Disease relevance of SIAE

• Escherichia coli was isolated from 26% (26/100) of the samples from the LSE group and from 6% (2/32) of those from the HSE group (P = 0.03) [1].

Psychiatry related information on SIAE

• Scalp-recorded sensory evoked potentials (EPs) elicited by left and right median nerve stimulation (LSEP and RSEP), checkerboard pattern flash (VEP) and acoustic click (AEP) were obtained in 22 individuals 'at risk' (AR) for Huntington's disease and 22 hospitalized neurotic patients matched for age, gender and intelligence [2].

High impact information on SIAE

• We previously reported a cDNA encoding a lysosomal sialic acid-specific 9-O-acetylesterase, which traverses the endoplasmic reticulum-Golgi pathway and localizes primarily to lysosomes and endosomes [3].
• EPs to left median nerve (LSEP), right median nerve (RSEP), visual (VEP), and auditory (AEP) stimul were recorded from 15 leads [4].
• Adequacy of lactation was assessed in Teheran women of low (LSE) and lower-middle (MSE) socioeconomic status in the third month postpartum, as part of a study linking nutrition, hormonal status, and lactation [5].
• K-means clustering of genes revealed four major patterns of gene expression (high in PE, high in ESE, high in MSE, and high in LSE), and gene ontology analysis of these clusters demonstrated cycle-phase-specific biological processes and molecular functions [6].
• Unsupervised principal component analysis of all samples revealed that samples self-cluster into four groups consistent with histological phenotypes of proliferative (PE), early-secretory (ESE), mid-secretory (MSE), and late-secretory (LSE) endometrium [6].

Biological context of SIAE

• This study demonstrates the ability of the epidural LSEP to provide more information than the surface LSEP of the functional condition of the lumbosacral spinal cord, particularly regarding the character of the propagating action potentials and in cases when the surface LSEPs appear to be of very low amplitude or absent [7].
• Variability of the lumbosacral somatosensory evoked potential (LSEP) in test/retest situations was assessed in 49 patients with nonprogressive neurological disorder and 20 healthy subjects [8].
• In contrast, IC50, 1.32%, for the MTT assay in LSE-high was much lower than that using guinea pig skin [9].
• RESULTS: The time course of cell viability in the skin after application of CPC to intact skin was distinctly different from that of stratum-corneum-stripped skin in both LSE-high and hairless mice [10].
• Study objective: The American Board of Emergency Medicine (ABEM) Longitudinal Study of Emergency Physicians (LSEP) was initiated to describe the development of a new medical specialty through the continuing study of the lives of representative emergency physicians [11].

Anatomical context of SIAE

• In patients with cauda equina lesion, each major component of LSEP can be absent or the peak can have a reduced amplitude and a prolonged latency [12].
• Exposure of LSE to SLS induced a marked increase of IL-6 production in fibroblasts incorporated in the collagen matrix [13].
• Two human skin recombinants, the epidermis reconstructed on the deepidermized dermis (RE-DED) or on fibroblast-populated collagen matrix (Living Skin Equivalent, LSE), were used to study the irritating effect of sodium lauryl sulfate (SLS) [13].
• Assuming that the LSEP reflects the activity of spinal cord interneurons, the results demonstrate a degree of spinal cord dysfunction caudal to the area of injury in a substantial number of the patients with spinal cord injury which we studied [14].
• RESULTS: The girls from LSE not only had lower attained weight, height, skinfold thickness at triceps and body fat but also had a significant difference (p < 0.05) in menarcheal age (15.4 yr) as compared to girls from HSE (12.1 yr) [15].

Associations of SIAE with chemical compounds

• The LSE method shows great practical advantages, such as ease of preparation, saving of time, and smaller sample volumes, but needs to be investigated further with respect to robustness and the removal of an endogenous compound that interfered with the quantitation of oxmetidine at low concentrations [16].
• The fraction of dead cell number in the MTT assay or the Draize irritation score (in vitro and in vivo irritation data, respectively) was treated as a function of CPC concentration in the viable skin of LSE-high and guinea pig [9].
• Radiant heat stimulation was applied with a CO2 laser and somatosensory evoked vertex potentials (LSEP) were recorded while the subjects were simultaneously engaged in an adaptive pursuit tracking task in order to stabilize their vigilance [17].
• In the present study, a three-dimensional cultured human skin model (living skin equivalent-high, LSE-high) was used as a cultured skin membrane and tetracycline HCl (TC-HCl) and chloramphenicol (CP) were used as antibiotics [18].
• A solid-liquid extraction (LSE) procedure with Extrelut cartridge (diatomaceous earth) using different eluents was developed to obtain polyphenolic compounds [19].

Analytical, diagnostic and therapeutic context of SIAE

• A preliminary liquid-solid sample preparation scheme (LSE) for the HPLC determination of oxmetidine in human plasma is compared with the existing liquid-liquid extraction [16].

References