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Gene Review

Dpt  -  dermatopontin

Mus musculus

Synonyms: 1810032B19Rik, 5033416F05Rik, Dermatopontin, EQ-1, Early quiescence protein 1, ...
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Disease relevance of Dpt


High impact information on Dpt

  • The full-length EQ-1 cDNA, cloned from a mouse lung cDNA library, is 1673 bp in length and consists of 26 bp 5' untranslated region, 603 bp coding region, and 1044 bp 3' untranslated region, the latter of which harbors two polyadenylation signals [3].
  • The stably transfected cell line harboring EQ-1 driven by an inducible promoter showed approximately 50% inhibition on cell proliferation after being treated with an inducer for 5 days [3].
  • This study was conducted to determine whether DPT has a direct role in corneal matrix organization by investigating the ultrastructure of Dpt-null (Dpt(-/-)) mouse corneas [4].
  • RESULTS: Light microscopy demonstrated that Dpt(-/-) corneas in 2-month-old mice showed a 24% reduction in average stromal thickness compared with wild type (P < 0.001) [4].
  • PURPOSE: Dermatopontin (DPT) is an abundant component of the stromal extracellular matrix; however, its function in the cornea is poorly understood [4].

Biological context of Dpt


Anatomical context of Dpt

  • Remarkably, light microscopy study showed a significant decrease in the relative thickness of the dermis in dermatopontin-null mice compared with wild-type mice (45.2 +/- 3.09% and 57.8 +/- 4.25%, respectively) [7].
  • Using a chick model, strains EQ1, BLR and BL21 invaded livers but not spleens; only strain EQ1 persisted in the chick gut [2].
  • Spatio-temporal expression and regulation of dermatopontin in the early pregnant mouse uterus [6].

Associations of Dpt with chemical compounds


Regulatory relationships of Dpt


Analytical, diagnostic and therapeutic context of Dpt

  • Examination of Dpt(-/-) stroma by transmission electron microscopy indicated significant disruption of fibril spacing within the posterior lamellae, whereas the mid and anterior regions appeared largely unaffected compared with wild type [4].
  • Computer-assisted peptide fingerprint analysis of the MS profiles was used to identify C-terminal lysine-6-oxidase; dermatopontin (DPT); histones H2A2, H2A3, and H2B; and trace amounts of gamma-actin [8].


  1. Extracellular matrix dermatopontin modulates prostate cell growth in vivo. Takeuchi, T., Suzuki, M., Kumagai, J., Kamijo, T., Sakai, M., Kitamura, T. J. Endocrinol. (2006) [Pubmed]
  2. An investigation into the pathogenic properties of Escherichia coli strains BLR, BL21, DH5alpha and EQ1. Chart, H., Smith, H.R., La Ragione, R.M., Woodward, M.J. J. Appl. Microbiol. (2000) [Pubmed]
  3. Cloning of murine early quiescence-1 gene: the murine counterpart of dermatopontin gene can induce and be induced by cell quiescence. Tzen, C.Y., Huang, Y.W. Exp. Cell Res. (2004) [Pubmed]
  4. The role of dermatopontin in the stromal organization of the cornea. Cooper, L.J., Bentley, A.J., Nieduszynski, I.A., Talabani, S., Thomson, A., Utani, A., Shinkai, H., Fullwood, N.J., Brown, G.M. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  5. Physicochemical and immunochemical characterization of the high molecular weight allergens from dermatophagoides pteronysisinus with particular reference to the tridacnin, Con-A and S107 reactive components. Stewart, G.A., Turner, K.J. The Australian journal of experimental biology and medical science. (1980) [Pubmed]
  6. Spatio-temporal expression and regulation of dermatopontin in the early pregnant mouse uterus. Kim, H.S., Cheon, Y.P. Mol. Cells (2006) [Pubmed]
  7. Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis. Takeda, U., Utani, A., Wu, J., Adachi, E., Koseki, H., Taniguchi, M., Matsumoto, T., Ohashi, T., Sato, M., Shinkai, H. J. Invest. Dermatol. (2002) [Pubmed]
  8. BMP Stimulation of Alkaline Phosphatase Activity in Pluripotent Mouse C2C12 Cells is Inhibited by Dermatopontin, One of the Most Abundant Low Molecular Weight Proteins in Demineralized Bone Matrix. Behnam, K., Murray, S.S., Brochmann, E.J. Connect. Tissue Res. (2006) [Pubmed]
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