]
  3. Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Buske, C., Feuring-Buske, M., Antonchuk, J., Rosten, P., Hogge, D.E., Eaves, C.J., Humphries, R.K. Blood (2001) [Pubmed]
  4. Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: role in epithelial-mesenchymal transition. Yoshida, H., Broaddus, R., Cheng, W., Xie, S., Naora, H. Cancer Res. (2006) [Pubmed]
  5. EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis. Daftary, G.S., Taylor, H.S. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  6. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Cheng, W., Liu, J., Yoshida, H., Rosen, D., Naora, H. Nat. Med. (2005) [Pubmed]
  7. Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Satokata, I., Benson, G., Maas, R. Nature (1995) [Pubmed]
  8. The human placental lactogen genes: structure, function, evolution and transcriptional regulation. Walker, W.H., Fitzpatrick, S.L., Barrera-Saldaña, H.A., Resendez-Perez, D., Saunders, G.F. Endocr. Rev. (1991) [Pubmed]
  9. Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy. Epperly, M.W., Gretton, J.A., DeFilippi, S.J., Greenberger, J.S., Sikora, C.A., Liggitt, D., Koe, G. Radiat. Res. (2001) [Pubmed]
  10. Regulation of HOXA-10 and its expression in normal and abnormal endometrium. Gui, Y., Zhang, J., Yuan, L., Lessey, B.A. Mol. Hum. Reprod. (1999) [Pubmed]
  11. Effect of EGFR antagonists gefitinib (Iressa) and C225 (Cetuximab) on MnSOD-plasmid liposome transgene radiosensitization of a murine squamous cell carcinoma cell line. Epperly, M.W., Franicola, D., Zhang, X., Nie, S., Greenberger, J.S. In Vivo (2006) [Pubmed]
  12. Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10. Troy, P.J., Daftary, G.S., Bagot, C.N., Taylor, H.S. Mol. Cell. Biol. (2003) [Pubmed]
  13. HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric complexes on HOXA10 target genes. Sarno, J.L., Kliman, H.J., Taylor, H.S. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  14. Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells. Kim, J.J., Taylor, H.S., Akbas, G.E., Foucher, I., Trembleau, A., Jaffe, R.C., Fazleabas, A.T., Unterman, T.G. Biol. Reprod. (2003) [Pubmed]
  15. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Thorsteinsdottir, U., Sauvageau, G., Hough, M.R., Dragowska, W., Lansdorp, P.M., Lawrence, H.J., Largman, C., Humphries, R.K. Mol. Cell. Biol. (1997) [Pubmed]
  16. Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes. Meazza, R., Faiella, A., Corsetti, M.T., Airoldi, I., Ferrini, S., Boncinelli, E., Corte, G. Blood (1995) [Pubmed]
  17. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. Taylor, H.S., Arici, A., Olive, D., Igarashi, P. J. Clin. Invest. (1998) [Pubmed]
  18. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Du, H., Daftary, G.S., Lalwani, S.I., Taylor, H.S. Mol. Endocrinol. (2005) [Pubmed]
  19. Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. Daftary, G.S., Troy, P.J., Bagot, C.N., Young, S.L., Taylor, H.S. Mol. Endocrinol. (2002) [Pubmed]
  20. HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells. Chu, M.C., Selam, F.B., Taylor, H.S. Cancer Biol. Ther. (2004) [Pubmed]
  21. Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. Lawrence, H.J., Sauvageau, G., Ahmadi, N., Lopez, A.R., LeBeau, M.M., Link, M., Humphries, K., Largman, C. Exp. Hematol. (1995) [Pubmed]
  22. Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA. Pineault, N., Abramovich, C., Humphries, R.K. Leukemia (2005) [Pubmed]
  23. Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10. Björnsson, J.M., Andersson, E., Lundström, P., Larsson, N., Xu, X., Repetowska, E., Humphries, R.K., Karlsson, S. Blood (2001) [Pubmed]
  24. In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing müllerian system. Block, K., Kardana, A., Igarashi, P., Taylor, H.S. FASEB J. (2000) [Pubmed]
  25. Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression. Daftary, G.S., Taylor, H.S. Fertil. Steril. (2002) [Pubmed]
  26. Differentiation of endometrial stromal cells in vitro: down-regulation of suppression of the cell cycle inhibitor p57 by HOXA10? Qian, K., Chen, H., Wei, Y., Hu, J., Zhu, G. Mol. Hum. Reprod. (2005) [Pubmed]
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