Disease relevance of Tnfsf14

• Experimental influenza A virus myocarditis in mice. Light and electron microscopic, virologic, and hemodynamic study [1].
• Herpes simplex virus types 1 and 2 in organotypic cultures of mouse central and peripheral nervous system. I. Light microscopic observations of myelin degeneration [2].
• Cryoelectron microscopy and three-dimensional computer reconstruction techniques have been used to compare the structures of two types of DNA-free capsids of equine herpesvirus 1 at a resolution of 4.5 nm. "Light" capsids are abortive, whereas "intermediate" capsids are related to maturable intracellular precursors [3].
• PURPOSE: Light-elicited retinal ganglion cell (RGC) responses after fetal neural retinal transplantation have not been demonstrated in animal or human subjects blind from outer retinal degeneration, despite apparent morphologic success [4].
• RESULTS: Light microscopy revealed either normal renal architecture or glomerulosclerosis, tubular dedifferentiation and atrophy, and mild interstitial fibrosis [5].

High impact information on Tnfsf14

• We have sequenced the tyrosinase-related protein-1 cDNA encoded at this locus from Light mice and found that it contains a single base alteration from wild-type, causing an Arg to Cys change in the protein [6].
• To further elucidate the mutant phenotype, we studied the expression of melanocyte specific genes in the skin of Light mice [6].
• The tumor-necrosis factor superfamily member LIGHT (also known as TNFSF-14) is a ligand of stromal cell-expressed lymphotoxin-beta receptor and T cell-expressed herpes viral entry mediator (HVEM) [7].
• In this study, we followed cutaneous mast cells in chronic GVHD over 9 mo by three methods: Light microscopy of toluidine blue-stained sections showed that mast cells not seen at day 42 reappeared between days 94 and 125, were supramaximal at days 146 and 164, and returned to normal levels at days 195 and 280 [8].
• Analysis of B cell receptor production and rearrangement. Part I. Light chain rearrangement [9].

Chemical compound and disease context of Tnfsf14

• Circadian variations of organ specific and lethal toxicities were investigated in female C3H mice following intraperitoneal injection(s) of 5-fluorouracil (5-FU) and/or cis-platinum (CDDP) with different doses at one of the four equidistant time points, viz., 3, 9, 15 and 21 HALO (Hours After Light On) [10].
• Experimental coxsackie B-3 virus myocarditis in golden hamsters. Light and electron microscopy findings in a long-term follow-up study [11].

Biological context of Tnfsf14

• Effects of cytochalasin B on cytokinesis in mouse blastomeres. I. Light microscopic study [12].
• PURPOSE: Light-driven translocation of phototransduction regulatory proteins between the inner and outer segments of photoreceptor cells plays a role in the adaptation of these cells to light [13].
• STUDY DESIGN AND METHODS: Light-chain cDNA libraries, constructed from mice immunized with N-type glycophorin A, were inserted into a recombinant pComb3H vector containing the N92 Fd fragment [14].
• Embryonic cholinesterase activity during morphogenesis of the mouse genital tract. Light- and electron-microscopic observations [15].
• The Light mutation (Blt) is a dominant allele of the b-locus on mouse chromosome 4 which causes progressive dilution of coat colour [16].

Anatomical context of Tnfsf14

• CONCLUSIONS: Light exposure induced retinal microglia migration into the subretinal space in albino mice [17].
• RESULTS: Light microscopy demonstrated that Dpt(-/-) corneas in 2-month-old mice showed a 24% reduction in average stromal thickness compared with wild type (P < 0.001) [18].
• Experimental induction of hepatocellular hyalin (Mallory bodies) in mice by griseofulvin treatment. 1. Light microscopic observation [19].
• Incorporation of L-(3H)-fucose into glycoproteins of the adrenal gland of mice. Light microscope radioautographic study on semi-thin sections [20].
• This suggests that strial melanocytes are affected by the Light allele and that the continued presence of melanocytes is necessary for strial function [16].

Associations of Tnfsf14 with chemical compounds

• The Light Peak of the Electroretinogram Is Dependent on Voltage-gated Calcium Channels and Antagonized by Bestrophin (Best-1) [21].
• In control animals, pain-related behavioral reactions (licking and flinching) were higher in the evening (Dark) than in the morning (Light), both during the first (0-10 min) and the second (11-55 min) phase of the response to s.c. formalin [22].
• In animals pre-treated with luzindole, no diurnal changes occurred, pain reactions in the Dark being similar to those of the Light Control group [22].
• Neuropathology of trimethyltin intoxication. I. Light microscopy study [23].
• MATERIALS AND METHODS: Light microscopy observations were performed on liver, renal and heart samples obtained from female Wistar rats treated twice a week for 10 weeks with 1 mg/kg cisplatin (cumulative dose: 20 mg/kg), with or without 100 mg/kg procainamide hydrochloride (cumulative dose: 2 g) [24].

Other interactions of Tnfsf14

• 2. Light microscopic immunocytochemistry revealed that granule cells of the olfactory bulb express only the beta3 as the beta subunit variant, whereas cerebellar stellate and basket cells express only the beta2 as the beta subunit [25].
• RESULTS: Light microscopical examination revealed an overall reduction of DPP IV activity and an altered distribution pattern in glomeruli as early as 4 weeks after induction of graft-versus-host disease [26].
• The central-peripheral transition zone of cervical spinal nerve roots in Jimpy mutant and normal mice. Light- and electron-microscopic study [27].
• Immunohistochemical detection of Fc receptor. I. Light microscopic demonstration of Fc receptor by using soluble immune complexes of peroxidase-antiperoxidase immunoglobulin G [28].
• Fibronectin: its relationship to basement membranes. I. Light microscopic studies [29].

Analytical, diagnostic and therapeutic context of Tnfsf14

• Atrioventricular valves of the mouse: II. Light and transmission electron microscopy [30].
• MATERIALS AND METHODS: Light and electron microscopic methods and cell separation techniques were applied [31].
• Experimental tumors with features of malignant fibrous histiocytomas. Light microscopic and electron microscopic investigations on tumors produced by cell transplantation of an established fibrosarcoma cell line [32].

References