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Gene Review

SIAE  -  sialic acid acetylesterase

Homo sapiens

Synonyms: AIS6, CSE-C, CSEC, H-Lse, LSE, ...
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Disease relevance of SIAE

  • Escherichia coli was isolated from 26% (26/100) of the samples from the LSE group and from 6% (2/32) of those from the HSE group (P = 0.03) [1].

Psychiatry related information on SIAE

  • Scalp-recorded sensory evoked potentials (EPs) elicited by left and right median nerve stimulation (LSEP and RSEP), checkerboard pattern flash (VEP) and acoustic click (AEP) were obtained in 22 individuals 'at risk' (AR) for Huntington's disease and 22 hospitalized neurotic patients matched for age, gender and intelligence [2].

High impact information on SIAE

  • We previously reported a cDNA encoding a lysosomal sialic acid-specific 9-O-acetylesterase, which traverses the endoplasmic reticulum-Golgi pathway and localizes primarily to lysosomes and endosomes [3].
  • EPs to left median nerve (LSEP), right median nerve (RSEP), visual (VEP), and auditory (AEP) stimul were recorded from 15 leads [4].
  • Adequacy of lactation was assessed in Teheran women of low (LSE) and lower-middle (MSE) socioeconomic status in the third month postpartum, as part of a study linking nutrition, hormonal status, and lactation [5].
  • K-means clustering of genes revealed four major patterns of gene expression (high in PE, high in ESE, high in MSE, and high in LSE), and gene ontology analysis of these clusters demonstrated cycle-phase-specific biological processes and molecular functions [6].
  • Unsupervised principal component analysis of all samples revealed that samples self-cluster into four groups consistent with histological phenotypes of proliferative (PE), early-secretory (ESE), mid-secretory (MSE), and late-secretory (LSE) endometrium [6].

Biological context of SIAE

  • This study demonstrates the ability of the epidural LSEP to provide more information than the surface LSEP of the functional condition of the lumbosacral spinal cord, particularly regarding the character of the propagating action potentials and in cases when the surface LSEPs appear to be of very low amplitude or absent [7].
  • Variability of the lumbosacral somatosensory evoked potential (LSEP) in test/retest situations was assessed in 49 patients with nonprogressive neurological disorder and 20 healthy subjects [8].
  • In contrast, IC50, 1.32%, for the MTT assay in LSE-high was much lower than that using guinea pig skin [9].
  • RESULTS: The time course of cell viability in the skin after application of CPC to intact skin was distinctly different from that of stratum-corneum-stripped skin in both LSE-high and hairless mice [10].
  • Study objective: The American Board of Emergency Medicine (ABEM) Longitudinal Study of Emergency Physicians (LSEP) was initiated to describe the development of a new medical specialty through the continuing study of the lives of representative emergency physicians [11].

Anatomical context of SIAE

  • In patients with cauda equina lesion, each major component of LSEP can be absent or the peak can have a reduced amplitude and a prolonged latency [12].
  • Exposure of LSE to SLS induced a marked increase of IL-6 production in fibroblasts incorporated in the collagen matrix [13].
  • Two human skin recombinants, the epidermis reconstructed on the deepidermized dermis (RE-DED) or on fibroblast-populated collagen matrix (Living Skin Equivalent, LSE), were used to study the irritating effect of sodium lauryl sulfate (SLS) [13].
  • Assuming that the LSEP reflects the activity of spinal cord interneurons, the results demonstrate a degree of spinal cord dysfunction caudal to the area of injury in a substantial number of the patients with spinal cord injury which we studied [14].
  • RESULTS: The girls from LSE not only had lower attained weight, height, skinfold thickness at triceps and body fat but also had a significant difference (p < 0.05) in menarcheal age (15.4 yr) as compared to girls from HSE (12.1 yr) [15].

Associations of SIAE with chemical compounds

  • The LSE method shows great practical advantages, such as ease of preparation, saving of time, and smaller sample volumes, but needs to be investigated further with respect to robustness and the removal of an endogenous compound that interfered with the quantitation of oxmetidine at low concentrations [16].
  • The fraction of dead cell number in the MTT assay or the Draize irritation score (in vitro and in vivo irritation data, respectively) was treated as a function of CPC concentration in the viable skin of LSE-high and guinea pig [9].
  • Radiant heat stimulation was applied with a CO2 laser and somatosensory evoked vertex potentials (LSEP) were recorded while the subjects were simultaneously engaged in an adaptive pursuit tracking task in order to stabilize their vigilance [17].
  • In the present study, a three-dimensional cultured human skin model (living skin equivalent-high, LSE-high) was used as a cultured skin membrane and tetracycline HCl (TC-HCl) and chloramphenicol (CP) were used as antibiotics [18].
  • A solid-liquid extraction (LSE) procedure with Extrelut cartridge (diatomaceous earth) using different eluents was developed to obtain polyphenolic compounds [19].

Analytical, diagnostic and therapeutic context of SIAE

  • A preliminary liquid-solid sample preparation scheme (LSE) for the HPLC determination of oxmetidine in human plasma is compared with the existing liquid-liquid extraction [16].


  1. Bacterial contamination of the lacteal contents of feeding bottles in metropolitan São Paulo, Brazil. Morais, T.B., Morais, M.B., Sigulem, D.M. Bull. World Health Organ. (1998) [Pubmed]
  2. A sensory evoked potential comparison of persons 'at risk' for Huntington's disease and hospitalized neurotic patients. Josiassen, R.C., Shagass, C., Roemer, R.A., Mancall, E. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. (1988) [Pubmed]
  3. Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can Be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus. Takematsu, H., Diaz, S., Stoddart, A., Zhang, Y., Varki, A. J. Biol. Chem. (1999) [Pubmed]
  4. Intelligence as a factor in evoked potential studies of psychopathology. I. Comparison of low and high IQ subjects. Shagass, C., Roemer, R.A., Straumanis, J.J., Josiassen, R.C. Biol. Psychiatry (1981) [Pubmed]
  5. Lactation and pregnancy in Iran. I. Social and economic aspects. Geissler, C., Calloway, D.H., Margen, S. Am. J. Clin. Nutr. (1978) [Pubmed]
  6. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Talbi, S., Hamilton, A.E., Vo, K.C., Tulac, S., Overgaard, M.T., Dosiou, C., Le Shay, N., Nezhat, C.N., Kempson, R., Lessey, B.A., Nayak, N.R., Giudice, L.C. Endocrinology (2006) [Pubmed]
  7. Surface and epidural lumbosacral spinal cord evoked potentials in chronic spinal cord injury. Stĕtkárová, I., Halter, J.A., Dimitrijevic, M.R. J. Neurotrauma (1993) [Pubmed]
  8. Stability of lumbosacral somatosensory evoked potentials in a long-term follow-up. Berić, A. Muscle Nerve (1988) [Pubmed]
  9. Utility of MTT assay in three-dimensional cultured human skin model as an alternative for draize skin irritation test: approach using diffusion law of irritant in skin and toxicokinetics-toxicodynamics correlation. Watanabe, T., Hasegawa, T., Takahashi, H., Ishibashi, T., Itagaki, H., Sugibayashi, K. Pharm. Res. (2002) [Pubmed]
  10. Kinetic analysis on the skin disposition of cytotoxicity as an index of skin irritation produced by cetylpyridinium chloride: comparison of in vitro data using a three-dimensional cultured human skin model with in vivo results in hairless mice. Kano, S., Sugibayashi, K. Pharm. Res. (2006) [Pubmed]
  11. American Board of Emergency Medicine Longitudinal Study of Emergency Physicians. Reinhart, M.A., Munger, B.S., Rund, D.A. Annals of emergency medicine. (1999) [Pubmed]
  12. Lumbosacral evoked potentials (LSEPs) and cortical somatosensory evoked potentials (SEPs) in patients with lesions of the conus medullaris and cauda equina. Lehmkuhl, L.D., Dimitrijevic, M.R., Zidar, J. Electroencephalography and clinical neurophysiology. (1988) [Pubmed]
  13. Use of human skin recombinants as an in vitro model for testing the irritation potential of cutaneous irritants. Ponec, M., Kempenaar, J. Skin Pharmacol. (1995) [Pubmed]
  14. Electrophysiological characteristics of lumbosacral evoked potentials in patients with established spinal cord injury. Lehmkuhl, D., Dimitrijevic, M.R., Renouf, F. Electroencephalography and clinical neurophysiology. (1984) [Pubmed]
  15. Height velocity, body fat and menarcheal age of Indian girls. Rao, S., Joshi, S., Kanade, A. Indian pediatrics. (1998) [Pubmed]
  16. High-performance liquid chromatographic determination of oxmetidine in human plasma: comparison of liquid-liquid and liquid-solid extraction techniques. McDowall, R.D., Murkitt, G.S., Walford, J.A. J. Chromatogr. (1984) [Pubmed]
  17. Analgesic effect of acetylsalicylic acid (ASA) versus a lithium-ASA combination: an evoked potential study employing radiant heat stimulation with a CO2 laser. Schaffler, K., Reeh, P.W., Zentzis, K., Hamperl, W. Pharmacopsychiatry (1987) [Pubmed]
  18. Cultured skin loaded with tetracycline HCl and chloramphenicol as dermal delivery system: mathematical evaluation of the cultured skin containing antibiotics. Hada, N., Hasegawa, T., Takahashi, H., Ishibashi, T., Sugibayashi, K. Journal of controlled release : official journal of the Controlled Release Society. (2005) [Pubmed]
  19. Polyphenolic content in five tuscany cultivars of Olea europaea L. Romani, A., Mulinacci, N., Pinelli, P., Vincieri, F.F., Cimato, A. J. Agric. Food Chem. (1999) [Pubmed]
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