The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

NTF3  -  neurotrophin 3

Felis catus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of NTF3

 

Psychiatry related information on NTF3

  • NT-3 mRNA is first detectable in small stellate neurons at the base of layer 4 (4c) after eye opening, and levels decrease near the end of the critical period [3].
  • We therefore determined whether cholinergic neurons in the latero-dorsal and pedunculo-pontine tegmental (LDT and PPT) nuclei, which are involved in the initiation of REM sleep and project to the NPO, contained NT-3 [4].
 

High impact information on NTF3

 

Chemical compound and disease context of NTF3

 

Biological context of NTF3

  • BDNF and NT-3 mRNAs are dynamically regulated in many CNS structures during embryonic and postnatal development, and both mRNAs undergo striking developmental changes in laminar specificity and levels of expression within primary visual cortex during the critical period for ocular dominance column formation [3].
  • The effects of neurotrophin-3 (NT-3) and NT-4/5 on the function of axotomized group Ia afferents and motoneurons comprising the monosynaptic reflex pathway were investigated [8].
 

Anatomical context of NTF3

 

Associations of NTF3 with chemical compounds

 

Other interactions of NTF3

  • In both structures, BDNF mRNA expression is maintained into adulthood, while NT-3 is undetectable in the adult [3].
 

Analytical, diagnostic and therapeutic context of NTF3

  • To assess potential roles for neurotrophins in these processes, we have examined the developmental expression of BDNF and NT-3 mRNA in the cat's visual system using in situ hybridization [3].
  • The axotomized medial gastrocnemius (MG) nerve was provided with NT-3 or NT-4/5 for 8-35 d via an osmotic minipump attached to its central end at the time of axotomy [8].
  • The microinjection of nerve growth factor and neurotrophin-3 into the rostro-dorsal pontine tegmentum of the cat evokes a state that is comparable to naturally-occurring rapid eye movement sleep [13].

References

  1. Effects of acupuncture on the expression of glial cell line-derived neurotrophic factor (GDNF) and basic fibroblast growth factor (FGF-2/bFGF) in the left sixth lumbar dorsal root ganglion following removal of adjacent dorsal root ganglia. Wang, T.T., Yuan, Y., Kang, Y., Yuan, W.L., Zhang, H.T., Wu, L.Y., Feng, Z.T. Neurosci. Lett. (2005) [Pubmed]
  2. A mathematical model of activity-dependent, anatomical segregation induced by competition for neurotrophic support. Elliott, T., Shadbolt, N.R. Biological cybernetics. (1996) [Pubmed]
  3. Dynamic regulation of BDNF and NT-3 expression during visual system development. Lein, E.S., Hohn, A., Shatz, C.J. J. Comp. Neurol. (2000) [Pubmed]
  4. Induction of rapid eye movement sleep by neurotrophin-3 and its co-localization with choline acetyltransferase in mesopontine neurons. Yamuy, J., Rojas, M.J., Torterolo, P., Sampogna, S., Chase, M.H. Neuroscience (2002) [Pubmed]
  5. L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Koelle, G.B., Sanville, U.J., Thampi, N.S., Wall, S.J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Partial characterization of the neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Koelle, G.B., Sanville, U.J., Rickard, K.K., Williams, J.E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  7. Demonstration of a neurotrophic factor for the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Koelle, G.B., Ruch, G.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  8. Neurotrophin modulation of the monosynaptic reflex after peripheral nerve transection. Mendell, L.M., Johnson, R.D., Munson, J.B. J. Neurosci. (1999) [Pubmed]
  9. Intravitreal injections of neurotrophic factors and forskolin enhance survival and axonal regeneration of axotomized beta ganglion cells in cat retina. Watanabe, M., Tokita, Y., Kato, M., Fukuda, Y. Neuroscience (2003) [Pubmed]
  10. Induction of rapid eye movement sleep by the microinjection of nerve growth factor into the pontine reticular formation of the cat. Yamuy, J., Morales, F.R., Chase, M.H. Neuroscience (1995) [Pubmed]
  11. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Koelle, G.B., Sanville, U.J., Wall, S.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  12. Effects of sodium pentobarbital anesthesia and neurotrophic factor on the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Koelle, G.B., Ruch, G.A., Uchida, E. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  13. The role of tropomyosin-related kinase receptors in neurotrophin-induced rapid eye movement sleep in the cat. Yamuy, J., Ramos, O., Torterolo, P., Sampogna, S., Chase, M.H. Neuroscience (2005) [Pubmed]
 
WikiGenes - Universities