The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CCR1  -  chemokine (C-C motif) receptor 1

Macaca mulatta

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CCR1


High impact information on CCR1

  • The envelope glycoproteins of recombinant SHIVs that efficiently caused loss of CD4(+) T lymphocytes exhibited increased chemokine receptor binding and membrane-fusing capacity compared with those of less pathogenic viruses [6].
  • The beta-chemokine receptor C-C chemokine receptor 3 (CCR3) provides a mechanism for the selective recruitment of eosinophils into tissue and thus has recently become an attractive biological target for therapeutic intervention [7].
  • The C-C chemokine receptor CCR5 serves an important function in chemotaxis of lymphocytes, monocytes, and dendritic cells [3].
  • In addition, although intestinal lymphocytes are susceptible to infection with either X4-HIV particles or particles that use the chemokine receptor CCR5 for viral entry (R5-HIV) during ex vivo culture [5], only systemic inoculation of R5-chimeric simian-HIV (S-HIV) results in a rapid loss of CD4(+) intestinal lymphocytes in macaques [6] [8].
  • Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS [9].

Biological context of CCR1

  • Furthermore, aminoxypentane-RANTES abolishes virus replication, suggesting that these SIV strains utilize the chemokine receptor CCR5 for entry into astrocytes [10].

Anatomical context of CCR1

  • Similar to primary HIV-1 isolates, a well-characterized molecular clone, SIVmac239, which replicates poorly but efficiently enters into rhesus alveolar macrophages and an envelope variant, SIVmac239/316Env, with an approximately 1,000-fold-higher replicative capacity in macrophages used the beta-chemokine receptor CCR5 for efficient entry [11].
  • Expression of chemokine receptor CCR7 and its ligands correlated with recirculation of T lymphocytes through the periphery and homing to paracortical regions of lymph node, where cells remained largely excluded from B-cell follicles [12].
  • We previously demonstrated that macaque trophoblasts express the chemokine receptor CCR5 and that this receptor mediates trophoblast migration toward RANTES (regulated upon activation normal T-cell expressed and secreted) [13].

Associations of CCR1 with chemical compounds

  • Previous studies established an association between the red cell chemokine receptor and Fy6 of the Duffy glycoprotein [14].

Analytical, diagnostic and therapeutic context of CCR1

  • To examine the pathogenesis of this exanthem, biopsies obtained throughout the course of clinically evident rash were examined for the presence of virus by in situ hybridization and immunohistochemistry, and the cellular infiltrate was characterized with respect to cellular immunophenotype and chemokine receptor expression [15].
  • Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human [16].


  1. RANTES, IFN-gamma, CCR1, and CCR5 mRNA expression in peripheral blood, lymph node, and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus infection of macaques. Chéret, A., Le Grand, R., Caufour, P., Neildez, O., Matheux, F., Théodoro, F., Vaslin, B., Dormont, D. Virology (1999) [Pubmed]
  2. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. Farzan, M., Choe, H., Martin, K., Marcon, L., Hofmann, W., Karlsson, G., Sun, Y., Barrett, P., Marchand, N., Sullivan, N., Gerard, N., Gerard, C., Sodroski, J. J. Exp. Med. (1997) [Pubmed]
  3. Immunogenicity of the extracellular domains of C-C chemokine receptor 5 and the in vitro effects on simian immunodeficiency virus or HIV infectivity. Lehner, T., Doyle, C., Wang, Y., Babaahmady, K., Whittall, T., Tao, L., Bergmeier, L., Kelly, C. J. Immunol. (2001) [Pubmed]
  4. The cytomegalovirus-encoded chemokine receptor US28 can enhance cell-cell fusion mediated by different viral proteins. Pleskoff, O., Tréboute, C., Alizon, M. J. Virol. (1998) [Pubmed]
  5. Morphine promotes simian acquired immunodeficiency syndrome virus replication in monkey peripheral mononuclear cells: induction of CC chemokine receptor 5 expression for virus entry. Suzuki, S., Chuang, A.J., Chuang, L.F., Doi, R.H., Chuang, R.Y. J. Infect. Dis. (2002) [Pubmed]
  6. The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques. Karlsson, G.B., Halloran, M., Schenten, D., Lee, J., Racz, P., Tenner-Racz, K., Manola, J., Gelman, R., Etemad-Moghadam, B., Desjardins, E., Wyatt, R., Gerard, N.P., Marcon, L., Margolin, D., Fanton, J., Axthelm, M.K., Letvin, N.L., Sodroski, J. J. Exp. Med. (1998) [Pubmed]
  7. Functional expression and characterization of macaque C-C chemokine receptor 3 (CCR3) and generation of potent antagonistic anti-macaque CCR3 monoclonal antibodies. Zhang, L., Soares, M.P., Guan, Y., Matheravidathu, S., Wnek, R., Johnson, K.E., Meisher, A., Iliff, S.A., Mudgett, J.S., Springer, M.S., Daugherty, B.L. J. Biol. Chem. (2002) [Pubmed]
  8. Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation. Agace, W.W., Amara, A., Roberts, A.I., Pablos, J.L., Thelen, S., Uguccioni, M., Li, X.Y., Marsal, J., Arenzana-Seisdedos, F., Delaunay, T., Ebert, E.C., Moser, B., Parker, C.M. Curr. Biol. (2000) [Pubmed]
  9. Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. Klein, R.S., Williams, K.C., Alvarez-Hernandez, X., Westmoreland, S., Force, T., Lackner, A.A., Luster, A.D. J. Immunol. (1999) [Pubmed]
  10. Expression of simian immunodeficiency virus (SIV) nef in astrocytes during acute and terminal infection and requirement of nef for optimal replication of neurovirulent SIV in vitro. Overholser, E.D., Coleman, G.D., Bennett, J.L., Casaday, R.J., Zink, M.C., Barber, S.A., Clements, J.E. J. Virol. (2003) [Pubmed]
  11. Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry. Kirchhoff, F., Pöhlmann, S., Hamacher, M., Means, R.E., Kraus, T., Uberla, K., Di Marzio, P. J. Virol. (1997) [Pubmed]
  12. Chemokine networks and in vivo T-lymphocyte trafficking in nonhuman primates. Clay, C.C., Rodrigues, D.S., Brignolo, L.L., Spinner, A., Tarara, R.P., Plopper, C.G., Leutenegger, C.M., Esser, U. J. Immunol. Methods (2004) [Pubmed]
  13. Macaque trophoblast migration toward RANTES is inhibited by cigarette smoke-conditioned medium. Thirkill, T.L., Vedagiri, H., Douglas, G.C. Toxicol. Sci. (2006) [Pubmed]
  14. The red cell chemokine receptor is distinct from the Fy6 epitope. Hausman, E., Dzik, W., Blanchard, D. Transfusion (1996) [Pubmed]
  15. Characterization of the cutaneous exanthem in macaques infected with a Nef gene variant of SIVmac239. Sasseville, V.G., Rottman, J.B., Du, Z., Veazey, R., Knight, H.L., Caunt, D., Desrosiers, R.C., Lackner, A.A. J. Invest. Dermatol. (1998) [Pubmed]
  16. Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Napier, C., Sale, H., Mosley, M., Rickett, G., Dorr, P., Mansfield, R., Holbrook, M. Biochem. Pharmacol. (2005) [Pubmed]
WikiGenes - Universities