Disease relevance of DPT

• Fibroblast cultures from systemic sclerosis patient involved skin also showed significantly reduced expression of dermatopontin compared with normal skin fibroblasts from healthy individuals [1].
• In this study we examined the expression of dermatopontin mRNA and protein in skin fibroblast cultures from patients with hypertrophic scar and patients with systemic sclerosis [1].
• Our results suggest that the decreased expression of dermatopontin is associated with the pathogenesis of fibrosis in hypertrophic scar and systemic sclerosis, and that the effect of the cytokines and matrix collagen on dermatopontin may have important implications for skin fibrosis [1].
• IgM antitetanus antibodies were in their blood before immunization with diphtheria, pertussis, tetanus vaccine (DPT), they had a more rapid (P less than 0.01) response to DPT immunization, and they were still highly sensitized (P less than 0.01) to tetanus 13 mo after birth [2].
• A randomized, double-blind, placebo-controlled trial was conducted to evaluate the effect of simultaneous vitamin A supplementation and diphtheria, pertussis and tetanus (DPT) vaccination on the antibody levels [3].

Psychiatry related information on DPT

• Although PO ketamine/midazolam provided superior sedation and amnesia compared to IM DPT, this regimen may require the supervision of an anesthesiologist for safe use [4].

High impact information on DPT

• Molecular evolution and functionally important structures of molluscan Dermatopontin: implications for the origins of molluscan shell matrix proteins [5].
• Reduction in dermatopontin was associated with an increase in transforming growth factor-beta3 (TGFB3) mRNA levels in leiomyomas, whereas other genes involved in dermatopontin signaling were not differentially expressed [6].
• Immunohistochemical studies of leiomyomas and keloids demonstrated reduced levels of dermatopontin in both tissues [6].
• In particular, decreased expression of dermatopontin represents a molecular link between the leiomyoma and keloid phenotypes [6].
• Both La3+ and DPT inhibited cell proliferation and SOC entry [7].

Chemical compound and disease context of DPT

• One hundred twenty infants were randomly assigned to receive either 15 mg vitamin A or placebo with each of three DPT/OPV (diphtheria, pertussis, tetanus/oral polio vaccine) immunizations at monthly intervals [8].
• However, in four cases of steroid-responsive, DAT-negative hemolytic anemia, the DPT supported the diagnosis of AIHA when the eluate did not react [9].
• The use of the direct manual hexadimethrine bromide (Polybrene) test (DPT) in the investigation of patients for autoimmune hemolytic anemia (AIHA) was evaluated [9].
• STUDY SELECTION AND DATA EXTRACTION: We selected epidemiological studies with original data on the correlation between vaccination with diphtheria, pertussis, tetanus (DPT), measles, mumps, rubella (MMR) and Bacillus Calmette-Guérin (BCG) vaccine in infancy and the development of allergic diseases, and assessed their quality and validity [10].
• Generalized eczema in an 18-month-old boy due to phenoxyethanol in DPT vaccine [11].

Biological context of DPT

• The three clones that were characterized contain an open reading frame (603 bp) coding for 201 amino acids comprising a secretory leader peptide of 18 amino acids and a secreted part of 183 amino acids with 96% identity to the bovine sequence, indicating that they code for the human homologue ("dermatopontin") of the bovine 22K protein [12].
• Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin) [12].
• Analogous to MEF, the anti-proliferative effect of DPT was mediated by cell cycle arrest and not by induction of apoptosis [7].
• These results suggest that antibody response to diphtheria vaccination was potentiated by simultaneous vitamin A administration and DPT immunization [3].
• It is suggested that the convergence of an insulotropic variant virus, genetic predisposition, and perhaps some uncontrolled adjuvant factors, e.g. steroid therapy and DPT vaccination, may have determined insular damage and anti-islet autoimmune reactions, leading to insulin-dependent diabetes mellitus [13].

Anatomical context of DPT

• We also investigated the effects of cytokines and matrix collagen on dermatopontin expression in normal cultured fibroblasts [1].
• Expression of dermatopontin is not limited to connective tissue, as Northern blots show specific mRNAs in cultured fibroblasts, muscle, heart, pancreas, and lung [12].
• We found that the T cell clones CFTS4:2.80 and CFTS4:2.6 with the required restriction element responded to the house dust mite antigen DPT presented by I937 but not U937, whereas CFTS4:3.1, which is not HLA-DR restricted, did not respond to either cell line [14].
• A new combined DPT-Poliovirus vaccine (DPTP) has been developed in France. It contains the DPT components mixed with poliovirus antigens, prepared by culture on vero cells on microcarriers, inactivated by formalin and formulated at a level of 40-8-32 D-antigen units for the type 1, 2 and 3 respectively [15].
• Dermatopontin is widespread in mammalian extracellular matrices, including the matrix of biominerals such as bone and teeth [16].

Associations of DPT with chemical compounds

• Infants aged 6-17 wk (n = 56) were randomly given 15 mg oral vitamin A or placebo at the time of their DPT immunization [3].
• Reappraisal of lytic cocktail/demerol, phenergan, and thorazine (DPT) for the sedation of children [17].
• Supplemental propofol was more frequently required (P < or = 0.02) and in larger doses (P < 0.05) after IM DPT [4].
• Each patient simultaneously wore one 5-mg Transderm-Nitro (TDN) patch and one 5-mg Deponit (DPT) patch [18].
• The vitrification solutions consisted of 2.75 M DMSO and 2.75 M PG in M2 medium supplemented with 1 M trehalose (DPT), 1 M sucrose (DPS), or 1 M raffinose (DPR) [19].

Other interactions of DPT

• Dermatopontin is a recently discovered extracellular matrix protein with proteoglycan and cell-binding properties and is assumed to play important roles in cell-matrix interactions and matrix assembly [1].
• Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen [1].
• CONCLUSIONS: Large local reactions occur frequently after the preschool administration of the DPT vaccine [20].
• Market share liability for pharmaceuticals. The distinction between DES and DPT [21].

Analytical, diagnostic and therapeutic context of DPT

• Raised serum IgE associated with reduced responsiveness to DPT vaccination during infancy [22].
• A direct antiglobulin test (DAT) using monospecific reagents and the DPT were performed, and a concentrated ether eluate was tested [9].
• Undernourished men (n = 5; body mass index 16.3 +/- 0.9 kg/m(2)) and children (n = 9; age 4.1 +/- 0.6 y; weight-for-age Z-score -2.3 +/- 0.7) underwent metabolic studies 6 d before and 1 d after vaccination with diphtheria, pertussis and tetanus (DPT) [23].
• Serological evaluation of a simplified immunization schedule using quadruple DPT-polio vaccine in Burkina Faso [24].
• At 1 year of age, 29 of 122 (24%) of the control group had received all three DPT/OPV immunizations, compared with 33 (28%) of 116 infants in the intervention group [25].

References