The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DPT  -  dermatopontin

Homo sapiens

Synonyms: Dermatopontin, TRAMP, Tyrosine-rich acidic matrix protein
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DPT


Psychiatry related information on DPT

  • Although PO ketamine/midazolam provided superior sedation and amnesia compared to IM DPT, this regimen may require the supervision of an anesthesiologist for safe use [4].

High impact information on DPT


Chemical compound and disease context of DPT


Biological context of DPT


Anatomical context of DPT

  • We also investigated the effects of cytokines and matrix collagen on dermatopontin expression in normal cultured fibroblasts [1].
  • Expression of dermatopontin is not limited to connective tissue, as Northern blots show specific mRNAs in cultured fibroblasts, muscle, heart, pancreas, and lung [12].
  • We found that the T cell clones CFTS4:2.80 and CFTS4:2.6 with the required restriction element responded to the house dust mite antigen DPT presented by I937 but not U937, whereas CFTS4:3.1, which is not HLA-DR restricted, did not respond to either cell line [14].
  • A new combined DPT-Poliovirus vaccine (DPTP) has been developed in France. It contains the DPT components mixed with poliovirus antigens, prepared by culture on vero cells on microcarriers, inactivated by formalin and formulated at a level of 40-8-32 D-antigen units for the type 1, 2 and 3 respectively [15].
  • Dermatopontin is widespread in mammalian extracellular matrices, including the matrix of biominerals such as bone and teeth [16].

Associations of DPT with chemical compounds

  • Infants aged 6-17 wk (n = 56) were randomly given 15 mg oral vitamin A or placebo at the time of their DPT immunization [3].
  • Reappraisal of lytic cocktail/demerol, phenergan, and thorazine (DPT) for the sedation of children [17].
  • Supplemental propofol was more frequently required (P < or = 0.02) and in larger doses (P < 0.05) after IM DPT [4].
  • Each patient simultaneously wore one 5-mg Transderm-Nitro (TDN) patch and one 5-mg Deponit (DPT) patch [18].
  • The vitrification solutions consisted of 2.75 M DMSO and 2.75 M PG in M2 medium supplemented with 1 M trehalose (DPT), 1 M sucrose (DPS), or 1 M raffinose (DPR) [19].

Other interactions of DPT


Analytical, diagnostic and therapeutic context of DPT


  1. Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. Kuroda, K., Okamoto, O., Shinkai, H. J. Invest. Dermatol. (1999) [Pubmed]
  2. Transplacental immunization of the human fetus to tetanus by immunization of the mother. Gill, T.J., Repetti, C.F., Metlay, L.A., Rabin, B.S., Taylor, F.H., Thompson, D.S., Cortese, A.L. J. Clin. Invest. (1983) [Pubmed]
  3. Simultaneous vitamin A administration at routine immunization contact enhances antibody response to diphtheria vaccine in infants younger than six months. Rahman, M.M., Mahalanabis, D., Hossain, S., Wahed, M.A., Alvarez, J.O., Siber, G.R., Thompson, C., Santosham, M., Fuchs, G.J. J. Nutr. (1999) [Pubmed]
  4. Oral ketamine/midazolam is superior to intramuscular meperidine, promethazine, and chlorpromazine for pediatric cardiac catheterization. Auden, S.M., Sobczyk, W.L., Solinger, R.E., Goldsmith, L.J. Anesth. Analg. (2000) [Pubmed]
  5. Molecular evolution and functionally important structures of molluscan Dermatopontin: implications for the origins of molluscan shell matrix proteins. Sarashina, I., Yamaguchi, H., Haga, T., Iijima, M., Chiba, S., Endo, K. J. Mol. Evol. (2006) [Pubmed]
  6. Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids. Catherino, W.H., Leppert, P.C., Stenmark, M.H., Payson, M., Potlog-Nahari, C., Nieman, L.K., Segars, J.H. Genes Chromosomes Cancer (2004) [Pubmed]
  7. Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells. Weiss, H., Amberger, A., Widschwendter, M., Margreiter, R., Ofner, D., Dietl, P. Int. J. Cancer (2001) [Pubmed]
  8. Effect of early vitamin A supplementation on cell-mediated immunity in infants younger than 6 mo. Rahman, M.M., Mahalanabis, D., Alvarez, J.O., Wahed, M.A., Islam, M.A., Habte, D. Am. J. Clin. Nutr. (1997) [Pubmed]
  9. Evaluation of the manual hexadimethrine bromide (Polybrene) technique in the investigation of autoimmune hemolytic anemia. Owen, I., Hows, J. Transfusion (1990) [Pubmed]
  10. No epidemiological evidence for infant vaccinations to cause allergic disease. Koppen, S., de Groot, R., Neijens, H.J., Nagelkerke, N., van Eden, W., Rümke, H.C. Vaccine (2004) [Pubmed]
  11. Generalized eczema in an 18-month-old boy due to phenoxyethanol in DPT vaccine. Vogt, T., Landthaler, M., Stolz, W. Contact Derm. (1998) [Pubmed]
  12. Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin). Superti-Furga, A., Rocchi, M., Schäfer, B.W., Gitzelmann, R. Genomics (1993) [Pubmed]
  13. Virologic, immunologic, and genetic factors in insulin-dependent diabetes mellitus. Champsaur, H.F., Bottazzo, G.F., Bertrams, J., Assan, R., Bach, C. J. Pediatr. (1982) [Pubmed]
  14. The 'monocytic' cell line I937 displays typical B cell characteristics. Reischl, I.G., Pöllabauer, E.M., Peiritsch, S., Schlager, S., Gladstone, P., Vooijs, W.C., Woisetschläger, M., Mudde, G.C. Immunol. Lett. (1996) [Pubmed]
  15. Evaluation of a new combined inactivated DPT-polio vaccine. Drucker, J., Soula, G., Diallo, O., Fabre, P. Dev. Biol. Stand. (1986) [Pubmed]
  16. The major soluble 19.6 kDa protein of the organic shell matrix of the freshwater snail Biomphalaria glabrata is an N-glycosylated dermatopontin. Marxen, J.C., Nimtz, M., Becker, W., Mann, K. Biochim. Biophys. Acta (2003) [Pubmed]
  17. Reappraisal of lytic cocktail/demerol, phenergan, and thorazine (DPT) for the sedation of children. Parks, B.R., Snodgrass, S.R. Pediatrics (1996) [Pubmed]
  18. A multicenter comparison of adhesion, preference, tolerability, and safety characteristics of two transdermal nitroglycerin delivery systems: Transderm-Nitro and Deponit. Chinoy, D.A., Camp, J., Elchahal, S., Godoy, C., Grossman, W., Hai, H., Hamilton, W., Kushner, M., McGreevy, M., Mulvihill, R.J. Clinical therapeutics. (1989) [Pubmed]
  19. Vitrification of pronuclear-stage mouse embryos on solid surface (SSV) versus in cryotube: comparison of the effect of equilibration time and different sugars in the vitrification solution. Bagis, H., Sagirkaya, H., Mercan, H.O., Dinnyès, A. Mol. Reprod. Dev. (2004) [Pubmed]
  20. Adverse reactions to the preschool (fifth) dose of adsorbed diphtheria-pertussis-tetanus vaccine in Canadian children. Scheifele, D.W., Meekison, W., Grace, M., Barreto, L., Carter, A.O., Mitchell, L., Farley, J. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1991) [Pubmed]
  21. Market share liability for pharmaceuticals. The distinction between DES and DPT. Fern, F.H., McHugh, L.S. The Journal of legal medicine. (1990) [Pubmed]
  22. Raised serum IgE associated with reduced responsiveness to DPT vaccination during infancy. Prescott, S.L., Sly, P.D., Holt, P.G. Lancet (1998) [Pubmed]
  23. A minimally invasive tracer protocol is effective for assessing the response of leucine kinetics and oxidation to vaccination in chronically energy-deficient adult males and children. Kurpad, A.V., Jahoor, F., Borgonha, S., Poulo, S., Rekha, S., Fjeld, C.R., Reeds, P.J. J. Nutr. (1999) [Pubmed]
  24. Serological evaluation of a simplified immunization schedule using quadruple DPT-polio vaccine in Burkina Faso. Rümke, H.C., Schlumberger, M., Floury, B., Nagel, J., van Steenis, B. Vaccine (1993) [Pubmed]
  25. The effect of patient education on pediatric immunization rates. Oeffinger, K.C., Roaten, S.P., Hitchcock, M.A., Oeffinger, P.K. The Journal of family practice. (1992) [Pubmed]
WikiGenes - Universities