Gene Review:
HOXA9 - homeobox A9
Homo sapiens
Synonyms:
ABD-B, HOX1, HOX1.7, HOX1G, Homeobox protein Hox-1G, ...
Barbouti,
Shen,
Nishii,
Fong,
Shiku,
Johansson,
Lawrence,
Kawakami,
Nilsson,
Reinhardt,
Höglund,
Fischbach,
Murata,
Mitelman,
Macleod,
Chrobak,
Quentmeier,
Largman,
Zaborski,
Le Beau,
Pang,
Lassen,
Fioretos,
Shinsato,
Rozenfeld,
Ginzinger,
Miyanishi,
Dirks,
Drexler,
Usui,
Kogan,
Kwong,
Hagemeijer,
Radhakrishnan,
- Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. Iwasaki, M., Kuwata, T., Yamazaki, Y., Jenkins, N.A., Copeland, N.G., Osato, M., Ito, Y., Kroon, E., Sauvageau, G., Nakamura, T. Blood (2005)
- HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. Shen, W.F., Rozenfeld, S., Kwong, A., Köm ves, L.G., Lawrence, H.J., Largman, C. Mol. Cell. Biol. (1999)
- A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). Barbouti, A., Höglund, M., Johansson, B., Lassen, C., Nilsson, P.G., Hagemeijer, A., Mitelman, F., Fioretos, T. Cancer Res. (2003)
- Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation. Chung, K.Y., Morrone, G., Schuringa, J.J., Plasilova, M., Shieh, J.H., Zhang, Y., Zhou, P., Moore, M.A. Cancer Res. (2006)
- A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Dash, A.B., Williams, I.R., Kutok, J.L., Tomasson, M.H., Anastasiadou, E., Lindahl, K., Li, S., Van Etten, R.A., Borrow, J., Housman, D., Druker, B., Gilliland, D.G. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nakamura, T., Largaespada, D.A., Lee, M.P., Johnson, L.A., Ohyashiki, K., Toyama, K., Chen, S.J., Willman, C.L., Chen, I.M., Feinberg, A.P., Jenkins, N.A., Copeland, N.G., Shaughnessy, J.D. Nat. Genet. (1996)
- The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Borrow, J., Shearman, A.M., Stanton, V.P., Becher, R., Collins, T., Williams, A.J., Dubé, I., Katz, F., Kwong, Y.L., Morris, C., Ohyashiki, K., Toyama, K., Rowley, J., Housman, D.E. Nat. Genet. (1996)
- Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Ayton, P.M., Cleary, M.L. Genes Dev. (2003)
- Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells. Kirito, K., Fox, N., Kaushansky, K. Mol. Cell. Biol. (2004)
- Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells. Fiskus, W., Pranpat, M., Balasis, M., Herger, B., Rao, R., Chinnaiyan, A., Atadja, P., Bhalla, K. Mol. Cancer Ther. (2006)
- Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Lawrence, H.J., Helgason, C.D., Sauvageau, G., Fong, S., Izon, D.J., Humphries, R.K., Largman, C. Blood (1997)
- The oncogene Nup98-HOXA9 induces gene transcription in myeloid cells. Ghannam, G., Takeda, A., Camarata, T., Moore, M.A., Viale, A., Yaseen, N.R. J. Biol. Chem. (2004)
- Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia. Casas, S., Nagy, B., Elonen, E., Aventín, A., Larramendy, M.L., Sierra, J., Ruutu, T., Knuutila, S. Leuk. Lymphoma (2003)
- Expression of HOX genes in acute leukemia cell lines with and without MLL translocations. Quentmeier, H., Dirks, W.G., Macleod, R.A., Reinhardt, J., Zaborski, M., Drexler, H.G. Leuk. Lymphoma (2004)
- In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing müllerian system. Block, K., Kardana, A., Igarashi, P., Taylor, H.S. FASEB J. (2000)
- Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. Sindt, A., Deau, B., Brahim, W., Staal, A., Visanica, S., Villarese, P., Rault, J.P., Macintyre, E., Delabesse, E. Genes Chromosomes Cancer (2006)
- Cdx4 and menin co-regulate hoxa9 expression in hematopoietic cells. Yan, J., Chen, Y.X., Desmond, A., Silva, A., Yang, Y., Wang, H., Hua, X. PLoS ONE (2006)
- Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells. Buettner, R., Yim, S.O., Hong, Y.S., Boncinelli, E., Tainsky, M.A. Mol. Cell. Biol. (1991)
- CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Kasper, L.H., Brindle, P.K., Schnabel, C.A., Pritchard, C.E., Cleary, M.L., van Deursen, J.M. Mol. Cell. Biol. (1999)
- TGFbeta/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability. Wang, N., Kim, H.G., Cotta, C.V., Wan, M., Tang, Y., Klug, C.A., Cao, X. EMBO J. (2006)
- Hoxa-9 represses transforming growth factor-beta-induced osteopontin gene transcription. Shi, X., Bai, S., Li, L., Cao, X. J. Biol. Chem. (2001)
- Evidence that the Pim1 kinase gene is a direct target of HOXA9. Hu, Y.L., Passegué, E., Fong, S., Largman, C., Lawrence, H.J. Blood (2007)
- Synergistic action of MLL, a TRX protein with template activating factor-I, a histone chaperone. Shimoyama, T., Kato, K., Miyaji-Yamaguchi, M., Nagata, K. FEBS Lett. (2005)
- MEIS1 and HOXA7 genes in human acute myeloid leukemia. Afonja, O., Smith, J.E., Cheng, D.M., Goldenberg, A.S., Amorosi, E., Shimamoto, T., Nakamura, S., Ohyashiki, K., Ohyashiki, J., Toyama, K., Takeshita, K. Leuk. Res. (2000)
- Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. Reynolds, P.A., Sigaroudinia, M., Zardo, G., Wilson, M.B., Benton, G.M., Miller, C.J., Hong, C., Fridlyand, J., Costello, J.F., Tlsty, T.D. J. Biol. Chem. (2006)
- Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels. Topisirovic, I., Kentsis, A., Perez, J.M., Guzman, M.L., Jordan, C.T., Borden, K.L. Mol. Cell. Biol. (2005)
- HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Fischbach, N.A., Rozenfeld, S., Shen, W., Fong, S., Chrobak, D., Ginzinger, D., Kogan, S.C., Radhakrishnan, A., Le Beau, M.M., Largman, C., Lawrence, H.J. Blood (2005)
- HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells. Bandyopadhyay, S., Ashraf, M.Z., Daher, P., Howe, P.H., DiCorleto, P.E. Mol. Cell. Biol. (2007)
- Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). Fujino, T., Suzuki, A., Ito, Y., Ohyashiki, K., Hatano, Y., Miura, I., Nakamura, T. Blood (2002)
- Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias. Lawrence, H.J., Rozenfeld, S., Cruz, C., Matsukuma, K., Kwong, A., Kömüves, L., Buchberg, A.M., Largman, C. Leukemia (1999)
- A case of acute myeloid leukemia with t(7;11)(p15;p15) mimicking myeloid crisis of chronic myelogenous leukemia. Kawakami, K., Miyanishi, S., Nishii, K., Usui, E., Murata, T., Shinsato, I., Shiku, H. Int. J. Hematol. (2002)
- Low frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia. Kwong, Y.L., Pang, A. Genes Chromosomes Cancer (1999)