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Gene Review

CPB1  -  carboxypeptidase B1 (tissue)

Bos taurus

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Disease relevance of LOC510039


High impact information on LOC510039


Biological context of LOC510039


Anatomical context of LOC510039

  • The amino-acid sequence of bovine carboxypeptidase B [peptidyl-L-lysine(-L-arginine)hydrolase, EC] has been determined using the heavy and light chains of the enzyme isolated from spontaneously activated pancreatic juice [9].
  • Peptides of up to 25,000 daltons that express opiate activity only following digestion with enzymes, such s trypsin and carboxypeptidase B, also are secreted from chromaffin cells in the same proportion of their cellular content as are catecholamines and opioid peptides [13].
  • Accordingly, C5a, purified from zymosan-activated human, and C5a des Arg, prepared by incubating C5a with immobilized porcine carboxypeptidase B, were studied for fibroblast chemotactic activity [14].
  • Purification of carboxypeptidase B from human pancreas [15].
  • A carboxypeptidase B-like enzyme was detected in the soluble fraction of purified insulin secretory granules, and implicated in insulin biosynthesis [16].

Associations of LOC510039 with chemical compounds


Other interactions of LOC510039


Analytical, diagnostic and therapeutic context of LOC510039


  1. Effect of surface roughness on hemolysis in a centrifugal blood pump. Takami, Y., Nakazawa, T., Makinouchi, K., Glueck, J., Benkowski, R., Nosé, Y. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1996) [Pubmed]
  2. Applications of the pulsatile flow versatile ECLS: in vivo studies. Rho, Y.R., Choi, H., Lee, J.C., Choi, S.W., Chung, Y.M., Lee, H.S., Hwang, C.M., Lee, H.S., Ahn, S.S., Lee, R.Y., Son, H.S., Choi, M.J., Baek, K.J., Kim, J.S., Suh, G.J., Won, Y.S., Sun, K., Min, B.G. The International journal of artificial organs. (2003) [Pubmed]
  3. Serum carboxypeptidase B levels during acute and mild Babesia divergens infections of adult cattle. Taylor, S.M., Elliott, C.T. Res. Vet. Sci. (1983) [Pubmed]
  4. Identification of human glandular kallikrein in the beta cell of the pancreas. ole-MoiYoi, O.K., Pinkus, G.S., Spragg, J., Austen, K.F. N. Engl. J. Med. (1979) [Pubmed]
  5. Cloning and sequence analysis of cDNA for bovine carboxypeptidase E. Fricker, L.D., Evans, C.J., Esch, F.S., Herbert, E. Nature (1986) [Pubmed]
  6. An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin. Lewis, R.V., Stern, A.S., Kimura, S., Rossier, J., Stein, S., Udenfriend, S. Science (1980) [Pubmed]
  7. Pancreatic carboxypeptidase hydrolysis of bile acid-amino conjugates: selective resistance of glycine and taurine amidates. Huijghebaert, S.M., Hofmann, A.F. Gastroenterology (1986) [Pubmed]
  8. Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor. Normant, E., Martres, M.P., Schwartz, J.C., Gros, C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Amino-acid sequence of bovine carboxypeptidase B. Titani, K., Ericsson, L.H., Walsh, K.A., Neurath, H. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  10. Structural characterization of the rat carboxypeptidase A1 and B genes. Comparative analysis of the rat carboxypeptidase gene family. Clauser, E., Gardell, S.J., Craik, C.S., MacDonald, R.J., Rutter, W.J. J. Biol. Chem. (1988) [Pubmed]
  11. Carboxyl-terminal proteolytic processing of matrix Gla protein. Hale, J.E., Williamson, M.K., Price, P.A. J. Biol. Chem. (1991) [Pubmed]
  12. By-product analogues for bovine carboxypeptidase B. McKay, T.J., Plummer, T.H. Biochemistry (1978) [Pubmed]
  13. Proportional secretion of opioid peptides and catecholamines from adrenal chromaffin cells in culture. Wilson, S.P., Chang, K.J., Viveros, O.H. J. Neurosci. (1982) [Pubmed]
  14. Human C5a and C5a des Arg exhibit chemotactic activity for fibroblasts. Senior, R.M., Griffin, G.L., Perez, H.D., Webster, R.O. J. Immunol. (1988) [Pubmed]
  15. Purification of carboxypeptidase B from human pancreas. Marinkovic, D.V., Marinkovic, J.N., Erdös, E.G., Robinson, C.J. Biochem. J. (1977) [Pubmed]
  16. The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Davidson, H.W., Hutton, J.C. Biochem. J. (1987) [Pubmed]
  17. Pituitary enzyme conversion of putative synthetic oxytocin precursor intermediates. Kanmera, T., Chaiken, I.M. J. Biol. Chem. (1985) [Pubmed]
  18. PA28, an activator of the 20 S proteasome, is inactivated by proteolytic modification at its carboxyl terminus. Ma, C.P., Willy, P.J., Slaughter, C.A., DeMartino, G.N. J. Biol. Chem. (1993) [Pubmed]
  19. Processing of proenkephalin in adrenal chromaffin cells. Wilson, S.P. J. Neurochem. (1991) [Pubmed]
  20. Identification of a proenkephalin precursor in striatal tissue. Beaumont, A., Metters, K.M., Rossier, J., Hughes, J. J. Neurochem. (1985) [Pubmed]
  21. Vitamin K and the biosynthesis of prothrombin. V. Gamma-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin. Fernlund, P., Stenflo, J., Roepstorff, P., Thomsen, J. J. Biol. Chem. (1975) [Pubmed]
  22. Serum acetylcholinesterase possesses trypsin-like and carboxypeptidase B-like activity. Small, D.H. Neurosci. Lett. (1988) [Pubmed]
  23. Cell-free translation and partial characterization of mRNA coding for enkephalin-precursor protein. Dandekar, S., Sabol, S.L. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  24. In vitro biosynthesis and processing of immunologically identified methionine-enkephalin precursor protein. Sabol, S.L., Liang, C.M., Dandekar, S., Kranzler, L.S. J. Biol. Chem. (1983) [Pubmed]
  25. Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma. Eaton, D.L., Malloy, B.E., Tsai, S.P., Henzel, W., Drayna, D. J. Biol. Chem. (1991) [Pubmed]
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